Role of c-MYC in tumor-associated macrophages and cancer progression

O. Pello,V. Andrés

Published 2013 in Oncoimmunology

ABSTRACT

Transcription factors of the MYC family regulate several homeostatic cell functions, and their role as proto-oncogenes has been the focus of interest for decades. We have recently demonstrated that c-MYC is expressed by tumor-associated macrophages (TAMs) and regulates their phenotype and pro-tumor activities in vivo.

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