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Hybrid chitosan/amniotic membrane-based hydrogels for articular cartilage tissue engineering application

T. V. Toniato,T. Stocco,Danilo dos Santos Martins,L. Santanna,C. Tim,F. R. Marciano,E. C. Silva-Filho,S. P. Campana-Filho,A. Lobo

Published 2020 in International Journal of Polymeric Materials and Polymeric Biomaterials

ABSTRACT

Abstract A hybrid hydrogel combining collagen and chitosan (Ch) and human amniotic membranes (AM) were produced. To produce hybrid hydrogels, a fixed concentration of chitosan (2%) was used, adding AM as a booster at the concentrations of 2.5, 5.0. and 10.0% (w/w). DSC curves showed the denaturation of collagen. The swelling capacity of hydrogels ranged between 333 ± 19% and 368 ± 28%. The groups Ch-1.0 mg/mL and Ch-2.0 mg/mL had an elastic modulus 27% higher than the other groups. Graphical Abstract

PUBLICATION RECORD

  • Publication year

    2020

  • Venue

    International Journal of Polymeric Materials and Polymeric Biomaterials

  • Publication date

    2020-10-12

  • Fields of study

    Medicine, Materials Science, Chemistry, Engineering

  • Identifiers
    DOI 10.1080/00914037.2019.1636249
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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