Mechanisms Underlying Skeletal Muscle Weakness in Human Heart Failure: Alterations in Single Fiber Myosin Protein Content and Function

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Circulation: Heart Failure

• Publication date

  2009-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/CIRCHEARTFAILURE.109.876433PMID 19919996PMCID PMC2782533
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
• Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila.

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• Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats.

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• Skeletal muscle myofibrillar mRNA expression in heart failure: relationship to local and circulating hormones.

  2006cited by this paper
• Effect of strain on actomyosin kinetics in isometric muscle fibers.

  2006cited by this paper
• Depression of force production and ATPase activity in different types of human skeletal muscle fibers from patients with chronic heart failure.

  2005cited by this paper
• Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity.

  2005cited by this paper
• Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons.

  2005cited by this paper
• Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.

  2004cited by this paper
• Skeletal muscle unweighting: spaceflight and ground-based models.

  2003cited by this paper
• The effect of ageing and immobilization on structure and function of human skeletal muscle fibres.

  2003cited by this paper
• Resistance training on physical performance in disabled older female cardiac patients.

  2003cited by this paper
• Control of ubiquitination of proteins in rat tissues by ubiquitin conjugating enzymes and isopeptidases.

  2002cited by this paper
• Reactivity of Au with ultrathin Si layers: A photoemission study

  2001cited by this paper
• Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women.

  2001cited by this paper
• Skeletal muscle characteristics, muscle strength and thigh muscle area in patients before and after cardiac transplantation

  2001cited by this paper
• Functional heterogeneity of mammalian single muscle fibres: do myosin isoforms tell the whole story?

  2001cited by this paper
• Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure.

  2001cited by this paper
• Oxidative capacity of skeletal muscle in heart failure patients versus sedentary or active control subjects.

  2001cited by this paper
• Maximum specific force depends on myosin heavy chain content in rat diaphragm muscle fibers.

  2000cited by this paper
• Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: Mechanisms at the cellular and molecular levels

  2000cited by this paper
• Plasticity in Skeletal , Cardiac , and Smooth Muscle Invited Review : Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle

  2000cited by this paper
• Serial circulating concentrations of c‐reactive protein, interleukin (il)‐4, and il‐6 in patients with acute left heart decompensation

  1999cited by this paper
• Skeletal muscle myosin heavy chains in heart failure: correlation between magnitude of the isozyme shift, exercise capacity, and gas exchange measurements.

  1998cited by this paper
• Improvement of the measurements on skinned muscle fibres by fixation of the fibre ends with glutaraldehyde

  1998cited by this paper
• Skeletal muscle atrophy and peak oxygen consumption in heart failure.

  1997cited by this paper
• Altered expression of myosin heavy chain in human skeletal muscle in chronic heart failure.

  1997cited by this paper
• Daily energy expenditure in free-living heart failure patients.

  1997cited by this paper
• Skeletal muscle function and its relation to exercise tolerance in chronic heart failure.

  1997cited by this paper
• Specific changes in skeletal muscle myosin heavy chain composition in cardiac failure: differences compared with disuse atrophy as assessed on microbiopsies by high resolution electrophoresis.

  1996cited by this paper
• Smooth, cardiac and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro

  1994cited by this paper
• Management of ectopic atrial tachycardia.

  1993cited by this paper
• Factors contributing to the exercise limitation of heart failure.

  1993cited by this paper
• Neurophysiological Assessment of Skeletal Muscle Fatigue in Patients With Congestive Heart Failure

  1992cited by this paper
• Subcellular localization of newly incorporated myosin in rabbit fast skeletal muscle undergoing stimulation-induced type transformation

  1990cited by this paper
• Why animals have different muscle fibre types

  1988cited by this paper
• Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction.

  1988cited by this paper
• Effects of pH on contraction of rabbit fast and slow skeletal muscle fibers.

  1988cited by this paper
• Slow myosin in developing rat skeletal muscle

  1987influential reference
• Myosin degradation fragments in skeletal muscle.

  1987cited by this paper
• Firing patterns of motor units in normal rats

  1985cited by this paper
• Cardiac disability. The impact of coronary heart disease on patients' daily activities.

  1985cited by this paper
• Quatitative determination of myosin and actin in rabbit skeletal muscle

  1983cited by this paper
• Quantitative determination of myosin and actin in rabbit skeletal muscle.

  1983cited by this paper
• Influence of temperature upon contractile activation and isometric force production in mechanically skinned muscle fibers of the frog

  1982cited by this paper
• Relation of the Renin‐Angiotensin-Aldosterone System to Clinical State in Congestive Heart Failure

  1981cited by this paper
• Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.

  1979cited by this paper
• Notes on the estimation of the numerical density of arbitrary profiles: the edge effect

  1977cited by this paper
• REFINEMENTS IN METHOD OF EVALUATION AND PHYSICAL CONDITIONING BEFORE AND AFTER MYOCARDIAL INFARCTION.

  1964cited by this paper
• Muscle structure and theories of contraction.

