Increased Dairy Products Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes.

SCOPE Metabolomics is increasingly used to identify biomarkers of dietary intake or chronic diseases, such as type 2 diabetes. Yet, metabolite signatures following dairy intake in hyperinsulinemic subjects have not been identified. The objective was to evaluate the effects of a high dairy diet (HD) for 6 weeks (≥4 servings/day), compared with an adequate dairy diet (AD) (≤2 servings/day), on serum metabolite profiles in hyperinsulinemic adults. METHODS AND RESULTS In this crossover trial, subjects were randomized to HD or AD for 6 weeks. Serum metabolites were assessed using GC/MS. Twenty-six subjects completed the study (age: 55 ± 14 years, BMI: 31 ± 3 kg/m2 (mean±SD)). Results showed that levels of pentadecanoic acid (p = 0.04), tyrosine (p = 0.009) and lathosterol (p = 0.03) were increased in HD, while 1,5-anhydrosorbitol (p = 0.02), myo-inositol (p = 0.04), 3-aminoisobutyric acid (p = 0.002) and beta-sitosterol (p = 0.01) were decreased. Sorbitol levels were increased after AD (p = 0.03), while hexanoic acid, lauric acid, L-kynurenine, methionine and benzoic acid levels were reduced (p<0.05). Histidine, caprylic acid, nonanoic acid, decanoic acid, lauric acid, heptadecanoic acid and benzoic acid levels were increased in HD compared to AD, while changes in malic acid were increased in AD compared to HD (p<0.05). CONCLUSION Higher dairy products intake modifies metabolite profiles in hyperinsulinemic subjects. This article is protected by copyright. All rights reserved.

• Publication year

  2019

• Venue

  Molecular Nutrition & Food Research

• Publication date

  2019-10-01

• Fields of study

  Agricultural and Food Sciences, Medicine

• Identifiers
  DOI 10.1002/mnfr.201900126PMID 31368661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increased Dairy Product Intake Modifies Plasma Glucose Concentrations and Glycated Hemoglobin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  2019cited by this paper
• Large-Scale Automatic Feature Selection for Biomarker Discovery in High-Dimensional OMICs Data

  2019cited by this paper
• Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle

  2018cited by this paper
• MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

  2018cited by this paper
• Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome.

  2018cited by this paper
• Missing Value Imputation Approach for Mass Spectrometry-based Metabolomics Data

  2018cited by this paper
• Serum metabolic profiling of type 2 diabetes mellitus in Chinese adults using an untargeted GC/TOFMS.

  2018cited by this paper
• Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

  2018cited by this paper
• Comparative Metabolomics Elucidates Postprandial Metabolic Modifications in Plasma of Obese Individuals with Metabolic Syndrome.

  2018cited by this paper
• Benzoic acid and its derivatives as naturally occurring compounds in foods and as additives: Uses, exposure, and controversy

  2017cited by this paper
• A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes

  2017cited by this paper
• Identification of Urinary Food Intake Biomarkers for Milk, Cheese, and Soy-Based Drink by Untargeted GC-MS and NMR in Healthy Humans.

  2017cited by this paper
• Biomarkers for predicting type 2 diabetes development—Can metabolomics improve on existing biomarkers?

  2017cited by this paper
• Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes

  2016cited by this paper
• Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts

  2016cited by this paper
• Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies.

  2016cited by this paper
• Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis

  2016cited by this paper
• Metabolic Effects of a 24-Week Energy-Restricted Intervention Combined with Low or High Dairy Intake in Overweight Women: An NMR-Based Metabolomics Investigation

  2016cited by this paper
• Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study

  2015cited by this paper
• Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial.

  2015cited by this paper
• Recommended dairy product intake modulates circulating fatty acid profile in healthy adults: a multi-centre cross-over study

  2015cited by this paper
• Intakes of whey protein hydrolysate and whole whey proteins are discriminated by LC–MS metabolomics

  2014cited by this paper
• Dietary sorbitol and mannitol: food content and distinct absorption patterns between healthy individuals and patients with irritable bowel syndrome.

  2014cited by this paper
• Potential role and therapeutic interests of myo-inositol in metabolic diseases.

