Both IL‐12 and IL‐18 contribute to small intestinal Th1‐type immunopathology following oral infection with Toxoplasma gondii, but IL‐12 is dominant over IL‐18 in parasite control

No abstract is available for this paper.

• Publication year

  2004

• Venue

  European Journal of Immunology

• Publication date

  2004-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.200424993PMID 15368276
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti-Interleukin-18 Therapy in Murine Models of Inflammatory Bowel Disease

  2003cited by this paper
• Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis : a comparative study with IL-12p40

  2003cited by this paper
• Interleukin-18 and host defense against infection.

  2003cited by this paper
• Lamina Propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Proinflammatory Response Against an Intracellular Pathogen1

  2002cited by this paper
• IL-18 Improves the Early Antimicrobial Host Response to Pneumococcal Pneumonia

  2002cited by this paper
• Treatment of T Cell-Dependent Experimental Colitis in SCID Mice by Local Administration of an Adenovirus Expressing IL-18 Antisense mRNA

  2002cited by this paper
• Generation of neutralizing mouse anti-mouse IL-18 antibodies for inhibition of inflammatory responses in vivo.

  2002cited by this paper
• Oral infection of C57BL/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease?

  2002cited by this paper
• Treatment of T Cell-Dependent Experimental Colitis in SCID Mice by Local Administration of an Adenovirus Expressing IL-18 Antisense mRNA1

  2002cited by this paper
• IL-18 Contributes to Host Resistance Against Infection with Pseudomonas aeruginosa Through Induction of IFN-γ Production1

  2002cited by this paper
• Infection Candida albicans against Disseminated Role of Interleukin-18 in Host Defense

  2001cited by this paper
• Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain.

  2001cited by this paper
• Interleukin-18 regulates both Th1 and Th2 responses.

  2001cited by this paper
• Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.

  2001cited by this paper
• Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.

  2001cited by this paper
• Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-181

  2001cited by this paper
• Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production

  2001cited by this paper
• Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.

  2001cited by this paper
• A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease1

  2001cited by this paper
• A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection1

  2001cited by this paper
• IL-12-Independent IFN-γ Production by T Cells in Experimental Chagas’ Disease Is Mediated by IL-181

  2001cited by this paper
• Functional Reconstitution and Regulation of IL-18 Activity by the IL-18Rβ Chain1

  2001cited by this paper
• Molecular Medicine Chlamydia Trachomatis Mouse Pneumonitis Lung Infection in Il-18 and Il-12 Knockout Mice: Il-12 Is Dominant over Il-18 for Protective Immunity

  2000cited by this paper
• Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control Cutaneous Leishmania major Infection1

  2000cited by this paper
• The costimulatory effect of IL‐18 on the induction of antigen‐specific IFN‐γ production by resting T cells is IL‐12 dependent and is mediated by up‐regulation of the IL‐12 receptor β2 subunit

  2000cited by this paper
• IL-10 Is Required for Prevention of Necrosis in the Small Intestine and Mortality in Both Genetically Resistant BALB/c and Susceptible C57BL/6 Mice Following Peroral Infection with Toxoplasma gondii1

  2000cited by this paper
• Role of Interleukin-18 (IL-18) during Lethal Shock: Decreased Lipopolysaccharide Sensitivity but Normal Superantigen Reaction in IL-18-Deficient Mice

  2000cited by this paper
• Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

  2000cited by this paper
• Chlamydia trachomatis Infection of Epithelial Cells Induces the Activation of Caspase-1 and Release of Mature IL-181

  2000cited by this paper
• TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii.

  1999cited by this paper
• In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection.

  1999cited by this paper
• Role of Interleukin-18 (IL-18) in Mycobacterial Infection in IL-18-Gene-Disrupted Mice

  1999cited by this paper
• TNF‐α, nitric oxide and IFN‐γ are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii

  1999cited by this paper
• Role of Endogenous Interleukin-18 in Resolving Wild-Type and Attenuated Salmonella typhimuriumInfections

  1999cited by this paper
• Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with VirulentSalmonella typhimurium

  1999cited by this paper
• Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice.

  1999cited by this paper
• Interleukin-18 Protects Mice against Acute Herpes Simplex Virus Type 1 Infection

  1999cited by this paper
• A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.

  1999cited by this paper
• IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

  1998cited by this paper
• Defective NK cell activity and Th1 response in IL-18-deficient mice.

  1998cited by this paper
• IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice.

  1998cited by this paper
• Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection

  1998cited by this paper
• IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

  1997cited by this paper
• IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production.

  1997cited by this paper
• IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

  1997cited by this paper
• A dichotomous role for nitric oxide during acute Toxoplasma gondii infection in mice.

  1997cited by this paper
• Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii

  1996cited by this paper
• Cloning of a new cytokine that induces IFN-gamma production by T cells.

  1995cited by this paper
• Studies on the role of interleukin-12 in acute murine toxoplasmosis.

  1995cited by this paper
• Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.

  1993cited by this paper
• Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.

