RNA editing activity is associated with splicing factors in lnRNP particles: The nuclear pre-mRNA processing machinery

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2001-05-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.111153798PMID 11381114PMCID PMC34394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Altered G Protein‐Coupling Functions of RNA Editing Isoform and Splicing Variant Serotonin2C Receptors

  2000cited by this paper
• Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.

  2000cited by this paper
• The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing.

  2000cited by this paper
• A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains.

  2000cited by this paper
• Flipping the Switch Minireview to an Active Spliceosome

  1999cited by this paper
• RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity*

  1999cited by this paper
• The RNA-editing Enzyme ADAR1 Is Localized to the Nascent Ribonucleoprotein Matrix on Xenopus Lampbrush Chromosomes but Specifically Associates with an Atypical Loop

  1999cited by this paper
• Inosine exists in mRNA at tissue‐specific levels and is most abundant in brain mRNA

  1998cited by this paper
• Concentrating dilute protein solutions for gel electrophoresis.

  1998cited by this paper
• RNA structure and function

  1998cited by this paper
• A supraspliceosome model for large nuclear ribonucleoprotein particles based on mass determinations by scanning transmission electron microscopy.

  1998cited by this paper
• RNP Particles, Splicing and Autoimmune Diseases

  1998cited by this paper
• Protein functions in pre-mRNA splicing.

  1997cited by this paper
• Regulation of serotonin-2C receptor G-protein coupling by RNA editing

  1997cited by this paper
• Automated electron tomography of large nuclear RNP (InRNP) particles--the naturally assembled complexes of precursor messenger RNA and splicing factors.

  1997cited by this paper
• A standardized nomenclature for adenosine deaminases that act on RNA.

  1997cited by this paper
• Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette.

  1997cited by this paper
• Three-dimensional image reconstruction of large nuclear RNP (lnRNP) particles by automated electron tomography.

  1997cited by this paper
• A guide to RNA editing.

  1997cited by this paper
• Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases

  1997cited by this paper
• Dramatic Increase of the RNA Editing for Glutamate Receptor Subunits During Terminal Differentiation of Clonal Human Neurons

  1997cited by this paper
• A mammalian RNA editing enzyme

  1996cited by this paper
• Editing of the GLuR‐B ion channel RNA in vitro by recombinant double‐stranded RNA adenosine deaminase.

  1996cited by this paper
• RED2, a Brain-specific Member of the RNA-specific Adenosine Deaminase Family*

  1996cited by this paper
• Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

  1996cited by this paper
• Phosphorylated Ser/Arg-rich proteins: limiting factors in the assembly of 200S large nuclear ribonucleoprotein particles.

  1996cited by this paper
• The structure and function of proteins involved in mammalian pre-mRNA splicing.

  1996cited by this paper
• Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase

  1995cited by this paper
• Magnesium cations are required for the association of U small nuclear ribonucleoproteins and SR proteins with pre-mRNA in 200 S large nuclear ribonucleoprotein particles.

  1995cited by this paper
• Mutagenic Analysis of Double-stranded RNA Adenosine Deaminase, a Candidate Enzyme for RNA Editing of Glutamate-gated Ion Channel Transcripts (*)

  1995cited by this paper
• Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase

  1995cited by this paper
• Purification and characterization of double-stranded RNA adenosine deaminase from bovine nuclear extracts.

  1994cited by this paper
• Control of kinetic properties of AMPA receptor channels by nuclear RNA editing.

  1994cited by this paper
• Heat shock affects 5' splice site selection, cleavage and ligation of CAD pre-mRNA in hamster cells, but not its packaging in InRNP particles.

  1994cited by this paper
• Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

  1994cited by this paper
• Dynamic RNA-RNA interactions in the spliceosome.

  1994cited by this paper
• RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency.

  1993cited by this paper
• SR proteins: a conserved family of pre-mRNA splicing factors.

  1992cited by this paper
• Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.

  1991cited by this paper
• RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.

