Radiolabeled Cholinesterase Substrates: In Vitro Methods for Determining Structure-Activity Relationships and Identification of a Positron Emission Tomography Radiopharmaceutical for In Vivo Measurement of Butyrylcholinesterase Activity

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2001-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/00004647-200102000-00004PMID 11176278
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The ratio of acetylcholinesterase to butyrylcholinesterase influences the specificity of assays for each enzyme in human brain

  2005cited by this paper
• Do In Vitro Enzyme Kinetics Predict In Vivo Radiotracer Kinetics

  2001cited by this paper
• Brain Acetylcholinesterase Activity in Alzheimer Disease Measured by Positron Emission Tomography

  2000influential reference
• Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex

  2000cited by this paper
• N-Methyl-3-(1-hydroxy-5-[123I]iodopent-4-enyl)-4-acetoxypiperidine, a novel candidate of acetylcholinesterase activity imaging agent

  2000cited by this paper
• Kinetic Modeling of N-[11C]Methylpiperidin-4-yl Propionate: Alternatives for Analysis of an Irreversible Positron Emission Tomography Tracer for Measurement of Acetylcholinesterase Activity in Human Brain

  1999cited by this paper
• Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age

  1999influential reference
• Simplified methods for in vivo measurement of acetylcholinesterase activity in rodent brain.

  1999cited by this paper
• In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease

  1999cited by this paper
• N-[11C]methylpiperidine esters as acetylcholinesterase substrates: an in vivo structure-reactivity study.

  1998cited by this paper
• Syntheses of carbon-11 labeled piperidine esters as potential in vivo substrates for acetylcholinesterase.

  1998cited by this paper
• Ontogenetic differences in the regional and cellular acetylcholinesterase and butyrylcholinesterase activity in the rat brain.

  1998cited by this paper
• Ontogenetic differences in the regional and cellular acetylcholinesterase and butyrylcholinesterase activity in the rat brain

  1998cited by this paper
• Development of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease

  1998influential reference
• Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity.

  1998cited by this paper
• Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease.

  1997influential reference
• Synthesis of carbon-11- and fluorine-18-labeled 1-methyl-4-piperidyl-4'-fluorobenzoate and their biodistribution in mice.

  1996cited by this paper
• Plasma butyrylcholinesterase activity and cocaine half-life differ significantly in rhesus and squirrel monkeys.

  1996cited by this paper
• In vivo studies of acetylcholinesterase activity using a labeled substrate, N‐[11C]methylpiperdin‐4‐yl propionate ([11C]PMP)

  1996cited by this paper
• Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase

  1996cited by this paper
• Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease.

  1996cited by this paper
• Neurochemical Correlates of Dementia Severity in Alzheimer's Disease: Relative Importance of the Cholinergic Deficits

  1995cited by this paper
• In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog.

  1994cited by this paper
• Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia

  1994cited by this paper
• Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo.

  1994influential reference
• Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity.

  1993cited by this paper
• A simple synthesis of [11C]methyl triflate.

  1992influential reference
• Brain acetylcholinesterase after acute parathion poisoning: A comparative quantitative histochemical analysis post mortem

  1988cited by this paper
• Butyrylcholinesterase in Human Brain and Acetylcholinesterase in Human Plasma: Trace Enzymes Measured by Two‐Site Immunoassay

  1988influential reference
• Acetylcholinesterase in Huntington's and Alzheimer's Diseases: Simultaneous Enzyme Assay and Immunoassay of Multiple Brain Regions

  1988cited by this paper
• The temperature-dependence of human erythrocyte acetylcholinesterase activity is not affected by membrane cholesterol enrichment.

  1988cited by this paper
• Molecular Forms of Acetylcholinesterase and Butyrylcholinesterase in the Aged Human Central Nervous System

  1986influential reference
• Distributive pattern on butyrylcholinesterase in the fore- and mid-brain of the mouse.

  1984cited by this paper
• Distributive pattern on butyrylcholinesterase in the fore- and mid-brain of the mouse.

  1984influential reference
• Rate assay for determination of serum pseudo-cholinesterase activity.

  1983influential reference
• Esterification of N-protected .alpha.-amino acids with alcohol/carbodiimide/4-(dimethylamino)pyridine. Racemization of aspartic and glutamic acid derivatives

  1982cited by this paper
• ESTERIFICATION OF N-PROTECTED α-AMINO ACIDS WITH ALCOHOL/CARBODIIMIDE/4-(DIMETHYLAMINO)PYRIDINE. RACEMIZATION OF ASPARTIC AND GLUTAMIC ACID DERIVATIVES

  1982cited by this paper
• A new approach to determining cholinesterase activities in samples of whole blood.

  1978cited by this paper
• CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE

  1978influential reference
• General enzyme studies with a substrate-selective electrode: characterization of cholinesterases.

  1971influential reference
• The temperature activity relationships of serum cholinesterases

  1970cited by this paper
• An improved method for the estimation of cholinesterase activity in serum.

  1959influential reference
• Specificity, mode of action and distribution of cholinesterases.