  1988cited by this paper
• Toxoplasma gondii infection of the central nervous system. Use of the peroxidase-antiperoxidase method to demonstrate toxoplasma in formalin fixed, paraffin embedded tissue sections.

  1981cited by this paper

• Relationship between Serum Level and Gene Expression of IL-18 in Recurrent Miscarriage Iraqi Women Infected with Toxoplasmosis

  2024cites this paper
• IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii

  2023cites this paper
• A novel mRNA vaccine, TGGT1_278620 mRNA-LNP, prolongs the survival time in BALB/c mice with acute toxoplasmosis

  2023cites this paper
• IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii

  2023cites this paper
• Immune response against toxoplasmosis—some recent updates RH: Toxoplasma gondii immune response

  2022cites this paper
• Role of NLRP3 in patients infected with Toxoplasma gondii parasite

  2022cites this paper
• effects of toxoplasmosis infection on the levels of IL-18 and anti-ds-DNA antibodies in SLE patients

  2022cites this paper
• A Protective and Pathogenic Role for Complement During Acute Toxoplasma gondii Infection

  2021cites this paper
• IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

  2021cites this paper
• Innate Lymphoid Cells in Response to Intracellular Pathogens: Protection Versus Immunopathology

  2021cites this paper
• Evaluation of the oxidative stress in liver of mice vaccinated with gamma radiation-attenuated Toxoplasma gondii

  2021cites this paper
• RIPK3 Facilitates Host Resistance to Oral Toxoplasma gondii Infection

  2021cites this paper
• Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis

  2020cites this paper
• The effect of murine gene deficiencies on the outcome of Toxoplasma gondii infection

  2020cites this paper
• Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5

  2020cites this paper
• The role of macrophages in protective and pathological responses to Toxoplasma gondii

  2020cites this paper
• Adaptive immunity

  2020cites this paper
• RIPK3 facilitates host and pathogen interactions after oral Toxoplasma gondii infection

  2020cites this paper
• Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection

  2020cites this paper
• Comprehensive Kinetic Survey of Intestinal, Extra-Intestinal and Systemic Sequelae of Murine Ileitis Following Peroral Low-Dose Toxoplasma gondii Infection

  2019cites this paper
• Interleukin-18 in Health and Disease

  2019cites this paper
• Drug Carrier Systems for Anticancer Agents

  2019cites this paper
• TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-γ production and host resistance to Toxoplasma gondii

  2019cites this paper
• Organ Pathology and Associated IFN-γ and IL-10 Variations in Mice Infected with Toxoplasma gondii Isolate from Kenya

  2019cites this paper
• Prevalence of Toxoplasmosis in Thika region, Kenya and the Immunopathology associated with Toxoplasma gondii infection in BALB/c mice

  2019cites this paper
• Peroral Low-Dose Toxoplasma gondii Infection of Human Microbiota-Associated Mice — A Subacute Ileitis Model to Unravel Pathogen–Host Interactions

  2018cites this paper
• Group 1 innate lymphoid cells in Toxoplasma gondii infection

  2018cites this paper
• Protozoan Parasites and Type I IFNs

  2017cites this paper
• Human Intestinal Microbiota: Interaction Between Parasites and the Host Immune Response.

  2017cites this paper
• Intestinal, extra-intestinal and systemic sequelae of Toxoplasma gondii induced acute ileitis in mice harboring a human gut microbiota

  2017cites this paper
• Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity

  2017cites this paper
• Genetic susceptibility associated with toxoplasmosis; genetic polymorphism, molecular and immunological study

  2016cites this paper
• An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection

  2016cites this paper
• Molekulare Regulation der IL-10 Expression in inflammatorischen und regulatorischen T-Helfer-Zellen

  2016cites this paper
• Toxoplasma gondii : Immune Protection and Evasion

  2016cites this paper
• The gut mucosal immune response to Toxoplasma gondii

  2015cites this paper
• Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection.

  2015cites this paper
• Preventive Anti-CD2 Treatment does not Impair Parasite Control in a Murine Toxoplasmosis Model

  2015cites this paper
• Anti-Inflammatory Properties of NAP in Acute Toxoplasma Gondii-Induced Ileitis in Mice

  2015cites this paper
• Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis

  2015cites this paper
• Anticancer Agents: Drug Carrier Systems

  2015cites this paper
• Roles of dendritic cells in immunity to Toxoplasma gondii

  2014cites this paper
• The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis

  2014cites this paper
• Role of IL-22 in microbial host defense.

  2014cites this paper
• Role of Blimp-1 in programing Th effector cells into IL-10 producers

  2014cites this paper
• Pituitary Adenylate Cyclase-Activating Polypeptide Ameliorates Experimental Acute Ileitis and Extra-Intestinal Sequelae

  2014cites this paper
• How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1.

  2014cites this paper
• Apicomplexan infections in the gut

  2014cites this paper
• Parasite distribution and associated immune response during the acute phase of Toxoplasma gondii infection in sheep

  2014cites this paper
• Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii.

