Characterisation and identification of the human N+-glucuronide metabolite of cediranib.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Pharmaceutical and Biomedical Analysis

• Publication date

  2010-11-02

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jpba.2010.03.023PMID 20409669
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology

  2010cited by this paper
• A convenient new synthesis of quaternary ammonium glucuronides of drug molecules

  2010cited by this paper
• Phase I Study of Cediranib in Combination with Oxaliplatin and Infusional 5-Fluorouracil in Patients with Advanced Colorectal Cancer

  2009cited by this paper
• Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors.

  2007cited by this paper
• AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

  2007cited by this paper
• AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.

  2005cited by this paper
• Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine.

  2001cited by this paper
• Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteins.

  1998cited by this paper
• N+-glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group.

  1998cited by this paper
• Olanzapine 10-N-glucuronide. A tertiary N-glucuronide unique to humans.

  1998cited by this paper
• Species differences in N-glucuronidation.

  1998cited by this paper
• Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

  1993cited by this paper
• Biotransformation of mianserin in laboratory animals and man.

  1992cited by this paper
• A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs. In vitro and in vivo studies.

  1991cited by this paper
• Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine.

  1990cited by this paper
• Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine.

  1983cited by this paper
• Formation and urinary excretion of cyproheptadine glucuronide in monkeys, chimpanzees, and humans.

  1980cited by this paper
• Metabolism of tripelennamine in man.

  1976cited by this paper

• Flow-cell radionuclide analysis

  2020cites this paper
• 22 Quantification of Glucuronide Metabolites in Biological Matrices by LC-MS / MS Jurij Trontelj

  2017cites this paper
• Pharmacokinetic Interaction of Rifampicin with Oral Versus Intravenous Anticancer Drugs: Challenges, Dilemmas and Paradoxical Effects Due to Multiple Mechanisms

  2016cites this paper
• Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.

  2013cites this paper
• Phase I evaluation of the effects of ketoconazole and rifampicin on cediranib pharmacokinetics in patients with solid tumours

  2013cites this paper
• In vitro pharmacokinetic profile of a benzopyridooxathiazepine derivative using rat microsomes and hepatocytes: identification of phases I and II metabolites.

  2013cites this paper
• Why do metabolites circulate?

  2012cites this paper
• Quantification of Glucuronide Metabolites in Biological Matrices by LC-MS/MS

  2012cites this paper
• Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma.

  2012cites this paper
• Tailoring 1H spin dynamics in small molecules via supercooled water: a promising approach for metabolite identification and validation.

  2012cites this paper
• Flow-Cell Analysis

  2012cites this paper
• Mechanisms and analysis of the CNS distribution of cediranib, a molecularly-targeted anti-angiogenic agent.

  2011cites this paper
• Determination of cediranib in mouse plasma and brain tissue using high-performance liquid chromatography-mass spectrometry.

  2011cites this paper
• In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology

  2010cites this paper