Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2006-02-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.0510610103PMID 16446432PMCID PMC1413660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular diversity and regulation of renal potassium channels.

  2005cited by this paper
• Charge Screening by Internal pH and Polyvalent Cations as a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels

  2005cited by this paper
• Potassium channel structures: do they conform?

  2004cited by this paper
• Regulation of AMPA receptor gating by ligand binding core dimers.

  2004cited by this paper
• Proton binding to proteins: pK(a) calculations with explicit and implicit solvent models.

  2004cited by this paper
• The Molecular Basis for the pH-activation Mechanism in the Channel-forming Bacterial Colicin E1*

  2003cited by this paper
• Identification of a Heteromeric Interaction That Influences the Rectification, Gating, and pH Sensitivity of Kir4.1/Kir5.1 Potassium Channels*

  2003cited by this paper
• Crystal Structure of the Potassium Channel KirBac1.1 in the Closed State

  2003cited by this paper
• Stabilization of the Activity of ATP-sensitive Potassium Channels by Ion Pairs Formed between Adjacent Kir6.2 Subunits

  2003cited by this paper
• Impaired Renal NaCl Absorption in Mice Lacking the ROMK Potassium Channel, a Model for Type II Bartter's Syndrome*

  2002cited by this paper
• Absence of Small Conductance K+ Channel (SK) Activity in Apical Membranes of Thick Ascending Limb and Cortical Collecting Duct in ROMK (Bartter's) Knockout Mice*

  2002cited by this paper
• Allosteric modulation of the mouse kir6.2 channel by intracellular H+ and ATP

  2002cited by this paper
• An inward rectifier K+ channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4‐Kir5.1 heteromeric channels

  2002cited by this paper
• Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution.

  2002cited by this paper
• An Amino Acid Triplet in the NH2 Terminus of Rat ROMK1 Determines Interaction with SUR2B*

  2001cited by this paper
• PKA site mutations of ROMK2 channels shift the pH dependence to more alkaline values.

  2000cited by this paper
• Phosphatidylinositol 4,5-Bisphosphate and Intracellular pH Regulate the ROMK1 Potassium Channel via Separate but Interrelated Mechanisms*

  2000cited by this paper
• In vivo formation of a proton‐sensitive K+ channel by heteromeric subunit assembly of Kir5.1 with Kir4.1

  2000cited by this paper
• pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.

  1999cited by this paper
• pH-dependent Gating of ROMK (Kir1.1) Channels Involves Conformational Changes in Both N and C Termini*

  1998cited by this paper
• pH-dependent modulation of the cloned renal K+ channel, ROMK.

  1998cited by this paper
• Is the secretory K channel in the rat CCT ROMK?

  1997cited by this paper
• A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.

  1997cited by this paper
• Two-sided action of protons on an inward rectifier K+ channel (IRK1)

  1997cited by this paper
• Control of cytosolic pH in two-cell mouse embryos: roles of H(+)-lactate cotransport and Na+/H+ exchange.

  1997cited by this paper
• Phosphorylation of the ATP-sensitive, Inwardly Rectifying K Channel, ROMK, by Cyclic AMP-dependent Protein Kinase (*)

  1996cited by this paper
• Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.

  1996cited by this paper
• Intracellular H+ inhibits a cloned rat kidney outer medulla K+ channel expressed in Xenopus oocytes.

  1995cited by this paper

• Genome mining yields new disease-associated ROMK variants with distinct defects

  2023cites this paper
• Genome mining yields putative disease-associated ROMK variants with distinct defects

  2023cites this paper
• Handbook of Ion Channels

  2023cites this paper
• Comparison of K+ Channel Families.

  2021cites this paper
• Hormonal Regulation of Epithelial Sodium Channel (ENaC) and Other Nonneuronal Epithelial Ion Channels

  2020cites this paper
• Three Decades of Chloride Intracellular Channel Proteins: From Organelle to Organ Physiology

  2018cites this paper
• Trafficking and Quality Control of Inward-Rectifying Potassium Channels in the Model Eukaryote Saccharomyces cerevisiae

  2018cites this paper
• Inwardly Rectifying K+ Currents in Cultured Oligodendrocytes from Rat Optic Nerve are Insensitive to pH

  2017cites this paper
• Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating

  2016cites this paper
• Computational Tools for Interpreting Ion Channel pH-Dependence

  2015cites this paper
• Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.

  2015cites this paper
• Druggability of the inward rectifier family: a hope for rare channelopathies?

  2014cites this paper
• The Molecular Biology of Renal K+ Channels

  2013cites this paper
• [Chemokines: new insights in the treatment of glaucoma and inflammatory diseases of the ocular surface].

  2013cites this paper
• Study of a glycine hinge in ATP-sensitive potassium channels

  2012cites this paper
• The M338T mutation of Kir1.1b (ROMK2) channel caused mistargeting in MDCK cells

  2012cites this paper
• Regulation of transport in the connecting tubule and cortical collecting duct.

  2012cites this paper
• Protein kinase C mediated pHi-regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism

  2012cites this paper
• Random mutagenesis screening indicates the absence of a separate H+-sensor in the pH-sensitive Kir channels

  2010cites this paper
• Separate Gating Mechanisms Mediate the Regulation of K2P Potassium Channel TASK-2 by Intra- and Extracellular pH*

  2010cites this paper
• Inwardly rectifying potassium channels: their structure, function, and physiological roles.

  2010cites this paper
• The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating

  2009cites this paper
• A comprehensive guide to the ROMK potassium channel: form and function in health and disease.

  2009cites this paper
• Structural changes in the cytoplasmic pore of the Kir1.1 channel during pHi-gating probed by FRET

  2009cites this paper
• Rearrangements in the Relative Orientation of Cytoplasmic Domains Induced by a Membrane-anchored Protein Mediate Modulations in Kv Channel Gating*

  2009cites this paper
• Long-pore Electrostatics in Inward-rectifier Potassium Channels

  2008cites this paper
• Destabilization of ATP-sensitive Potassium Channel Activity by Novel KCNJ11 Mutations Identified in Congenital Hyperinsulinism*

  2008cites this paper
• Molecular mechanism of pH sensing in KcsA potassium channels

  2008cites this paper
• Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels.

  2008cites this paper
• Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands.

  2007cites this paper
• H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels

  2007influential citation
• Control of pH and PIP2 Gating in Heteromeric Kir4.1/Kir5.1 Channels by H-Bonding at the Helix-Bundle Crossing

  2007cites this paper
• Molecular structure and regulation of the epithelial calcium channels TRPV5 and TRPV6.

  2007cites this paper
• Moving the pH Gate of the Kir1.1 Inward Rectifier Channel

  2007cites this paper
• Role of conserved glycines in pH gating of Kir1.1 (ROMK).

  2006cites this paper