Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Current pharmaceutical design

• Publication date

  2017-07-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.2174/1381612823666170823103830PMID 28831925
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress.

  2016cited by this paper
• Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study.

  2014cited by this paper
• Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men

  2014cited by this paper
• Adiposity distribution influences circulating adiponectin levels.

  2014cited by this paper
• The relationship between sleep disorders and testosterone in men

  2014cited by this paper
• Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications

  2014cited by this paper
• Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes.

  2013cited by this paper
• Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

  2013cited by this paper
• Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study

  2013cited by this paper
• Testosterone as Potential Effective Therapy in Treatment of Obesity in Men with Testosterone Deficiency: A Review

  2012cited by this paper
• Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus.

  2011cited by this paper
• Age-related testosterone decline in a Brazilian cohort of healthy military men.

  2011cited by this paper
• Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study)

  2011cited by this paper
• Associations of endogenous testosterone and SHBG with glycated haemoglobin in middle‐aged and older men

  2011cited by this paper
• Low testosterone in men with type 2 diabetes: significance and treatment.

  2011cited by this paper
• Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79.

  2010cited by this paper
• Adverse events associated with testosterone administration.

  2010cited by this paper
• Dietary Advanced Glycation End Products and Aging

  2010cited by this paper
• Association of Testosterone and Sex Hormone–Binding Globulin With Metabolic Syndrome and Insulin Resistance in Men

  2010cited by this paper
• Differences in mouse models of diabetes mellitus in studies of male reproduction.

  2010cited by this paper
• Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double‐blinded placebo‐controlled Moscow study

  2010cited by this paper
• Metabolic profile changes in the testes of mice with streptozotocin-induced type 1 diabetes mellitus.

  2009cited by this paper
• Sex hormone-binding globulin and risk of type 2 diabetes in women and men.

  2009cited by this paper
• Demographic, physical and lifestyle factors associated with androgen status: the Florey Adelaide Male Ageing Study (FAMAS)

  2009cited by this paper
• Testosterone in obesity, metabolic syndrome and type 2 diabetes.

  2009cited by this paper
• Testosterone therapy increases sexual desire in ageing men with low–normal testosterone levels and symptoms of androgen deficiency

  2008cited by this paper
• Low testosterone levels are common and associated with insulin resistance in men with diabetes.

  2008cited by this paper
• Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men.

  2008cited by this paper
• Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor

  2008cited by this paper
• Testosterone Concentration in Young Patients With Diabetes

  2008cited by this paper
• The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes.

  2007cited by this paper
• Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus.

  2007cited by this paper
• Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men: European Prospective Investigation Into Cancer in Norfolk (EPIC-Norfolk) Prospective Population Study

  2007cited by this paper
• Androgens and Diabetes in Men

  2007cited by this paper
• Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes

  2007cited by this paper
• Low serum testosterone concentration in middle-aged men with type 2 diabetes.

  2007cited by this paper
• Effects of androgen deprivation on glycaemic control and on cardiovascular biochemical risk factors in men with advanced prostate cancer with diabetes

  2007cited by this paper
• RELATIONSHIP BETWEEN BMI, TOTAL TESTOSTERONE, SEX HORMONE-BINDING-GLOBULIN, LEPTIN, INSULIN AND INSULIN RESISTANCE IN OBESE MEN

  2006cited by this paper
• Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations.

  2006cited by this paper
• Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes.

  2006cited by this paper
• Low serum testosterone and mortality in male veterans.

  2006cited by this paper
• Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic

  2006cited by this paper
• Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.

  2006cited by this paper
• Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis.

  2006cited by this paper
• Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men.

  2006cited by this paper
• Oxidative stress, sperm survival and fertility control.

  2006cited by this paper
• The influence of testosterone on blood pressure and risk factors for cardiovascular disease in a black South African population.

  2006cited by this paper
• The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study.

  2006cited by this paper
• Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men.

  2005cited by this paper
• Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men.

  2005cited by this paper
• Risk factors in predicting a poor response to sildenafil citrate in elderly men with erectile dysfunction

  2005cited by this paper
• Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire.

  2005cited by this paper
• Androgens, insulin resistance and vascular disease in men

  2005cited by this paper
• Diabetes mellitus is associated with subnormal serum levels of free testosterone in men

  2005cited by this paper
• Free testosterone and risk for Alzheimer disease in older men

  2004cited by this paper
• Impact of diabetes mellitus on the severity of erectile dysfunction and response to treatment: analysis of data from tadalafil clinical trials

  2004cited by this paper
• Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthy middle-aged men.

  2003cited by this paper
• Hormonal profile in patients with congestive heart failure.

  2003cited by this paper
• Osteoporosis in men.