  2014cites this paper
• Do you see what I see: Recognition of protozoan parasites by Toll-like receptors.

  2013cites this paper
• Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?

  2013influential citation
• Toxoplasma gondii Soluble Tachyzoite Antigen Triggers Protective Mechanisms against Fatal Intestinal Pathology in Oral Infection of C57BL/6 Mice

  2013cites this paper
• Pro-inflammatory potential of Escherichia coli strains K12 and Nissle 1917 in a murine model of acute ileitis.

  2013cites this paper
• Regulation and Migratory Role of P-Selectin Ligands during Intestinal Inflammation

  2013cites this paper
• Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger

  2012cites this paper
• Treatment with interleukin-18 binding protein ameliorates Toxoplasma gondii-induced small intestinal pathology that is induced by bone marrow cell-derived interleukin-18.

  2012cites this paper
• FoxP3+ T regulatory cells in oral lichen planus and its correlation with the distinct clinical appearance of the lesions

  2012cites this paper
• Intraepithelial lymphocytes, goblet cells and VIP‐IR submucosal neurons of jejunum rats infected with Toxoplasma gondii

  2012cites this paper
• IL-23 in Infections, Inflammation, Autoimmunity and Cancer: Possible Role in HIV-1 and AIDS

  2012cites this paper
• Immune response and immunopathology during toxoplasmosis

  2012cites this paper
• Immune response and tissue cytoprotection: two sides of the same coin in immunopathology

  2011cites this paper
• Toxoplasma gondii effectors are master regulators of the inflammatory response.

  2011cites this paper
• Immunology of Toxoplasma gondii

  2011cites this paper
• Toxoplasma gondii -- Antigen presentation and interactions in the intestinal mucosa

  2011cites this paper
• Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

  2011cites this paper
• Innate Immunity Of The Intestinal Epithelium During Toxoplasma Gondii Infection

  2011cites this paper
• Papel de CCR5 na infecção oral por Toxoplasma gondii

  2010cites this paper
• Congenital infections with Trypanosoma cruzi or Toxoplasma gondii are associated with decreased serum concentrations of interferon-c and interleukin-18 but increased concentrations of interleukin-10

  2010cites this paper
• Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation

  2010cites this paper
• The immunobiology of the innate response to Toxoplasma gondii.

  2009cites this paper
• This information is current as Infection Toxoplasma gondii during Early Response of Mucosal Epithelial Cells

  2009cites this paper
• Gut commensal bacteria direct a protective immune response against the human pathogen Toxoplasma gondii

  2009cites this paper
• Gut commensal bacteria direct a protective immune response against Toxoplasma gondii.

  2009cites this paper
• Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

  2009cites this paper
• Toll-like receptors in CNS parasitic infections.

  2009cites this paper
• Early Response of Mucosal Epithelial Cells during Toxoplasma gondii Infection

  2009cites this paper
• Small intestinal inflammation following oral infection with Toxoplasma gondii does not occur exclusively in C57BL/6 mice: review of 70 reports from the literature.

  2009cites this paper
• Interactions between Epithelial Cells and Dendritic Cells in Bacterial Handling

  2008cites this paper
• The pathogenic role of intestinal flora in IBD and colon cancer.

  2008cites this paper
• Comparison of cholera toxin A2/B and murine interleukin-12 as adjuvants of Toxoplasma multi-antigenic SAG1-ROP2 DNA vaccine.

  2008cites this paper
• T cell expression of MyD88 is required for resistance to Toxoplasma gondii

  2008cites this paper
• Evaluation of the immune response elicited by multi-antigenic DNA vaccine expressing SAG1, ROP2 and GRA2 against Toxoplasma gondii.

  2008cites this paper
• CD2 deficiency partially prevents small bowel inflammation and improves parasite control in murine Toxoplasma gondii infection.

  2007cites this paper
• Interleukin-12, interleukin-23, and psoriasis: current prospects.

  2007cites this paper
• Adaptive Immunity and Genetics of the Host Immune Response

  2007cites this paper
• Cytokine regulation of immunopathology in toxoplasmosis

  2007cites this paper
• Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy

  2006cites this paper
• Gram-Negative Bacteria Aggravate Murine Small Intestinal Th1-Type Immunopathology following Oral Infection with Toxoplasma gondii1

  2006cites this paper
• gondii Toxoplasma following Oral Infection with Small Intestinal Th 1-Type Immunopathology Gram-Negative Bacteria Aggravate Murine Oliver Liesenfeld

  2006cites this paper
• INTERACTION BETWEEN HERPESVIRUSES AND GENETIC VARIATION IN SCHIZOPHRENIA PATHOGENESIS: A CANDIDATE GENE APPROACH

  2006cites this paper
• Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different.

  2005cites this paper
• NK Cells Help To Induce CD8+-T-Cell Immunity against Toxoplasma gondii in the Absence of CD4+ T Cells

  2005cites this paper
• Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

  2005cites this paper