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Successful pregnancy by vitrified–warmed embryo transfer for a woman with Kallmann syndrome

Misato Shimoda,H. Iwayama,Mai Ishiyama,Ayano Nakatani,Masanori Yamashita

Published 2016 in Reproductive Medicine and Biology

ABSTRACT

AbstractPurposeKallmann syndrome is a genetic disorder characterized by hypogonadotropic hypogonadism and anosmia. We report the case of a 31-year-old woman with Kallmann syndrome who successfully gave birth after intracytoplasmic sperm injection (ICSI) and vitrified–warmed embryo transfer, despite relatively ineffective ovarian stimulation.MethodA 30 year-old woman with primary amenorrhea wished to achieve pregnancy. Diagnostic testing results were consistent with Kallmann syndrome. Follicular stimulation was started with human menopausal gonadotropin (hMG; 150 IU/day). After 28 days of treatment, 4 follicles were observed (total hMG; 4200 IU), with a dominant follicle diameter of 23 mm. Ovum pick-up was performed and 2 oocytes, one at metaphase II (MII) and one at the germinal vesicle stage, were obtained. Piezo-ICSI was performed on the MII oocyte and an 8-cell stage embryo was cryopreserved on day 3. Subsequently, embryo transfer was performed after endometrial preparation.ResultA gestational sac and embryo heart activity were confirmed by ultrasonographic monitoring, and a healthy male infant weighing 3246 g was delivered by Caesarean section after 41 weeks 3 days of gestation.ConclusionThis is the first report of a healthy delivery after vitrified–warmed embryo transfer for a woman with Kallmann syndrome. Our experience suggests that ICSI and vitrified–warmed embryo transfer are effective for women with Kallmann syndrome.

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