Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Life Science

• Publication date

  1996-08-16

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0024-3205(96)00408-0PMID 8809215
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid

  2007cited by this paper
• 4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse

  2005cited by this paper
• Pharmacokinetics of isotretinoin during repetitive dosing to patients

  2004cited by this paper
• Identification of 14-hydroxy-4,14-retro-retinol as an in vivo metabolite of vitamin A.

  1996cited by this paper
• Teratogenicity of high vitamin A intake.

  1996cited by this paper
• 9,13-Di-cis-retinoic acid is the major circulating geometric isomer of retinoic acid in the periparturient period.

  1995cited by this paper
• Teratogenicity of high vitamin A intake.

  1995cited by this paper
• Placental transfer and developmental effects of 9-cis retinoic acid in mice.

  1995cited by this paper
• Identification of 9-cis,13-cis-retinoic acid as a major circulating retinoid in plasma.

  1995cited by this paper
• Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate following daily administrations in rats.

  1994cited by this paper
• Identification of 9,13-dicis-retinoic acid as a major plasma metabolite of 9-cis-retinoic acid and limited transfer of 9-cis-retinoic acid and 9,13-dicis-retinoic acid to the mouse and rat embryos.

  1994cited by this paper
• In vivo isomerization of retinoic acids. Rapid isomer exchange and gene expression.

  1994cited by this paper
• The Teratogenic Metabolites of Vitamin A in Women Following Supplements and Liver

  1994cited by this paper
• Single-run analysis of isomers of retinoyl-beta-D-glucuronide and retinoic acid by reversed-phase high-performance liquid chromatography.

  1994cited by this paper
• Maternal toxicokinetics, metabolism, and embryo exposure following a teratogenic dosing regimen with 13-cis-retinoic acid (isotretinoin) in the cynomolgus monkey.

  1994cited by this paper
• Retinoids in Clinical Practice

  1994cited by this paper
• 9-cis-retinoic acid: a direct-acting dysmorphogen.

  1993cited by this paper
• 9-cis-retinoic acid, a potent inducer of digit pattern duplications in the chick wing bud.

  1993cited by this paper
• Retinoids in cancer prevention and therapy.

  1992cited by this paper
• 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.

  1992cited by this paper
• Retinoids are important cofactors in T cell activation

  1992cited by this paper
• Retinoids in Clinical Practice: The Risk-benefit Ratio

  1992cited by this paper
• Retinoids and their receptors in differentiation, embryogenesis, and neoplasia.

  1991cited by this paper
• Recommendations for isotretinoin use in women of childbearing potential.

  1991cited by this paper
• Intracellular signaling by 14-hydroxy-4,14-retro-retinol.

  1991cited by this paper
• Formation of all-trans-retinoic acid and 13-cis-retinoic acid from all-trans-retinyl palmitate in humans

  1991cited by this paper
• Retinoids and their receptors in differentiation, embryogenesis, and neoplasia

  1991cited by this paper
• Physiological occurrence, biosynthesis and metabolism of retinoic acid: evidence for roles of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) in the pathway of retinoic acid homeostasis.

  1991cited by this paper
• Human plasma all-trans-, 13-cis- and 13-cis-4-oxoretinoic acid profiles during subchronic vitamin A supplementation: comparison to retinol and retinyl ester plasma levels.

  1991cited by this paper
• Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma.

  1990cited by this paper
• Retinoic acid induced HL-60 myeloid differentiation: dependence of early and late events on isomeric structure.

  1986cited by this paper
• Retinoic acid embryopathy.

  1985cited by this paper
• Vitamin A and retinoids: from nutrition to pharmacotherapy in dermatology and oncology.

  1983cited by this paper

• Retinoic acid homeostasis and disease.

  2025cites this paper
• Vitamin A5: Evidence, Definitions, Gaps, and Future Directions

  2025cites this paper
• Vitamin A – discovery, metabolism, receptor signaling and effects on bone mass and fracture susceptibility

  2024cites this paper
• Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential

  2024cites this paper
• Retinoid X receptor agonists as selective modulators of the immune system for the treatment of cancer.

  2023cites this paper
• Carotenoid Metabolites, their Tissue and Blood Concentrations in Humans and further Bioactivity via Retinoid Receptor-Mediated Signalling.

  2022cites this paper
• Vitamin A and provitamin A carotenoids

  2020cites this paper
• Measurement of the agonistic activities of monohydroxylated polychlorinated biphenyls at the retinoid X and retinoic acid receptors using recombinant yeast cells.

