Improved glutathione production by gene expression in Pichia pastoris

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Bioprocess and biosystems engineering (Print)

• Publication date

  2009-01-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00449-009-0297-xPMID 19153769
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of amino acids addition and feedback control strategies on the high-cell-density cultivation of Saccharomyces cerevisiae for glutathione production

  2007cited by this paper
• Optimization of the medium for glutathione production in Saccharomyces cerevisiae

  2007cited by this paper
• Influence of culture conditions on glutathione production by Saccharomyces cerevisiae

  2007cited by this paper
• Maximizing production of glutathione by amino acid modulation and high-cell-density fed-batch culture of Saccharomyces cerevisiae

  2006cited by this paper
• Optimization of the amino acid composition in glutathione fermentation

  2005cited by this paper
• Optimal fermentation conditions for enhanced glutathione production by Saccharomyces cerevisiae FF-8.

  2004cited by this paper
• Cultivation of Saccharomyces cerevisiae in continuous culture

  2004cited by this paper
• Cultivation of Saccharomyces cerevisiae in continuous culture

  2004cited by this paper
• Effect of amino acids on glutathione production by Saccharomyces cerevisiae

  2004cited by this paper
• Effect of surfactants on extracellular accumulation of glutathione by Saccharomyces cerevisiae

  2003cited by this paper
• Glutathione: a marker and antioxidant for aging.

  2002cited by this paper
• Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells.

  2002cited by this paper
• Oxidant stress induces gamma‐glutamylcysteine synthetase and glutathione synthesis in human bronchial epithelial NCI‐H292 cells

  2002cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Heterologous protein expression in the methylotrophic yeast Pichia pastoris.

  2000cited by this paper
• Glutathione and immune function

  2000cited by this paper
• A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses.

  2000cited by this paper
• Changes in superoxide production rate and in superoxide dismutase and glutathione peroxidase activities in subcellular organelles in mouse liver under exposure to low doses of low-intensity radiation.

  2000cited by this paper
• Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiae.

  1998cited by this paper
• Advanced control of glutathione fermentation process

  1992cited by this paper
• Molecular cloning of the gamma-glutamylcysteine synthetase gene of Saccharomyces cerevisiae.

  1991cited by this paper
• Molecular cloning of the γ‐glutamylcysteine synthetase gene of Saccharomyces cerevisiae

  1991cited by this paper
• High-productivity fermentation process for cultivating industrial microorganisms

  1987cited by this paper
• The glutathione peroxidase reaction: molecular basis of the antioxidant function of selenium in mammals.

  1985cited by this paper
• Glutathione.

  1983cited by this paper
• Cultivation of Saccharomyces cerevisiae in continuous culture. II. Influence of the crabtree effect on the growth characteristics of Saccharomyces cerevisiae grown in a glucose limited chemostat.

  1972cited by this paper
• Tissue sulfhydryl groups.

  1959cited by this paper
• Synthesis of glutathione from gamma-glutamylcysteine.

  1953cited by this paper
• Formation and utilization of gamma-glutamylcysteine in glutathione synthesis.

  1952cited by this paper
• Enzymatic synthesis of glutathione.

  1951cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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• Glutathione Metabolism in Yeasts and Construction of the Advanced Producers of This Tripeptide

  2019cites this paper
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  2018influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016influential citation
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  2015cites this paper
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• Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production.

  2015cites this paper
• [Recent development of Pichia pastoris system: current status and future perspective].

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  2015cites this paper
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  year unknowncites this paper