Metabolic acidosis stimulates the production of the antimicrobial peptide cathelicidin in rabbit urine.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  AJP - Renal Physiology

• Publication date

  2017-07-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajprenal.00701.2016PMID 28747361PMCID PMC7276924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
• What Keeps the Urinary Tract Sterile?: The Antimicrobial Peptide Cathelicidin Protects the Urinary Tract against Invasive Bacterial Infection. Nat Med 12: 636-640, 2006.

  2006cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1994cited by this paper
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  1991cited by this paper
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  1986cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1953cited by this paper
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