Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women.

In Morocco, post-partum women systematically receive a single high-dose of vitamin A (VA) (200 000 IU) within the first month of giving birth and vegetable oil is fortified to increase the VA intake. The efficacy of this combined approach of supplementation and fortification for increasing maternal VA status during lactation is not known. The purpose of the study is to evaluate the effect of post-partum high dose VA supplementation and provision of VA fortified oil for household consumption on plasma and milk retinol concentrations of lactating Moroccan women during the first 6 mo post-partum. Post-partum women aged 19-40 y received a VA supplement and thereafter were randomly assigned to one of two groups to receive weekly vitamin A Fortified Oil (FO) or Non-Fortified Oil (NFO) for 6 months. Serum retinol concentration was higher in the FO group than in the NFO group at 6 mo post-partum (P<0.0001). Milk retinol per g fat at baseline did not differ by group; by 3 mo post-partum, milk retinol per g fat was higher in the FO group than in the NFO group p=0.02) and remained higher throughout 6 mo (P<0.0001). Combined supplementation and fortification has more sustained impact on milk retinol concentrations than supplementation alone. -Supplementation alone had not a sustained impact on milk VA concentrations. -Fortification approach seems to be more effective for maintaining adequate milk VA concentrations among lactating Moroccan women. -Fortification seems to be a long-term solution for the problem of VA deficiency especially among women in low income communities.

• Publication year

  2020

• Venue

  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

• Publication date

  2020-03-01

• Fields of study

  Agricultural and Food Sciences, Medicine

• Identifiers
  DOI 10.1139/apnm-2019-0116PMID 31365834
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• United Nations Children's Fund—UNICEF

  2021cited by this paper
• Vitamin A supplementation during pregnancy for maternal and newborn outcomes.

  2015cited by this paper
• Retinol and retinyl esters: biochemistry and physiology

  2013cited by this paper
• Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less.

  2011cited by this paper
• Vitamin A supplementation during pregnancy for maternal and newborn outcomes.

  2010cited by this paper
• Vitamin A supplementation for postpartum women.

  2010cited by this paper
• Micronutrient needs of malnourished children

  2008cited by this paper
• Evaluation of retinol levels in human colostrum in two samples collected at an interval of 24 hours.

  2007cited by this paper
• Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi.

  2005cited by this paper
• Vitamin A deficiency disorders: international efforts to control a preventable "pox".

  2004cited by this paper
• Estimating the potential for vitamin A toxicity in women and young children.

  2002cited by this paper
• Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants.

  2002cited by this paper
• Vitamin A Requirements of Infants under Six Months of Age

  2001cited by this paper
• Micronutrient report : current progress and trends in the control of vitamin A, iodine, and iron deficiencies

  2001cited by this paper
• Cost analysis as a vitamin A program design and evaluation tool: a case study of the Philippines.

  2000cited by this paper
• Evaluation of serum retinol, the modified-relative-dose-response ratio, and breast-milk vitamin A as indicators of response to postpartum maternal vitamin A supplementation.

  2000cited by this paper
• Maternal vitamin A or beta-carotene supplementation in lactating bangladeshi women benefits mothers and infants but does not prevent subclinical deficiency.

  1999influential reference
• Impact of a single megadose of vitamin A at delivery on breastmilk of mothers and morbidity of their infants

  1997influential reference
• Breast-Milk Vitamin A as an Indicator of the Vitamin A Status of Women and Infants

  1995influential reference
• Breast-milk vitamin A as an indicator of the vitamin A status of women and infants.

  1995cited by this paper
• Global prevalence of vitamin A deficiency

  1995cited by this paper
• The role of vitamin A in child growth, development and survival.

  1994cited by this paper
• High dose vitamin A supplementation of breast-feeding Indonesian mothers: effects on the vitamin A status of mother and infant.

  1993influential reference
• Potential magnitude of the misclassification of a population's trace element status due to infection: example from a survey of young Peruvian children.

  1993cited by this paper
• Vitamin A-fortified monosodium glutamate and vitamin A status: a controlled field trial.

  1988cited by this paper
• The effect of vitamin A fortification of sugar on iron metabolism in preschool children in Guatemala.

  1982cited by this paper
• The effect of vitamin A fortification of sugar on the serum vitamin A levels of preschool Guatemalan children: a longitudinal evaluation.

  1981cited by this paper
• Simple method for determining the caloric and fat content of human milk.

  1980cited by this paper
• An evaluation of strategies to control vitamin A deficiency in the Philippines.

  1979cited by this paper

• Triangular Relation of Food Processing, Nutrition, and Osteoarthritis: A Solution for the Management and Prevention of Osteoarthritis?

  2024cites this paper
• Benefits and Harms of Edible Vegetable Oils and Fats Fortified with Vitamins A and D as a Public Health Intervention in the General Population: A Systematic Review of Interventions

  2023influential citation
• Vitamin A Nutritional Status of Urban Lactating Chinese Women and Its Associated Factors

  2022cites this paper
• Vitamin A Concentration in Human Milk: A Meta-Analysis

  2022cites this paper
• Vitamin A Requirements in Pregnancy and Lactation

  2020cites this paper
• Role of Vitamin A in Mammary Gland Development and Lactation

  2019cites this paper