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Quercetin administration post-weaning attenuates high-fructose, high-cholesterol diet-induced hepatic steatosis in growing, female, Sprague Dawley rat pups.

J. Donaldson,M. Ngema,P. Nkomozepi,K. Erlwanger

Published 2019 in The Journal of the Science of Food and Agriculture

ABSTRACT

BACKGROUND Fructose and cholesterol-rich diets are implicated in the upsurge of metabolic syndrome (MetS). Phytochemicals are being explored as alternatives for the prevention and management of MetS. Thirty-six, 21-day old, female, Sprague Dawley rats fed a high-fructose, high-cholesterol diet, post-weaning were used to investigate the prophylactic potential of quercetin. Group 1: standard rat chow (SRC); Group 2: SRC, quercetin (75 mg/kg daily); Group 3: SRC, fenofibrate (100 mg/kg daily); Group 4: high cholesterol diet (HCD) (2 % added dietary cholesterol in SRC), 20 % fructose drinking solution (FS); Group 5: HCD, 20 % FS, quercetin (75 mg/kg daily); Group 6: HCD, 20 % FS, fenofibrate (100 mg/kg daily). Rats were fed ad libitum for eight weeks, euthanased and blood and liver samples collected. RESULTS The HCD and FS significantly increased (p<0.05) absolute and relative liver masses and serum cholesterol. Fasting blood glucose, serum triglycerides, alanine transaminase, creatinine and urea were not significantly different (p>0.05) between groups. The HCD and FS significantly increased liver lipid yield compared to the SRC and that in rats receiving SRC with fenofibrate (p<0.05). Quercetin or fenofibrate together with HCD and FS attenuated the diet-induced increase in liver lipids by approximately 50 %, although not statistically significant. Liver macro- and micro-steatosis scores were significantly increased (p<0.05) in rats receiving HCD and FS. Quercetin or fenofibrate administration together with HCD and FS significantly decreased (p<0.05) liver macro-steatosis scores. CONCLUSION The prophylactic effect of quercetin on fructose and cholesterol diet-induced liver lipid accumulation may be exploited in the fight against NAFLD. This article is protected by copyright. All rights reserved.

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