Current promising treatment strategy for glioblastoma multiform: A review

Glioblastoma multiform (GBM) is a heterogeneous group of primary neoplasm resistant to conventional therapies. Due to their infiltrative nature it not fully isolated by aggressive surgery, radiation and chemotherapy showing poor prognosis in glioma patients. Unfortunately, diagnosed patients die within 1.5-2 year treatment schedule. Currently temozolomide (TMZ) is the first choice for the prognosis of GBM patients. TMZ metabolites methyl triazen imidazol carboxamide form complex with alkyl guanine alkyl transferase (O6 MGMT- DNA repair protein) induced DNA damage following resistance properties of TMZ and inhibit the overall survival of the patients. Last few decades different TMZ conjugated strategy is developed to overcome the resistance and enhance the chemotherapy efficacy. The main aim of this review is to introduce the new promising pharmaceutical candidates that significantly influence the therapeutic response of the TMZ in context of targeted therapy of glioblastoma patients. It is hoped that this proposed strategy are highly effective to overcome the current resistance limitations of TMZ in GBM patients and enhance the survival rate of the patients.

• Publication year

  2019

• Venue

  Oncology Reviews

• Publication date

  2019-07-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.4081/oncol.2019.417PMID 31410248PMCID 6661528
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line.

  2019cited by this paper
• Proof of Concept in a Case Study of Glioblastoma Multiforme Successfully Treated with IV Quercetin in Combination with Leading Edge Gamma Knife and Standard Treatments

  2018cited by this paper
• Function of neuronal nitric oxide synthase enzyme in temozolomide-induced damage of astrocytic tumor cells.

  2018cited by this paper
• Prognostic and clinicopathological significance of long noncoding RNA HOXA11-AS expression in human solid tumors: a meta-analysis

  2018cited by this paper
• Recycling drug screen repurposes hydroxyurea as a sensitizer of glioblastomas to temozolomide targeting de novo DNA synthesis, irrespective of molecular subtype

  2018cited by this paper
• Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells

  2018cited by this paper
• Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis

  2018cited by this paper
• Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway

  2017cited by this paper
• Tumor response of temozolomide in combination with morphine in a xenograft model of human glioblastoma

  2017cited by this paper
• Message from the Editor-in-Chief.

  2017cited by this paper
• Tumor-inhibition effect of levetiracetam in combination with temozolomide in glioblastoma cells

  2017cited by this paper
• Withaferin A promotes proliferation and migration of brain endothelial cells

  2016cited by this paper
• Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

  2016cited by this paper
• Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy

  2016cited by this paper
• Nanostructured lipid carriers based temozolomide and gene co-encapsulated nanomedicine for gliomatosis cerebri combination therapy

  2016cited by this paper
• Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide.

  2016cited by this paper
• Brain Targeting of Temozolomide via the Intranasal Route Using Lipid-Based Nanoparticles: Brain Pharmacokinetic and Scintigraphic Analyses.

  2016cited by this paper
• Combination Therapy for Gliomas Using Temozolomide and Interferon-Beta Secreting Human Bone Marrow Derived Mesenchymal Stem Cells

  2015cited by this paper
• Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.

  2015cited by this paper
• Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted anti-tumor drug delivery system with sequential release functions

  2015cited by this paper
• Analysis of the ORFK1 hypervariable regions reveal distinct HHV-8 clustering in Kaposi’s sarcoma and non-Kaposi’s cases

  2015cited by this paper
• The effect of valproic acid in combination with irradiation and temozolomide on primary human glioblastoma cells

  2015cited by this paper
• Dihydroartemisinin increases temozolomide efficacy in glioma cells by inducing autophagy.

  2015cited by this paper
• Exploring New Strategies to Overcome Resistance in Glioblastoma Multiforme: A Dissertation

  2015influential reference
• Temozolomide nanoparticles for targeted glioblastoma therapy.

