D-cycloserine does not facilitate fear extinction by reducing conditioned stimulus processing or promoting conditioned inhibition to contextual cues.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Learning & memory (Cold Spring Harbor, N.Y.)

• Publication date

  2012-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1101/lm.026674.112PMID 22984284
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
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  2006influential reference
• Extinction Training in Conjunction with a Partial Agonist of the Glycine Site on the NMDA Receptor Erases Memory Trace

  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction.

  2005influential reference
• Spontaneous recovery.

  2004cited by this paper
• Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.

  2004cited by this paper
• D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement.

  2004influential reference
• Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications.

  2004cited by this paper
• Identification of Calcineurin as a Key Signal in the Extinction of Fear Memory

  2003cited by this paper
• Effects of D-cycloserine on extinction of conditioned freezing.

  2003influential reference
• Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidol

  2003cited by this paper
• Behavioral and neural analysis of extinction.

  2002cited by this paper
• Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats

  2002cited by this paper
• Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery.

  2002cited by this paper
• Context, ambiguity, and unlearning: sources of relapse after behavioral extinction.

  2002cited by this paper
• Contextual control over conditioned responding in a latent inhibition paradigm.

  2000cited by this paper
• The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

  1996cited by this paper
• Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala

  1992cited by this paper
• Mechanisms underlying spontaneous recovery in autoshaping.

  1990cited by this paper
• The order of presentation of conditioned stimuli during extinction

  1983cited by this paper
• A model for Pavlovian learning: variations in the effectiveness of conditioned but not of unconditioned stimuli.

  1980cited by this paper
• Conditional and unconditional components of post-shock freezing

  1980cited by this paper
• Contextual control of the extinction of conditioned fear

  1979cited by this paper
• Role of conditioned contextual stimuli in reinstatement of extinguished fear.

  1979cited by this paper
• Reinstatement of fear to an extinguished conditioned stimulus.

  1975cited by this paper
• Effect of US habituation following conditioning.

  1973cited by this paper
• A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement

  1972cited by this paper
• Pavlovian conditioned inhibition

  1969cited by this paper
• Latent inhibition: effects of frequency of nonreinforced preexposure of the CS.

  1965cited by this paper
• Latent inhibition: the effect of nonreinforced pre-exposure to the conditional stimulus.

  1959cited by this paper
• fficacy of D-Cycloserine for Enhancing Response to ognitive-Behavior Therapy for Panic Disorder

  year unknowncited by this paper

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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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