Deoxyribonucleotides as genetic and metabolic regulators

No abstract is available for this paper.

• Publication year

  2014

• Venue

  The FASEB Journal

• Publication date

  2014-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.14-251249PMID 24928192PMCID PMC5395721
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)

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• The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.

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  2014cited by this paper
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  2014cited by this paper
• Mechanism of Allosteric Activation of SAMHD1 by dGTP

  2013cited by this paper
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  2013cited by this paper
• Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence.

  2013cited by this paper
• Reduction of dNTP levels enhances DNA replication fidelity in vivo.

  2013cited by this paper
• Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

  2013cited by this paper
• Cost of rNTP/dNTP pool imbalance at the replication fork

  2013cited by this paper
• Inhibition of DNA synthesis facilitates expansion of low‐complexity repeats

  2013cited by this paper
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  2013cited by this paper
• Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalis*♦

  2013cited by this paper
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  2013cited by this paper
• Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

  2013cited by this paper
• Pre-activation of the genome integrity checkpoint increases DNA damage tolerance

  2013cited by this paper
• Restricted 5′-End Gap Repair of HIV-1 Integration Due to Limited Cellular dNTP Concentrations in Human Primary Macrophages*

  2013cited by this paper
• GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1*

  2013cited by this paper
• p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

  2013cited by this paper
• The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

  2013cited by this paper
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  2013cited by this paper
• RNase H and post-replication repair protect cells from ribonucleotides incorporated in DNA

  2013cited by this paper
• Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels*

  2013cited by this paper
• Structure–function analysis of ribonucleotide bypass by B family DNA replicases

  2013cited by this paper
• Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

  2013cited by this paper
• Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

  2012cited by this paper
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  2012cited by this paper
• Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase*♦

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli

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  2010cited by this paper
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  2010cited by this paper
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  2010influential reference
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  2008cited by this paper
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  2008cited by this paper
• DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

  2008cited by this paper
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  2008cited by this paper
• Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

  2008cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Assessing the Metabolic Function of the MutT 8-Oxodeoxyguanosine Triphosphatase in Escherichia coli by Nucleotide Pool Analysis*

  2002cited by this paper
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  2002cited by this paper
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• Transcription Factor HusR (YnfL) Is a Novel Regulator for Hydroxyurea Sensitivity in Escherichia coli K-12

  2026cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
• dTMP imbalance through thymidylate 5′-phosphohydrolase activity induces apoptosis in triple-negative breast cancers

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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