  2015cited by this paper
• Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide)

  2014cited by this paper
• Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation

  2014cited by this paper
• Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.

  2014cited by this paper
• An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells

  2014cited by this paper
• Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells

  2013cited by this paper
• Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization

  2013cited by this paper
• Poly lactic acid (PLA) nanoparticles sustain the cytotoxic action of temozolomide in C6 Glioma cells

  2013cited by this paper
• Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles

  2013cited by this paper
• Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS‐dependent AMPK‐TSC‐mTOR Signaling Pathway

  2012cited by this paper
• Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy.

  2012cited by this paper
• The strategy for enhancing temozolomide against malignant glioma

  2012cited by this paper
• The Effect of Temozolomide/Poly(lactide-co-glycolide) (PLGA)/Nano-Hydroxyapatite Microspheres on Glioma U87 Cells Behavior

  2012cited by this paper
• Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.

  2011cited by this paper
• Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.

  2009cited by this paper
• Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.

  2009cited by this paper
• Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocytoma

  2007cited by this paper
• Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse

  2007cited by this paper
• Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents.

  2006cited by this paper
• Recurrent glioblastoma multiforme: advances in treatment and promising drug candidates

  2006cited by this paper
• Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells

  2003cited by this paper

• Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting

  2025cites this paper
• Advanced nanomicelles for targeted glioblastoma multiforme therapy.

  2025cites this paper
• Boric Acid Induces Oxidative Damage and Apoptosis Through SEMA3A/PLXNA1/NRP1 Signalling Pathway in U251 Glioblastoma Cell

  2025cites this paper
• Multi-functional F127-grafted vitamin E succinate-modified liposomes for enhancing glioma therapy.

  2025cites this paper
• Adoptive macrophages suppress glioblastoma growth by reversing immunosuppressive microenvironment through programmed phenotype repolarization.

  2025cites this paper
• Polymer-Drug Conjugates Codeliver a Temozolomide Intermediate and Nitric Oxide for Enhanced Chemotherapy against Glioblastoma Multiforme.

  2024cites this paper
• Transforming Agents: The Power of Structural Modifications in Glioblastoma Multiforme Therapy.

  2024cites this paper
• Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

  2024cites this paper
• Identification of a novel glioblastoma multiforme molecular subtype with poor prognosis and high immune infiltration based on oxidative stress-related genes

  2024cites this paper
• Characterization of prevalent tyrosine kinase inhibitors and their challenges in glioblastoma treatment

  2024cites this paper
• Unlocking Glioblastoma Vulnerabilities with CRISPR-Based Genetic Screening

  2024influential citation
• Photodynamic and sonodynamic therapy synergy: mechanistic insights and cellular responses against glioblastoma multiforme

  2024cites this paper
• Membranome Similarity between Glioblastoma Multiforme Cell Lines and Primary Tumors

  2023cites this paper
• Terpenes-Modified Lipid Nanosystems for Temozolomide, Improving Cytotoxicity against Glioblastoma Human Cancer Cells In Vitro

  2023cites this paper
• Longitudinal 3-D Visualization of Microvascular Disruption and Perfusion Changes in Mice During the Evolution of Glioblastoma Using Super-Resolution Ultrasound

  2023influential citation
• The Antitumor Effect of the DNA Polymerase Alpha Inhibitor ST1926 in Glioblastoma: A Proteomics Approach

  2023cites this paper
• Y-box protein-1 modulates circSPECC1 to promote glioma tumorigenesis via miR-615-5p/HIP1/AKT axis

  2023cites this paper
• Interactions between microglia and glioma in tumor microenvironment

  2023cites this paper
• RRAGB-mediated suppression of PI3K/AKT exerts anti-cancer role in glioblastoma.

  2023cites this paper
• Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression

  2023cites this paper
• Exosomes released from U87 glioma cells treated with curcumin and/or temozolomide produce apoptosis in naive U87 cells.

  2023cites this paper
• Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma.