  1991cited by this paper
• The Eukaryotic nucleus : Molecular biochemistry and macromolecular assemblies

  1990cited by this paper
• A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle

  1990cited by this paper
• Isolation and visualization of large compact ribonucleoprotein particles of specific nuclear RNAs.

  1989cited by this paper
• RNA world

  1987cited by this paper
• U1, U2, and U6 small nuclear ribonucleoproteins (snRNPs) are associated with large nuclear RNP particles containing transcripts of an amplified gene in vivo.

  1986cited by this paper
• Abundant nuclear ribonucleoprotein form of CAD RNA

  1985cited by this paper
• Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

  1981cited by this paper

• Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs.

  2025cites this paper
• ADAR1 regulates alternative splicing through an RNA editing-independent mechanism

  2025cites this paper
• ADBP-1 regulates ADR-2 nuclear localization to control editing substrate selection

  2024cites this paper
• ADBP-1 regulates ADR-2 nuclear localization to control editing substrate selection

  2024cites this paper
• The role of RNA-modifying proteins in renal cell carcinoma

  2024cites this paper
• Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities

  2021cites this paper
• Non-Canonical Functions of Splicing Factors in RNA Metabolism

  2020cites this paper
• Dynamic Supraspliceosomes Are Assembled on Different Transcripts Regardless of Their Intron Number and Splicing State

  2020cites this paper
• Small non-coding RNA within the endogenous spliceosome and alternative splicing regulation.

  2019cites this paper
• RNA editing in the forefront of epitranscriptomics and human health

  2019cites this paper
• Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation

  2018cites this paper
• Small RNA sequences derived from pre-microRNAs in the supraspliceosome

  2018cites this paper
• Beyond the Identification of Transcribed Sequences : Functional , Evolutionary and Expression Analysis 12

  2018cites this paper
• SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates

  2018cites this paper
• Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer

  2018cites this paper
• RNA editing in nascent RNA affects pre-mRNA splicing

  2018cites this paper
• The nuts and bolts of the endogenous spliceosome

  2017cites this paper
• RNA editing-dependent epitranscriptome diversity in cancer stem cells

  2017cites this paper
• Structural studies of the endogenous spliceosome - The supraspliceosome.

  2017cites this paper
• Mechanisms and implications of ADAR-mediated RNA editing in cancer.

  2017cites this paper
• Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing

  2016cites this paper
• Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

  2016cites this paper
• ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo

  2016cites this paper
• Etude de la régulation de l'expression des gènes par un ARN antisens

  2015cites this paper
• The dynamic epitranscriptome: A to I editing modulates genetic information

  2015cites this paper
• Supraspliceosomes at Defined Functional States Portray the Pre-Assembled Nature of the Pre-mRNA Processing Machine in the Cell Nucleus

  2014cites this paper
• The Supraspliceosome — A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus

  2014cites this paper
• Functional Impact of RNA editing and ADARs on regulation of gene expression: perspectives from deep sequencing studies

  2014cites this paper
• Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome

  2014cites this paper
• Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain

  2014cites this paper
• Exploring the transcriptome of the brain

  2014cites this paper
• Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR).

  2013cites this paper
• ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.

  2013cites this paper
• Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure

  2013cites this paper
• Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing

  2013cites this paper
• Single Cell Analysis of RNA-mediated Histone H3.3 Recruitment to a Cytomegalovirus Promoter-regulated Transcription Site*

  2013cites this paper
• RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation

  2012cites this paper
• Regulation of alternative splicing within the supraspliceosome.

  2012cites this paper
• ADARs: viruses and innate immunity.

  2012cites this paper
• A unique spatial arrangement of the snRNPs within the native spliceosome emerges from in silico studies.

  2012cites this paper
• RNA editing catalyzed by ADAR1 and its function in mammalian cells

  2011cites this paper
• Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action

  2011cites this paper
• Characterising new roles for APOBEC4 and ADAR deaminases

  2010cites this paper
• Molecular diversity through RNA editing: a balancing act.

  2010cites this paper
• Functions and regulation of RNA editing by ADAR deaminases.