  2019cites this paper
• Alternative retinoid X receptor (RXR) ligands.

  2019cites this paper
• 9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5

  2018cites this paper
• Opinion on Dietary Reference Values for vitamin

  2018influential citation
• Vitamin A

  2018cites this paper
• Retinoic acid signalling is a candidate regulator of the expression of pituitary‐specific transcription factor Prop1 in the developing rodent pituitary

  2018cites this paper
• One pot synthesis of important retinoid synthon by the catalytic regioselective bi-functionalization of acetylenes, alcohol and carbon monoxide

  2017cites this paper
• The interrelationship between bile acid and vitamin A homeostasis.

  2017cites this paper
• An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!

  2016cites this paper
• SINGLE NUCLEOTIDE POLYMORPHISMS IN VITAMIN A, FOLATE AND CHOLINE RELATED GENES AND INTERACTION WITH MATERNAL VITAMIN INTAKE AND NEUROBLASTOMA

  2016cites this paper
• Vitamin A Metabolism, Storage and Tissue Delivery Mechanisms

  2015cites this paper
• Before life begins

  2015cites this paper
• Scientific Opinion on Dietary Reference Values for vitamin A

  2015influential citation
• The inverse association between serum 25-hydroxyvitamin D and mortality may be modified by vitamin A status and use of vitamin A supplements

  2015cites this paper
• Retinoic acid receptors: from molecular mechanisms to cancer therapy.

  2015cites this paper
• Use of fast HPLC multiple reaction monitoring cubed for endogenous retinoic acid quantification in complex matrices.

  2015cites this paper
• Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers

  2014cites this paper
• The multifaceted nature of retinoid transport and metabolism.

  2014cites this paper
• Alternative activation of dendritic cells

  2013cites this paper
• Vitamin A und Carotinoide

  2013cites this paper
• Retinol and retinyl esters: biochemistry and physiology

  2013cites this paper
• Thematic Review Series: Fat-Soluble Vitamins: Vitamin A Retinol and retinyl esters: biochemistry and physiology

  2013cites this paper
• The role of vitamin A in bile acid synthesis and transport and the relevance for cholestatic liver disease

  2013cites this paper
• Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications

  2012cites this paper
• Serum 25-hydroxyvitamin D, vitamin A, and lung cancer mortality in the US population: a potential nutrient–nutrient interaction

  2012cites this paper
• Cyanobacteria blooms produce teratogenic retinoic acids

  2012cites this paper
• Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.

  2012cites this paper
• Analysis, occurrence, and function of 9-cis-retinoic acid.

  2012cites this paper
• An enzymatic mechanism for generating the precursor of endogenous 13‐cis retinoic acid in the brain

  2011cites this paper
• Vitamin A and beta-carotene metabolism during mammalian embryonic development

  2011cites this paper
• Niveaux de vitamine a (retinol et acide retinoïque) mesurés dans le sang de cordon ombilical et dévéloppement rénal des nouveau-nés

  2010cites this paper
• Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex.

  2010cites this paper
• Quantification of endogenous retinoids.

  2010cites this paper
• The endogenous retinoid metabolite S‐4‐oxo‐9‐cis‐13,14‐dihydro‐retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo

  2009cites this paper
• Application of a Key Events Dose-Response Analysis to Nutrients: A Case Study with Vitamin A (Retinol)

  2009cites this paper
• Retinoic acid synthesis and signaling during early organogenesis.

  2008cites this paper
• Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect

  2008cites this paper
• Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry.

  2008cites this paper
• Development of ultrasensitive chromatographic tools for high-throughput analysis of retinoids in biological samples

  2007cites this paper
• Effects of dietary retinoids and carotenoids on immune development*

  2007cites this paper
• Physiological role of retinyl palmitate in the skin.

  2007cites this paper
• CHARACTERIZATION OF THE LOCUST

  2007cites this paper
• 9-cis beta-carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients.

  2006cites this paper
• Retinoids in clinical use.

  2006cites this paper
• Overview of retinoid metabolism and function.

  2006cites this paper
• Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry.

  2006cites this paper
• Nutrient Metabolism Embryotoxic Doses of Vitamin A to Rabbits Result in Low Plasma but High Embryonic Concentrations of All-£rans-RetinoicAcid: Risk of Vitamin A Exposure in Humans1'2'3

  2006cites this paper
• The acute and chronic toxic effects of vitamin A.

