A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Phytochemistry

• Publication date

  2017-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.phytochem.2017.02.001PMID 28190678
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation.

  2016cited by this paper
• Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats.

  2016cited by this paper
• Clerodane diterpenes: sources, structures, and biological activities.

  2016cited by this paper
• Cytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum.

  2016cited by this paper
• Salvinorin A content in legal high products of Salvia divinorum sold in Mexico.

  2015cited by this paper
• EXTRACTION AND ANALYTICAL STUDY OF SALVINORIN A FROM LEAVES OF SALVIA DIVINORUM

  2015cited by this paper
• Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys

  2014cited by this paper
• Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.

  2014cited by this paper
• Analytical investigation of legal high products containing Salvia divinorum traded in smartshops and internet.

  2014cited by this paper
• From local to global-fifty years of research on Salvia divinorum.

  2014cited by this paper
• A validated procedure for detection and quantitation of salvinorin a in pericardial fluid, vitreous humor, whole blood and plasma using solid phase extraction and gas chromatography-mass spectrometry.

  2013cited by this paper
• Salvia divinorum: from Mazatec medicinal and hallucinogenic plant to emerging recreational drug

  2013cited by this paper
• Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors*

  2012cited by this paper
• A Report of Nausea and Vomiting with Discontinuation of Chronic Use of Salvia divinorum

  2012cited by this paper
• Use of Salvia divinorum in a Nationally Representative Sample

  2012cited by this paper
• Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via extracellular signal-regulated kinase/mitogen-activated protein kinase in piglets.

  2012cited by this paper
• Neuropharmacology of the Naturally Occurring κ-Opioid Hallucinogen Salvinorin A

  2011cited by this paper
• Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum.

  2011cited by this paper
• Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers

  2011cited by this paper
• Pharmacological activity of Salvinorin A, the major component of Salvia divinorum

  2011cited by this paper
• Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats.

  2010cited by this paper
• Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens

  2010cited by this paper
• Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats

  2010cited by this paper
• Natural Products from the Hallucinogenic Sage

  2010cited by this paper
• Selective natural kappa opioid and cannabinoid receptor agonists with a potential role in the treatment of gastrointestinal dysfunction.

  2009cited by this paper
• Salvinorins J from Salvia divinorum: mutarotation in the neoclerodane system.

  2009cited by this paper
• Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats.

  2009cited by this paper
• Potential anxiolytic‐ and antidepressant‐like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents

  2009cited by this paper
• Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen.

  2009cited by this paper
• nvolvement of-Opioid and Endocannabinoid System n Salvinorin A-Induced Reward

  2008cited by this paper
• Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward.

  2008cited by this paper
• Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans

  2008cited by this paper
• Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan.

  2008cited by this paper
• Salvia divinorum and Salvinorin A: An Update on Pharmacology and Analytical Methodology

  2007cited by this paper
• The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation‐induced hypermotility in mice

  2007cited by this paper
• Salvinorin A: from natural product to human therapeutics.

  2006cited by this paper
• The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea‐pig ileum

  2006cited by this paper
• Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats

  2006cited by this paper
• The antinociceptive effect of salvinorin A in mice.

  2006cited by this paper
• Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist.

  2006cited by this paper
• The mesolimbic dopamine reward circuit in depression.

  2006cited by this paper
• Neo-clerodane diterpenes from the hallucinogenic sage Salvia divinorum.

  2006cited by this paper
• The pharmacological effects of Salvia species on the central nervous system

  2006cited by this paper
• Pharmacokinetics of the plant‐derived κ‐opioid hallucinogen salvinorin A in nonhuman primates

  2005cited by this paper
• Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates.

  2005cited by this paper
• Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization.

  2005cited by this paper
• Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.

  2005cited by this paper
• New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors.

  2005cited by this paper
• Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum.

  2005cited by this paper
• Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to κ-Opioid Receptors†

  2005cited by this paper
• Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors

  2005cited by this paper
• Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery.

  2004cited by this paper
• Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum.

  2003cited by this paper
• Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A.