  2023cites this paper
• Evaluation of the Expression of miRNAs, LncRNAs, and their Target Gene, Caspase 3 in Glioblastoma Multiform: A Case–Control Study

  2023cites this paper
• Bevacizumab in real-life patients with recurrent glioblastoma: benefit or futility?

  2023cites this paper
• Hydroxychavicol as a potential anticancer agent (Review)

  2022cites this paper
• The Aurora Kinase Inhibitor TAK901 Inhibits Glioblastoma Growth by Blocking SREBP1-Mediated Lipid Metabolism

  2022cites this paper
• The synergistic anti-Warburg efficacy of temozolomide, metformin and epigallocatechin gallate in glioblastoma

  2022cites this paper
• Boswellic acids as promising agents for the management of brain diseases.

  2022cites this paper
• Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond O‑6‑Methylguanine‑DNA Methyltransferase.

  2022cites this paper
• A Boronated Derivative of Temozolomide Showing Enhanced Efficacy in Boron Neutron Capture Therapy of Glioblastoma

  2022cites this paper
• Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma

  2022cites this paper
• Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models

  2022cites this paper
• Theranostic Potential of Adaptive Cold Atmospheric Plasma with Temozolomide to Checkmate Glioblastoma: An In Vitro Study

  2022cites this paper
• Selectively expressed RNA molecules: a new dimension in functionalized cell targeting

  2022cites this paper
• The Signaling Pathways Controlling the Efficacy of Glioblastoma Therapy

  2022cites this paper
• The low affinity A2B adenosine receptor enhances migratory and invasive capacity in vitro and angiogenesis in vivo of glioblastoma stem-like cells

  2022cites this paper
• Specificity, Safety, Efficacy of EGFRvIII-Retargeted Oncolytic HSV for Xenotransplanted Human Glioblastoma

  2021cites this paper
• Intermittent radiotherapy as alternative treatment for recurrent high grade glioma: a modeling study based on longitudinal tumor measurements

  2021cites this paper
• Reuse of Molecules for Glioblastoma Therapy

  2021cites this paper
• Evaluation of the cytotoxic and immunogenic potential of temozolamide, panobinostat, and Lophophora williamsii extract against C6 glioma cells

  2021cites this paper
• FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK‐3β/β‐catenin pathway

  2021cites this paper
• Perspective of mesenchymal transformation in glioblastoma

  2021cites this paper
• Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway

  2021cites this paper
• Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells

  2021cites this paper
• State of Radiomics in Glioblastoma.

  2021cites this paper
• A Heterotypic Tridimensional Model to Study the Interaction of Macrophages and Glioblastoma In Vitro

  2021cites this paper
• Mesenchymal stem cellsA@ in glioblastoma therapy and progression: How one cell does it all.

  2021cites this paper
• Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives

  2021cites this paper
• SD‐36 promotes growth inhibition and induces apoptosis via suppression of Mcl‐1 in glioma

  2021cites this paper
• Potential of naso-brain drug delivery in glioblastoma therapy

  2021cites this paper
• Molecular mechanisms in temozolomide-resistant glioblastoma

  2021cites this paper
• Old Stars and New Players in the Brain Tumor Microenvironment

  2021cites this paper
• Time-resolved fluorescence imaging technique for rat brain tumors analysis

  2021cites this paper
• An overview of current therapeutic strategies for glioblastoma and the role of CD73 as an alternative curative approach

  2021cites this paper
• The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells

  2021cites this paper
• Strategies for Developing Complex Multi-Component In Vitro Tumor Models: Highlights in Glioblastoma.

  2021cites this paper
• Recent Advancements in Nanodiamond Mediated Brain Targeted Drug Delivery and Bioimaging of Brain Ailments: A Holistic Review.