  2006cites this paper
• Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development.

  2005cites this paper
• Exposure to retinoic acids in non-pregnant women following high vitamin A intake with a liver meal.

  2005influential citation
• Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer.

  2004cites this paper
• Retinoid processing in vivo : Characterization and structure-function analysis of retinol dehydrogenases

  2003cites this paper
• Effect of co-administration of retinoids on rat embryo development in vitro.

  2003cites this paper
• Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: a population-based case-control study in Denmark, 1991-1994.

  2003cites this paper
• Vitamin A and infancy. Biochemical, functional, and clinical aspects.

  2003cites this paper
• Chapter 21 – Retinoids in Liver Fibrosis: Induction of Proteolytic Activation of Transforming Growth Factor-β by Retinoic Acid and Its Therapeutic Control by Protease Inhibitors

  2003cites this paper
• Automated solid-phase extraction and liquid chromatographic method for retinoid determination in biological samples.

  2003cites this paper
• Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.

  2003cites this paper
• Estimating the potential for vitamin A toxicity in women and young children.

  2002cites this paper
• Characterization of a new endogenous vitamin A metabolite.

  2002cites this paper
• Retinoids in liver fibrosis and cancer.

  2002cites this paper
• Porcine intestinal metabolism of excess vitamin a differs following vitamin a supplementation and liver consumption.

  2002cites this paper
• Retinoic acid metabolites in plasma are higher after intake of liver paste compared with a vitamin A supplement in women.

  2001cites this paper
• Safety and Toxicity of Vitamin A Supplements in Pregnancy

  2001cites this paper
• The promise of retinoids to fight against cancer

  2001cites this paper
• Vitamin A teratogenicity and risk assessment in the macaque retinoid model.

  2001cites this paper
• Vitamin A and Carotenoid Toxicity

  2001cites this paper
• Retinoids in embryonal development.

  2000cites this paper
• Substrate specificities and 13-cis-retinoic acid inhibition of human, mouse and bovine cis-retinol dehydrogenases.

  2000cites this paper
• Factors affecting blood levels of vitamin A

  2000influential citation
• Teratogenicity, tissue distribution, and metabolism of the retro-retinoids, 14-hydroxy-4,14-retro-retinol and anhydroretinol, in the C57BL/6J mouse.

  2000cites this paper
• Biological effects and metabolism of 9-cis-retinoic acid and its metabolite 9,13-di-cis-retinoic acid in HaCaT keratinocytes in vitro: comparison with all-trans-retinoic acid

  2000cites this paper
• Long-term follow-up of aneurysms developed during extracranial internal carotid artery dissection

  2000cites this paper
• Dietary vitamin A and teratogenic risk: European Teratology Society discussion paper.

  1999cites this paper
• Untersuchungen zum Metabolismus von Vitamin A / Retinoiden im Hinblick auf eine Risikoabschätzung ihrer teratogenen Wirkung beim Menschen

  1999cites this paper
• Human Uterine Leiomyomata Express Higher Levels of Peroxisome Proliferator-activated Receptor γ, Retinoid X Receptor α, and all-trans Retinoic Acid Than Myometrium

  1999cites this paper
• Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo.

  1999cites this paper
• Retinoids and Liver Fibrosis

  1999cites this paper
• Retro-Retinoids: Metabolism and Action

  1999cites this paper
• Retinoid Receptors, Their Ligands, and Teratogenesis: Synergy and Specificity of Effects

  1999cites this paper
• Retinoic acid hydroxylation and teratogenesis in lake sturgeon (Acipenser fulvescens) from the St. Lawrence River and Abitibi region, Quebec

  1999cites this paper
• Model predicting the teratogenic potential of retinyl palmitate, using a combined in vivo/in vitro approach.

  1998cites this paper
• A novel assay for retinoic acid catabolic enzymes shows high expression in the developing hindbrain.

  1998cites this paper
• 9,13-Dicis-retinoic acid as an isomerization product of 9-cis-retinoic acid.

  1997cites this paper
• Embryotoxic doses of vitamin A to rabbits result in low plasma but high embryonic concentrations of all-trans-retinoic acid: risk of vitamin A exposure in humans.

  1996cites this paper
• Long-term follow-up of aneurysms developed during extracranial internal carotid artery dissection

  year unknowncites this paper
• Handbook 2 13-cis-Retinoic acid 1 . Chemical and Physical Characteristics

  year unknowncites this paper