  1951cited by this paper

• A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s disease

  2023cites this paper
• Molecular PET Imaging in Alzheimer’s Disease

  2022cites this paper
• Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC)

  2020cites this paper
• PET Imaging of Acetylcholinesterase

  2020cites this paper
• Butyrylcholinesterase as a biomarker in Alzheimer’s disease

  2020cites this paper
• Rutin restores neurobehavioral deficits via alterations in cadmium bioavailability in the brain of rats exposed to cadmium.

  2019cites this paper
• Regional vesicular acetylcholine transporter distribution in human brain: A [18F]fluoroethoxybenzovesamicol positron emission tomography study

  2018cites this paper
• Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer’s Disease

  2017cites this paper
• Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease

  2017cites this paper
• A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety

  2016cites this paper
• Synthesis and Preliminary Evaluation of Phenyl 4-123I-Iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer Disease Pathology

  2016cites this paper
• Synthesis of N‐[11C]Methyl‐4‐Piperidinyl Propionate ([11C]PMP)

  2015cites this paper
• (-)-[(18) F]Flubatine: evaluation in rhesus monkeys and a report of the first fully automated radiosynthesis validated for clinical use.

  2013cites this paper
• 3'-R/S-hydroxyvoacamine, a potent acetylcholinesterase inhibitor from Tabernaemontana divaricata.

  2013cites this paper
• Antioxidant and anticholinesterase activities of aqueous extract of Uraria picta (Jacq.) DC

  2013cites this paper
• DEVELOPMENT OF BUTYRYLCHOLINESTERASE LIGANDS FOR THE IMAGING OF NEUROLOGICAL DISORDERS

  2013influential citation
• Thioesters for the in vitro evaluation of agents to image brain cholinesterases

  2013cites this paper
• Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m.

  2013cites this paper
• Enhancement of anti-cholinesterase activity of Zingiber cassumunar essential oil using a microemulsion technique.

  2012cites this paper
• Inhibition of cholinesterase by essential oil from food plant.

  2012cites this paper
• Corrigendum to Characterization of potent anticholinesterase plant oil based microemulsion [Int. J. Pharm. 401 (2010) 32―40]

  2011cites this paper
• Cholinergic dysfunction after traumatic brain injury

  2011cites this paper
• Synthesis and Preliminary Evaluation of Piperidinyl and Pyrrolidinyl Iodobenzoates as Imaging Agents for Butyrylcholinesterase

  2011cites this paper
• Operational calixarene-based fluorescent sensing systems for choline and acetylcholine and their application to enzymatic reactions

  2011cites this paper
• Characterization of potent anticholinesterase plant oil based microemulsion.

  2010cites this paper
• Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples

  2010influential citation
• Piperidine-4-methanthiol ester derivatives for a selective acetylcholinesterase assay.

  2010cites this paper
• 1-11C-Methyl-4-Piperidinyl-N-Butyrate Radiation Dosimetry in Humans by Dynamic Organ-Specific Evaluation

  2008cites this paper
• Acetylcholine esterase activity in mild cognitive impairment and Alzheimer’s disease

  2008cites this paper
• Deficits of the cholinergic system in early AD.

  2008cites this paper
• Cerebral acetylcholinesterase imaging: development of the radioprobes.

  2007cites this paper
• Imaging of Cholinergic and Monoaminergic Neurochemical Changes in Neurodegenerative Disorders

  2007influential citation
• Tomographic visualization of cholinesterase

  2006cites this paper
• Imaging butyrylcholinesterase activity in Alzheimer's disease

  2006cites this paper
• Reply: Does the JFK revised coma recovery scale complement the FOUR score?

  2006cites this paper
• In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses

  2006cites this paper
• Evaluation of 18F-labeled acetylcholinesterase substrates as PET radiotracers.

  2005cites this paper
• Functional studies of cholinergic activity in normal and Alzheimer disease states by imaging technique.

  2004cites this paper
• Acetylcholinesterase imaging: its use in therapy evaluation and drug design.

  2004cites this paper
• Biodistribution and blood metabolism of 1-11C-methyl-4-piperidinyl n-butyrate in humans: an imaging agent for in vivo assessment of butyrylcholinesterase activity with PET.

  2004cites this paper
• N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography.

  2004cites this paper
• Predicting the success of a radiopharmaceutical for in vivo imaging of central nervous system neuroreceptor systems.

  2003cites this paper
• N-[(18)F]Fluoroethylpiperidinyl, N-[(18)F]fluoroethylpiperidinemethyl and N-[(18)F]fluoroethylpyrrolidinyl esters as radiotracers for acetylcholinesterase.

  2003cites this paper
• N-methylpiperidinemethyl, N-methylpyrrolidyl and N-methylpyrrolidinemethyl esters as PET radiotracers for acetylcholinesterase activity.

  2003cites this paper
• Toward an Early Diagnosis and Treatment of Alzheimer's Disease

  2003cites this paper
• Radiosynthesis and mouse brain distribution studies of [11C] CP-126,998: a PET ligand for in vivo study of acetylcholinesterase.

  2002cites this paper
• EFFECT OF STEREOCHEMISTRY ON ESTER HYDROLYSIS BY CHOLINESTERASES: IMPLICATIONS FOR RADIOTRACER DESIGN

  2001cites this paper