Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses

Secretory-immunoglobulin A (S-IgA) plays an important role in immunological defense in the intestine. It has been known for a long time that microbial stimulation is required for the development and maintenance of intestinal IgA production. Recent advances in genomic technology have made it possible to detect uncultivable commensal bacteria in the intestine and identify key bacteria in the regulation of innate and acquired mucosal immune responses. In this review, we focus on the immunological function of Peyer’s patches (PPs), a major gut-associated lymphoid tissue, in the induction of intestinal IgA responses and the unique immunological interaction of PPs with commensal bacteria, especially Alcaligenes, a unique indigenous bacteria habituating inside PPs.

• Publication year

  2012

• Venue

  Front. Immun.

• Publication date

  2012-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fimmu.2012.00065PMID 22566946PMCID 3342267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis.

  2010influential reference
• Intestinal bacteria and the regulation of immune cell homeostasis.

  2010cited by this paper
• Intestinal dendritic cells.

  2010cited by this paper
• The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.

  2010cited by this paper
• Host-bacterial symbiosis in health and disease.

  2010cited by this paper
• Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches

  2009cited by this paper
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• Antibody Repertoire Development in Fetal And Neonatal Piglets. IV. Switch Recombination, Primarily in Fetal Thymus, Occurs Independent of Environmental Antigen and Is Only Weakly Associated with Repertoire Diversification1

  2001influential reference
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