Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Virology

• Publication date

  1993-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.67.11.6903-6908.1993PMID 8411396PMCID PMC238141
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A low thymidine kinase-producing mutant of herpes simplex virus type 1 causes latent trigeminal ganglia infections in mice

  2005cited by this paper
• Unusual regulation of expression of the herpes simplex virus DNA polymerase gene

  1993cited by this paper
• Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons

  1993cited by this paper
• Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.

  1992cited by this paper
• Resistance of herpesviruses to antiviral drugs

  1992cited by this paper
• Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes

  1992cited by this paper
• Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site

  1991cited by this paper
• Suppression of ocular herpes recurrences by a thymidine kinase inhibitor in squirrel monkeys.

  1991cited by this paper
• Design of Inhibitors of Herpes Simplex Virus Thymidine Kinase

  1991cited by this paper
• Regulation of herpes simplex virus true late gene expression: sequences downstream from the US11 TATA box inhibit expression from an unreplicated template

  1991cited by this paper
• Upstream promoter elements of the herpes simplex virus type 1 glycoprotein H gene

  1991cited by this paper
• Role of herpes simplex virus thymidine kinase expression in viral pathogenesis and latency.

  1991cited by this paper
• Analysis of the herpes simplex virus type 1 promoter controlling the expression of UL38, a true late gene involved in capsid assembly

  1991cited by this paper
• The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency.

  1991cited by this paper
• Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants

  1990cited by this paper
• Herpes Simplex Virus Resistant to Acyclovir: A Study in a Tertiary Care Center

  1990cited by this paper
• Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses

  1990influential reference
• Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia

  1990cited by this paper
• In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020. II. Studies in immunocompetent and immunosuppressed owl monkeys (Aotus trivirgatus).

  1990cited by this paper
• Suppression of herpes simplex virus type 1 reactivation from latency by (+-)-9-([(Z)-2-(hydroxymethyl)cyclohexyl]methyl) guanine (L-653,180) in vitro

  1990cited by this paper
• Herpes simplex virus resistant to acyclovir. A study in a tertiary care center.

  1990cited by this paper
• Effect of a thymidine kinase inhibitor (L-653,180) on antiviral treatment of experimental herpes simplex virus infection in mice.

  1990cited by this paper
• Latency-associated transcript but not reactivatable virus is present in sensory ganglion neurons after inoculation of thymidine kinase-negative mutants of herpes simplex virus type 1

  1989cited by this paper
• A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture

  1989cited by this paper
• Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?

  1989cited by this paper
• Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency

  1989cited by this paper
• Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus

  1989influential reference
• Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

  1989influential reference
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  1989influential reference
• Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.

  1989cited by this paper
• New Potent and Selective Inhibitors of Herpes Simplex Virus Tbyhidine Kinase

  1989cited by this paper
• Beta-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse.

  1988cited by this paper
• Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1.

  1988cited by this paper
• In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020: construction and evaluation in rodents.

  1988cited by this paper
• Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus after in vivo complementation

  1987cited by this paper
• An inquiry into the mechanisms of herpes simplex virus latency.

  1987cited by this paper
• Transcriptional control signals of a herpes simplex virus type 1 late (gamma 2) gene lie within bases -34 to +124 relative to the 5' terminus of the mRNA

  1986cited by this paper
• The control of herpes simplex virus type-1 late gene transcription: a 'TATA-box'/cap site region is sufficient for fully efficient regulated activity.

  1986cited by this paper
• Thymidine kinase (TK) activity in herpes simplex virus type 1 recombinants that carry insertions affecting regulation of the TK gene.

  1986cited by this paper
• A genetic approach to promoter recognition during trans induction of viral gene expression.

  1986cited by this paper
• Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

  1985cited by this paper
• Establishment of latency in mice by herpes simplex virus 1 recombinants that carry insertions affecting regulation of the thymidine kinase gene

  1985cited by this paper
• Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2

  1984cited by this paper
• In vitro and in vivo transcription initiation sites on the TK-encoding BamHI Q fragment of HSV-1 DNA.

  1984cited by this paper
• Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity

  1981cited by this paper
• Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation.

  1981cited by this paper
• Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

  1981cited by this paper
• Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.

  1981cited by this paper
• The association of herpes simplex virus with squamous carcinoma of the cervix, and studies of the virus thymidine kinase gene

  1980cited by this paper
• Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.

  1979influential reference
• Selective assay for herpes simplex viruses expressing thymidine kinase

  1979cited by this paper
• Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2

  1978cited by this paper

• Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication.

  2021cites this paper
• Transcriptional Regulation of Latency-Associated Transcripts (LATs) of Herpes Simplex Viruses

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• “Non-Essential” Proteins of HSV-1 with Essential Roles In Vivo: A Comprehensive Review

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• [Acyclovir-resistant perineal HSV infection revealing chronic lymphoid leukaemia].

  2017cites this paper
• Aciclovir resistance phenotype of clinical isolates proven by targeted mutagenesis of recombinant herpes simplex and varicella zoster viruses

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• Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System

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  2011cites this paper
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  2003cites this paper
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• Tetracycline-Regulated Gene Expression in Replication-Incompetent Herpes Simplex Virus Vectors

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• Lawrence Corey Immunobiology and Vaccine Research Recent Progress in Herpes Simplex Virus

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• Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir

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  2000cites this paper
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  2000cites this paper
• Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.

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• Replication of Herpes Simplex Virus Type 1 within Trigeminal Ganglia Is Required for High Frequency but Not High Viral Genome Copy Number Latency

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  1996cites this paper
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  1996influential citation
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  1996cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
• Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons

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