  1957cited by this paper
• Intensive Care Medicine,

  year unknowncited by this paper

• Ultrasound-guided skeletal muscle biopsy technique permits measurement of structural, functional, cellular and biochemical properties

  2026cites this paper
• Engineered muscle drives bone repair and functional healing after composite musculoskeletal injury.

  2026cites this paper
• Association Between Chronic Diseases, Geriatric Syndromes, and Oral Health Problems in Older Adults Towards Strategising Optimum Oral Health Care: A Narrative Review

  2025influential citation
• Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis.

  2025cites this paper
• Influence of exercise and nutrition on sarcopenia in cardiovascular disease: A Scientific Statement of the European Association of Preventive Cardiology of the ESC.

  2025cites this paper
• Sustaining neuromuscular activation after total knee arthroplasty preserves skeletal muscle fiber size, contractility, and innervation in older adults

  2025influential citation
• Consolidating Concepts from Recent International Expert Consensus on Sarcopenia: Implications for Heart Failure Management.

  2025cites this paper
• Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog.

  2025cites this paper
• Impact of whole-body and skeletal muscle composition on peak oxygen uptake in heart failure: a systematic review and meta-analysis

  2024cites this paper
• Weakness acquired in the cardiac intensive care unit: still the elephant in the room?

  2024cites this paper
• A study of the mediating effect of decreased intrinsic capacity between symptoms and activities of daily living in elderly patients with heart failure

  2024cites this paper
• Fatiguing exercise reduces cellular passive Young's modulus in human vastus lateralis muscle

  2024influential citation
• Design Principles and Benefits of Spatially Explicit Models of Myofilament Function.

  2024cites this paper
• Phase Angle Is Associated With Handgrip Strength in Older Patients With Heart Failure

  2023cites this paper
• Skeletal muscle single fiber force production declines early in juvenile male mice with chronic kidney disease

  2023cites this paper
• Concurrent Negative Impact of Undernutrition and Heart Failure on Functional and Cognitive Recovery in Hip Fracture Patients

  2023cites this paper
• Physical Activity and Activities of Daily Living in Older Adult Patients With Heart Failure Admitted for Subacute Musculoskeletal Disease

  2023cites this paper
• Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals

  2023cites this paper
• Cardiovascular Responses to Static Handgrip Exercise and Post-Exercise Ischemia in Heart Failure with Preserved Ejection Fraction.

  2023cites this paper
• The Prevalence of Activities of Daily Living Impairment in Patients With Heart Failure: A Systematic Review and Meta-Analysis

  2022cites this paper
• The Duration of Thigh Tourniquet Use Associated With Anterior Cruciate Ligament Reconstruction Does Not Produce Cellular-Level Contractile Dysfunction of the Quadriceps Muscle at 3 Weeks After Surgery

  2022cites this paper
• Effects of total knee arthroplasty on skeletal muscle structure anD function at the cellular, organellar and molecular levels.

  2022cites this paper
• Skeletal Muscle Contractile Function in Heart Failure With Reduced Ejection Fraction—A Focus on Nitric Oxide

  2022cites this paper
• Clinical Frailty Score Predicts Long-Term Mortality and Hospitalization Due to Heart Failure After Implantation of Cardiac Implantable Electric Device.

  2021cites this paper
• Breakdown of Filamentous Myofibrils by the UPS–Step by Step

  2021cites this paper
• Skeletal muscle cellular contractile dysfunction after anterior cruciate ligament reconstruction contributes to quadriceps weakness at 6‐month follow‐up

  2021cites this paper
• Impairment in activities of daily living and readmission in older patients with heart failure: a cohort study

  2021cites this paper
• Heart Failure Severity Stratification Beyond INTERMACS Profiles: A Step Toward Optimal Left Ventricular Assist Device Timing.

  2021cites this paper
• Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice.

  2020cites this paper
• Heart Failure-Induced Myopathy : The Predictive Role of Altered Myokines ’ Profile

  2020cites this paper
• Muscular changes in animal models of heart failure with preserved ejection fraction: what comes closest to the patient?

  2020cites this paper
• Abnormal skeletal muscle blood flow, contractile mechanics and fibre morphology in a rat model of obese‐HFpEF

  2020cites this paper
• Alterations in Skeletal Muscle in Heart Failure

  2020cites this paper
• Skeletal muscle atrophy in heart failure with diabetes: from molecular mechanisms to clinical evidence

  2020cites this paper
• Physical Activity and Heart Failure: Taking Steps to Control a Major Public Health Burden

  2020influential citation
• rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy

  2020cites this paper
• Heart Failure–Induced Skeletal Muscle Wasting

  2020cites this paper
• Utility of Neuromuscular Electrical Stimulation to Preserve Quadriceps Muscle Fiber Size and Contractility After Anterior Cruciate Ligament Injuries and Reconstruction: A Randomized, Sham-Controlled, Blinded Trial

  2020cites this paper
• Effect of neuromuscular electrical stimulation on skeletal muscle size and function in patients with breast cancer receiving chemotherapy.

  2020cites this paper
• Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF).