  2010cites this paper
• A novel tissue-specific alternatively spliced form of the A-to-I RNA editing enzyme ADAR2

  2010cites this paper
• A potential role for initiator-tRNA in pre-mRNA splicing regulation

  2010cites this paper
• Heterogeneous Nuclear Ribonucleoprotein G Regulates Splice Site Selection by Binding to CC(A/C)-rich Regions in Pre-mRNA*

  2009cites this paper
• RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function.

  2008cites this paper
• The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus

  2008cites this paper
• Structure and function of the Pre-mRNA splicing machine.

  2008cites this paper
• Regulation of glutamate receptor B pre-mRNA splicing by RNA editing

  2007cites this paper
• Exploring the architecture of the intact supraspliceosome using electron microscopy.

  2007cites this paper
• Brain-specific small nucleolar RNAs

  2007cites this paper
• RNA-editing-mediated exon evolution

  2007cites this paper
• Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors

  2007cites this paper
• Molecular mechanisms of ADAR2 localization and substrate specificity.

  2006cites this paper
• Biochemical analysis of the Drosophila RNA editing enzyme ADAR and its functional domains

  2006cites this paper
• Substrate-dependent contribution of double-stranded RNA-binding motifs to ADAR2 function.

  2006cites this paper
• Native spliceosomes assemble with pre-mRNA to form supraspliceosomes.

  2006cites this paper
• Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase.

  2006cites this paper
• Altered RNA editing of serotonin 2C receptor in a rat model of depression.

  2005cites this paper
• Natural Antisense Transcripts

  2005cites this paper
• ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation.

  2005cites this paper
• Retention and repression: fates of hyperedited RNAs in the nucleus.

  2005cites this paper
• ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs

  2005cites this paper
• Widespread RNA editing of embedded alu elements in the human transcriptome.

  2004cites this paper
• Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy.

  2004cites this paper
• Effects of Length and Location on the Cellular Response to Double-Stranded RNA

  2004cites this paper
• Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene*

  2004cites this paper
• Building protein interaction maps for Down's syndrome.

  2004cites this paper
• Intracellular Localization of Differentially Regulated RNA-specific Adenosine Deaminase Isoforms in Inflammation*

  2003cites this paper
• Coordination of editing and splicing of glutamate receptor pre-mRNA.

  2003cites this paper
• Glutamate receptor RNA editing: a molecular analysis of GluR2, GluR5 and GluR6 in human brain tissues and in NT2 cells following in vitro neural differentiation.

  2003cites this paper
• p63α Mutations Lead to Aberrant Splicing of Keratinocyte Growth Factor Receptor in the Hay-Wells Syndrome*

  2003cites this paper
• Glucocorticoids Repress Transcription of Phosphoenolpyruvate Carboxykinase (GTP) Gene in Adipocytes by Inhibiting Its C/EBP-mediated Activation*

  2003cites this paper
• Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA*

  2003cites this paper
• Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2

  2003cites this paper
• Distinct in vivo roles for double-stranded RNA-binding domains of the Xenopus RNA-editing enzyme ADAR1 in chromosomal targeting

  2003cites this paper
• The dsRNA binding protein family: critical roles, diverse cellular functions

  2003cites this paper
• Modulation of RNA editing by functional nucleolar sequestration of ADAR2

  2003cites this paper
• A-to-I RNA Editing: Recent News and Residual Mysteries*

  2003cites this paper
• The challenge of target sequence specificity in C-->U RNA editing.

  2002cites this paper
• Large nuclear RNP particles--the nuclear pre-mRNA processing machine.

  2002cites this paper
• RNA polymerase II conducts a symphony of pre-mRNA processing activities.

  2002cites this paper
• RNA editing by adenosine deaminases generates RNA and protein diversity.

  2002cites this paper
• Conservation of an open-reading frame as an element affecting 5' splice site selection.

  2002cites this paper
• Defects in Pre-mRNA Processing as Causes of and Predisposition to Diseases

  2002cites this paper
• Cryoelectron microscopy and cryoelectron tomography of the nuclear pre-mRNA processing machine.

  2002cites this paper