  2003cited by this paper
• Hypertension, anti‐hypertensive drug therapy and erectile dysfunction in diabetes

  2003cited by this paper
• Waist Circumference and Testosterone Levels in Community Dwelling Men. The Tromsø Study

  2003cited by this paper
• Laboratory evaluations of erectile dysfunction: an evidence based approach.

  2003cited by this paper
• Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study.

  2002cited by this paper
• Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study.

  2002cited by this paper
• Diabetes and advanced glycation endproducts

  2002cited by this paper
• Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality.

  2002cited by this paper
• Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.

  2001cited by this paper
• Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study

  2000cited by this paper
• Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study.

  2000cited by this paper
• Carbohydrate metabolism in the elderly

  2000cited by this paper
• Expression of functional leptin receptors in rodent Leydig cells.

  1999cited by this paper
• Issues in testosterone replacement in older men.

  1998cited by this paper
• Inverse correlation between serum testosterone and leptin in men.

  1998cited by this paper
• Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: The Telecom Study.

  1997cited by this paper
• Effect of diabetes mellitus upon male reproductive function.

  1997cited by this paper
• Androgens in men--uses and abuses.

  1996cited by this paper
• Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial.

  1996cited by this paper
• Leydig cells: endocrine, paracrine, and autocrine regulation.

  1994cited by this paper
• Effects of endogenous testosterone and estradiol on sexual behavior in normal young men.

  1994cited by this paper
• Effects of selected hormones on the motility of spermatozoa in the mouse vas deferens.

  1994cited by this paper
• Obesity, body fat distribution and sex hormones in men.

  1993cited by this paper
• Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension

  1993cited by this paper
• Evidence that androgen negative feedback regulates hypothalamic gonadotropin-releasing hormone impulse strength and the burst-like secretion of biologically active luteinizing hormone in men.

  1992cited by this paper
• Lower Endogenous Androgen Levels and Dyslipidemia in Men with Non-Insulin-Dependent Diabetes Mellitus

  1992cited by this paper
• Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study.

  1988cited by this paper
• Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men.

  1988cited by this paper
• Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.

  1981cited by this paper
• Temporary sterility produced in male mice by 5-thio-D-glucose.

  1975cited by this paper

• Edible Berries- An Update on Nutritional Composition and Health Benefits- Part III

  2025cites this paper
• Mechanism of the traditional Chinese medicine SMBJ alleviates diabetes mellitus-induced Leydig cell dysfunction in rats testes

  2025cites this paper
• Andropause in Diabetic and Non-diabetic Males: A Cross-Sectional Observational Study in Western India

  2024cites this paper
• Covid-19 Study, Diagnostic and Therapeutic Transition.

  2023cites this paper
• Sweet Bell Pepper: A Focus on Its Nutritional Qualities and Illness-Alleviated Properties

  2023cites this paper
• Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats

  2021cites this paper
• Health Science Community Will Miss This Bright and Uniting Star: In Memory of Professor Gjumrakch Aliev, M.D, Ph.D.

  2021cites this paper
• Medical Treatments for Chronic orAggressive Diseases, Palliative Therapy andNursery

  2020cites this paper
• Nursery education for diabetes

  2020cites this paper
• Natural drug cancer treatments, strategies from herbal medicine to chemical or biological drugs

  2020cites this paper
• Human Obesity and Diabetes, Is it Associated with COVID-19 Mortality

  2020cites this paper
• Nursery Science and Conventions

  2020cites this paper
• In Silico ADME-T Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes.

  2020cites this paper
• Nursery Education, Capability and Service Promotion

  2019cites this paper
• Obese Study , Keeping up Momentum

  2019cites this paper
• Nursery Service in Modern Days

  2019cites this paper
• Docking Studies of Epigallocatechin Gallate as Natural DPP-IV Inhibitor

  2019cites this paper
• Patient’s care and nursery in different diseases

  2019cites this paper
• Nursery service, quality promotion

  2019cites this paper
• Cosmetic Surgery Idea Conflicts

  2019cites this paper
• Introduction of Phytonutrients

  2019cites this paper
• Nursery training, from technique details in schools into medical knowledge education in nursery career

  2019cites this paper
• Metabolism of anthocyanins and consequent effects on the gut microbiota

  2018cites this paper
• Fruits as Prospective Reserves of bioactive Compounds: A Review

  2018cites this paper
• Antidiabetic potential of saffron and its active constituents

  2018cites this paper
• Type 2 Diabetes Study, Introduction and Perspective

  2018cites this paper
• Type 2 diabetes, medical knowledge and pharmaceutical innovations.

  2017cites this paper
• Editorial: The Aging Male: Physiology, Pathophysiology, and Therapeutic Perspectives.

  2017cites this paper