  2019cites this paper
• Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation

  2019cites this paper
• Skeletal Muscle Fatigability in Heart Failure

  2019cites this paper
• Maintenance of skeletal muscle function following reduced daily physical activity in healthy older adults: a pilot trial.

  2019cites this paper
• Usefulness of Upper and Lower Limb Muscles Strength in the Evaluation of Clinical Severity of Heart Failure in Elderly Patients

  2019cites this paper
• A Novel Model Incorporating Pectoralis Muscle Measures To Predict Mortality After Ventricular Assist Device Implantation.

  2019cites this paper
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  2019cites this paper
• Quadriceps Lipid Content Has Sex-Specific Associations With Whole-Muscle, Cellular, and Molecular Contractile Function in Older Adults.

  2018cites this paper
• Skeletal muscle fiber characteristics in patients with chronic heart failure: impact of disease severity and relation with muscle oxygenation during exercise.

  2018cites this paper
• High‐intensity interval training prevents oxidantmediated diaphragm muscle weakness in hypertensive mice

  2017influential citation
• Directly Measured Physical Function in Cardiac Rehabilitation

  2017cites this paper
• Exercise-Based Rehabilitation for Heart Failure: Clinical Evidence.

  2017cites this paper
• Effects of cyanidin 3-0-glucoside on cardiac structure and function in an animal model of myocardial infarction.

  2017cites this paper
• Moderate-intensity resistance exercise alters skeletal muscle molecular and cellular structure and function in inactive older adults with knee osteoarthritis.

  2017influential citation
• Specific force in human single muscle fibres with specific reference to ageing

  2017cites this paper
• Foods, Nutrients and Food Ingredients with Authorised EU Health Claims : Volume 3

  2016cites this paper
• Skeletal muscle ultrastructure and function in statin‐tolerant individuals

  2016influential citation
• Dietary Nitrate and Skeletal Muscle Contractile Function in Heart Failure

  2016cites this paper
• Skeletal muscle fiber size and fiber type distribution in human cancer: Effects of weight loss and relationship to physical function.

  2016cites this paper
• Functional assessment of heart failure patients.

  2015influential citation
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  2015cites this paper
• Reduced rate of knee extensor torque development in older adults with knee osteoarthritis is associated with intrinsic muscle contractile deficits.

  2015cites this paper
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  2015cites this paper
• Chronic disuse and skeletal muscle structure in older adults: sex-specific differences and relationships to contractile function.

  2015cites this paper
• Skeletal Muscle Changes in Chronic Cardiac Disease and Failure.

  2015cites this paper
• Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.

  2015cites this paper
• Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure: A Double-Blind, Placebo-Controlled, Randomized Trial

  2015cites this paper
• Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans

  2014cites this paper
• Discerning Primary and Secondary Factors Responsible for Clinical Fatigue in Multisystem Diseases

  2014cites this paper
• Muscle disuse alters skeletal muscle contractile function at the molecular and cellular levels in older adult humans in a sex‐specific manner

  2014cites this paper
• Random myosin loss along thick-filaments increases myosin attachment time and the proportion of bound myosin heads to mitigate force decline in skeletal muscle.

  2014cites this paper
• Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function.

  2014cites this paper
• Age-related slowing of myosin actin cross-bridge kinetics is sex specific and predicts decrements in whole skeletal muscle performance in humans.

  2013influential citation
• Central and peripheral quadriceps fatigue in congestive heart failure☆

  2013cites this paper
• Metabolic and structural impairment of skeletal muscle in heart failure

  2013influential citation
• Skeletal muscle protein metabolism in human heart failure

  2013cites this paper
• Myofilament Protein Alterations Promote Physical Disability in Aging and Disease

  2013cites this paper
• Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa.

  2013cites this paper
• Molecular mechanisms underlying skeletal muscle weakness in human cancer: reduced myosin-actin cross-bridge formation and kinetics.

  2013influential citation
• Skeletal muscle mitochondrial density, gene expression, and enzyme activities in human heart failure: minimal effects of the disease and resistance training.

  2012cites this paper
• Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels

  2012influential citation
• Biphasic response of skeletal muscle mitochondria to chronic cardiac pressure overload - role of respiratory chain complex activity.

  2012cites this paper
• Determinantes da fraqueza e propriedades contráteis da musculatura inspiratória na insuficiência cardíaca

  2012cites this paper
• Chapter 74 – Thick and Thin Filament Proteins: Acquired and Hereditary Sarcomeric Protein Diseases

  2012cites this paper
• Thick and Thin Filament Proteins

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
• Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function.

  2011influential citation
• Effect of resistance training on physical disability in chronic heart failure.

  2011cites this paper
• Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy

  2011cites this paper
• Comparative Biomechanics of Thick Filaments and Thin Filaments with Functional Consequences for Muscle Contraction

  2010cites this paper
• Chronic heart failure decreases cross‐bridge kinetics in single skeletal muscle fibres from humans

  2010influential citation
• Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship with markers of immune activation.

  2010cites this paper
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