  2021cites this paper
• Sitokalasin B Tedavisi, Nrf2 Sinyal Yoluyla U87 Glioblastoma Hücrelerinde Anti-Proliferatif Etkiler Gösterdi

  2021cites this paper
• CMAR_A_258584 8341..8354

  2020cites this paper
• SETDB1 Promotes the Growth of Glioma via CSF-1-dependent Macrophage Recruitment by Activating the AKT/mTOR Signaling Pathway

  2020cites this paper
• Lestaurtinib potentiates TRAIL‐induced apoptosis in glioma via CHOP‐dependent DR5 induction

  2020cites this paper
• Long Non-coding RNA EPIC1 Promotes Cell Proliferation and Motility and Drug Resistance in Glioma

  2020cites this paper
• MicroRNA‐155‐3p promotes glioma progression and temozolomide resistance by targeting Six1

  2020cites this paper
• miR‐152‐5p suppresses glioma progression and tumorigenesis and potentiates temozolomide sensitivity by targeting FBXL7

  2020cites this paper
• Glioblastoma Stem Cells as a Therapeutic Target

  2020cites this paper
• Ultrasound-activated nano-TiO2 loaded with temozolomide paves the way for resection of chemoresistant glioblastoma multiforme

  2020cites this paper
• Study of possibility of cell recognition in brain tumors

  2020cites this paper
• Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

  2020cites this paper
• The Anti-Cancer Effect of Linusorb B3 from Flaxseed Oil through the Promotion of Apoptosis, Inhibition of Actin Polymerization, and Suppression of Src Activity in Glioblastoma Cells

  2020influential citation
• Targeting the brain: various approaches and science involved

  2020cites this paper
• Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

  2020cites this paper
• Sex differences in the antidepressant-like potential of repeated electroconvulsive seizures in adolescent and adult rats: Regulation of the early stages of hippocampal neurogenesis.

  2020cites this paper
• Mechanistic models of signaling pathways deconvolute the glioblastoma single-cell functional landscape

  2020cites this paper
• Temozolomide treatment combined with AZD3463 shows synergistic effect in glioblastoma cells.

  2020cites this paper
• BET degrader inhibits tumor progression and stem-like cell growth via Wnt/β-catenin signaling repression in glioma cells

  2020cites this paper
• Cancer Stem Cells: New Horizons in Cancer Therapies

  2020cites this paper
• SETDB1 promotes glioblastoma growth via CSF-1-dependent macrophage recruitment by activating the AKT/mTOR signaling pathway

  2020cites this paper
• Arctigenin Inhibits Glioblastoma Proliferation through the AKT/mTOR Pathway and Induces Autophagy

  2020cites this paper
• Synergistic Effects of Resveratrol and Temozolomide Against Glioblastoma Cells: Underlying Mechanism and Therapeutic Implications

  2020cites this paper
• A facile and scalable in production non-viral gene engineered mesenchymal stem cells for effective suppression of temozolomide-resistant (TMZR) glioblastoma growth

  2020cites this paper
• Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment

  2020cites this paper
• Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells

  2020cites this paper
• LncRNA NFIA-AS2 promotes glioma progression through modulating the miR-655-3p/ZFX axis

  2020cites this paper
• Matrix Stiffness Modulates Patient-Derived Glioblastoma Cell Fates in Three-Dimensional Hydrogels

  2020cites this paper
• Tissue and Stem Cell Sourced Extracellular Vesicle Communications with Microglia

  2020cites this paper
• Combined Targeting of Glioblastoma Stem-Like Cells by Neutralizing RNA-Bio-Drugs for STAT3

  2020cites this paper
• Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line.

  2019cites this paper
• A tropomyosin-like Meretrix meretrix Linnaeus polypeptide inhibits the proliferation and metastasis of glioma cells via microtubule polymerization and FAK/Akt/MMPs signaling.

  2019cites this paper
• Mechanistic models of signaling pathways deconvolute the functional landscape of glioblastoma at single cell resolution

  2019cites this paper
• Theranostic Nanomedicine for Malignant Gliomas

  2019cites this paper