  2003cited by this paper
• Acute Physiologic and Chronic Histologic Changes in Rats and Mice Exposed to the Unique Hallucinogen Salvinorin A

  2003cited by this paper
• Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

  2002cited by this paper
• Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.

  2002cited by this paper
• Salvinorin C, a new neoclerodane diterpene from a bioactive fraction of the hallucinogenic Mexican mint Salvia divinorum.

  2001cited by this paper
• Antidepressant effects of the herb Salvia divinorum: a case report.

  2001cited by this paper
• Synthesis of Clerodane Diterpenoids and Related Compounds - Stereoselective Construction of the Decalin Skeleton with Multiple Contiguous Stereogenic Centers

  2000cited by this paper
• Salvia divinorum and salvinorin A: new pharmacologic findings.

  1994cited by this paper
• Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum

  1984cited by this paper
• Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.).

  1983cited by this paper
• Conformational study of acetylcholine receptor sites. II. Syntheses of the dl-1-methyl-3-acetoxy-trans-decahydroquinoline methiodides

  1969cited by this paper

• Rare but relevant: Ibogaine and cardiovascular complications-prolonged QT interval and ventricular arrhythmias.

  2026cites this paper
• Opioid Receptors in Psychedelia: Indirect Serotonergic Modulation of Direct KOR Activation by Salvinorin A.

  2026cites this paper
• Diels-Alder Reaction: A Versatile Synthetic Tool For the Synthesis of Terpenoids and Alkaloids: A review

  2025cites this paper
• Diterpenes of Salvia (2016–2024): phytochemistry and pharmacology

  2025cites this paper
• Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A.

  2024cites this paper
• A dive into natural leads against depression from family Lamiaceae

  2024cites this paper
• 2023 Julius Axelrod Symposium: Plant-Derived Molecules Acting on G Protein-Coupled Receptors

  2024cites this paper
• A chromosome level reference genome of Diviner’s sage (Salvia divinorum) provides insight into salvinorin A biosynthesis

  2024cites this paper
• An Update on the Implications of New Psychoactive Substances in Public Health

  2022cites this paper
• Natural Products: Therapeutic Properties and Beyond II

  2022cites this paper
• Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders

  2022cites this paper
• A Protecting‐Group‐Free Synthesis of (−)‐Salvinorin A

  2021cites this paper
• Exploring the phytochemical variation of non-volatile metabolites within three South African Salvia species using UPLC-MS fingerprinting and chemometric analysis.

  2021cites this paper
• Psychoactive plants and phytochemicals

  2021cites this paper
• Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples

  2021cites this paper
• Antinociceptive effect and mechanism of supercritical carbon dioxide extract of Aloysia gratissima leaves in mice

  2020cites this paper
• Salvinorin A Does Not Affect Seizure Threshold in Mice

  2020influential citation
• Hallucinations: diagnosis, neurobiology and clinical management

  2020cites this paper
• Hallucinations and Imagination

  2020cites this paper
• Alternative therapies for children’s with autism spectrum disorder

  2020cites this paper
• Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis.

  2019cites this paper
• Adverse pharmacokinetic interactions between illicit substances and clinical drugs

  2019cites this paper
• Diterpenoids of terrestrial origin.

  2019cites this paper
• Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs

  2019cites this paper
• Case series: Salvia divinorum as a potential addictive hallucinogen.

  2018cites this paper
• New opioid receptor modulators and agonists.

  2018cites this paper
• Autism Spectrum Disorders: Potential Neuro-Psychopharmacotherapeutic Plant-Based Drugs.

  2018cites this paper
• Total Synthesis of the Neoclerodane Diterpene Salvinorin A via an Intramolecular Diels-Alder Strategy.

  2018cites this paper
• Multifunctional Opioid Ligands.

  2018cites this paper
• A review of salvinorin analogs and their kappa-opioid receptor activity.

  2018cites this paper
• Antinociceptive effect of neo-clerodane diterpenes obtained from Baccharis flabellata.

  2018cites this paper
• Opioid receptors: drivers to addiction?

  2018cites this paper
• Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.

  2017cites this paper
• Studies with psychedelic drugs in human volunteers

  2017influential citation
• : Plant-derived molecules acting on GPCRs

  year unknowncites this paper