  2013cited by this paper
• 4. Milk Lipids

  2013cited by this paper
• L-arginine enriched biscuits improve endothelial function and glucose metabolism: a pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome.

  2013cited by this paper
• Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam

  2013cited by this paper
• Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

  2013cited by this paper
• Serum Glycine Is Associated with Regional Body Fat and Insulin Resistance in Functionally-Limited Older Adults

  2013cited by this paper
• Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women

  2012cited by this paper
• Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

  2012cited by this paper
• A GC–MS-based metabonomic investigation of blood serum from irritable bowel syndrome patients undergoing intervention with acidified milk products

  2011cited by this paper
• Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study

  2010cited by this paper
• An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys.

  2007cited by this paper
• The Polyol Pathway as a Mechanism for Diabetic Retinopathy: Attractive, Elusive, and Resilient

  2007cited by this paper
• Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options.

  2005cited by this paper
• Evaluation of the odd fatty acids 15:0 and 17:0 in serum and adipose tissue as markers of intake of milk and dairy fat

  2005cited by this paper
• Circulating 1,5-anhydroglucitol levels in adult patients with diabetes reflect longitudinal changes of glycemia: a U.S. trial of the GlycoMark assay.

  2004cited by this paper
• Validity and reproducibility of an interviewer-administered food frequency questionnaire for healthy French-Canadian men and women

  2004cited by this paper
• Nutrition Journal BioMed Central

  2003cited by this paper
• Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men.

  2001cited by this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cited by this paper
• A new colorimetric method for the estimation of glycosylated hemoglobin.

  1981cited by this paper
• Evaluation and comparison of 10 glucose methods and the reference method recommended in the proposed product class standard (1974).

  1977cited by this paper

• Impact of dairy intake on circulating fatty acids and associations with blood pressure: A randomized crossover trial.

  2025cites this paper
• Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa Roseburia, Faecalibacterium, Flavonifractor, and Verrucomicrobia

  2025cites this paper
• Dairy intake and risk of type 2 diabetes and metabolic syndrome: A narrative review.

  2025cites this paper
• Maternal Dietary Protein Patterns and Neonatal Anthropometrics: A Prospective Study with Insights from NMR Metabolomics in Amniotic Fluid

  2023cites this paper
• Predictive Model for Vitamin C Levels in Hyperinsulinemic Individuals Based on Age, Sex, Waist Circumference, Low-Density Lipoprotein, and Immune-Associated Serum Proteins.

  2023cites this paper
• Dairy Intake Modifies the Level of the Bile Acid Precursor and Its Correlation with Serum Proteins Associated with Cholesterol Clearance in Subjects with Hyperinsulinemia

  2023cites this paper
• Lack of Change in Blood Pressure and Arterial Stiffness after High Dairy Intake in Hyperinsulinemic Subjects: A Cross-Over Randomized Controlled Trial.

  2023cites this paper
• High dairy products intake modifies the correlation between α-tocopherol levels and serum proteins related to lipid metabolism in subjects at risk of type 2 diabetes

  2023cites this paper
• Free fatty acid profiling of Greek yogurt by liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis.

  2022cites this paper
• Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review

  2022cites this paper
• Impact of a food-based dietary fat exchange model for replacing dietary saturated with unsaturated fatty acids in healthy men on plasma phospholipids fatty acid profiles and dietary patterns

  2022cites this paper
• Aberrant branched-chain amino acid catabolism in cardiovascular diseases

  2022cites this paper
• Diabetes remission is modulated by branched chain amino acids according to the diet consumed: from the CORDIOPREV study.

  2021cites this paper
• Odd-chain fatty acids as novel histone deacetylase 6 (HDAC6) inhibitors.

  2021cites this paper
• Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans

  2021cites this paper
• A Metabolomics Workflow for Analyzing Complex Biological Samples Using a Combined Method of Untargeted and Target-List Based Approaches

  2020cites this paper
• Statistical and Machine-Learning Analyses in Nutritional Genomics Studies

  2020cites this paper
• A rapid GC method coupled with quadrupole or time of flight mass spectrometry for metabolomics analysis.

  2020cites this paper