Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Oncogene

• Publication date

  2007-04-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1210026PMID 17016432
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
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  2006cited by this paper
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  2006cited by this paper
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• Expression pattern of Wnt signaling components in the adult intestine.

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• Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth.

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• Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma.

  2005influential reference
• Migrating cancer stem cells — an integrated concept of malignant tumour progression

  2005influential reference
• Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition

  2004cited by this paper
• Frizzled/WNT signalling: the insidious promoter of tumour growth and progression.

  2004influential reference
• The Wnt Antagonist sFRP1 in Colorectal Tumorigenesis

  2004cited by this paper
• Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation.

  2004cited by this paper
• The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells

  2004cited by this paper
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  2004cited by this paper
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  1999influential reference
• beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer.

  1999influential reference
• Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

  1998cited by this paper
• The legacy of lithium effects on development.

  1998cited by this paper
• c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression.

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  1997influential reference
• Effect of TGF‐β on differentiated organoids of the colon carcinoma cell line LIM 1863

  1995cited by this paper
• Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas.

  1995cited by this paper
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  1992cited by this paper
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  1987influential reference

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