Antiviral Strategies Against Chikungunya Virus

In the last few decades the Chikungunya virus (CHIKV) has evolved from a geographically isolated pathogen to a virus that is widespread in many parts of Africa, Asia and recently also in Central- and South-America. Although CHIKV infections are rarely fatal, the disease can evolve into a chronic stage, which is characterized by persisting polyarthralgia and joint stiffness. This chronic CHIKV infection can severely incapacitate patients for weeks up to several years after the initial infection. Despite the burden of CHIKV infections, no vaccine or antivirals are available yet. The current therapy is therefore only symptomatic and consists of the administration of analgesics, antipyretics, and anti-inflammatory agents. Recently several molecules with various viral or host targets have been identified as CHIKV inhibitors. In this chapter, we summarize the current status of the development of antiviral strategies against CHIKV infections.

• Publication year

  2015

• Venue

  Methods in molecular biology

• Publication date

  2015-12-28

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1007/978-1-4939-3618-2_22PMID 27233277PMCID 7121089
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thiazolidone derivatives as inhibitors of chikungunya virus.

  2015cited by this paper
• The green tea catechin, epigallocatechin gallate inhibits chikungunya virus infection.

  2015cited by this paper
• Cost-effectiveness of continuous erythropoietin receptor activator in anemia

  2014cited by this paper
• Respiratory syncytial virus: current and emerging treatment options

  2014cited by this paper
• Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

  2014cited by this paper
• Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo.

  2014cited by this paper
• Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response

  2014cited by this paper
• Arbidol as a broad-spectrum antiviral: An update

  2014cited by this paper
• Anti-Chikungunya Viral Activities of Aplysiatoxin-Related Compounds from the Marine Cyanobacterium Trichodesmium erythraeum

  2014cited by this paper
• New hepatitis C therapies: the toolbox, strategies, and challenges.

  2014cited by this paper
• Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication.

  2014cited by this paper
• Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

  2014cited by this paper
• A Phenotypic Assay to Identify Chikungunya Virus Inhibitors Targeting the Nonstructural Protein nsP2

  2013cited by this paper
• Chronic Joint Disease Caused by Persistent Chikungunya Virus Infection Is Controlled by the Adaptive Immune Response

  2013cited by this paper
• Administration of E2 and NS1 siRNAs Inhibit Chikungunya Virus Replication In Vitro and Protects Mice Infected with the Virus

  2013cited by this paper
• Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

  2013cited by this paper
• The C-Terminal Domain of Chikungunya Virus nsP2 Independently Governs Viral RNA Replication, Cytopathicity, and Inhibition of Interferon Signaling

  2013cited by this paper
• Chikungunya virus: an update on antiviral development and challenges

  2013cited by this paper
• Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.

  2013cited by this paper
• Favipiravir (T-705), a novel viral RNA polymerase inhibitor.

  2013cited by this paper
• Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication.

  2012cited by this paper
• Expression of Plasmid-Based shRNA against the E1 and nsP1 Genes Effectively Silenced Chikungunya Virus Replication

  2012cited by this paper
• Inhibition of Chikungunya Virus Replication by Harringtonine, a Novel Antiviral That Suppresses Viral Protein Expression

  2012influential reference
• The E2-E166K substitution restores Chikungunya virus growth in OAS3 expressing cells by acting on viral entry.

  2012influential reference
• Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cells

  2012cited by this paper
• Protein Kinase C: One Pathway towards the Eradication of Latent HIV-1 Reservoirs

  2012influential reference
• Chikungunya fever.

  2012cited by this paper
• In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant.

  2011cited by this paper
• Arthritis after infection with Chikungunya virus.

  2011cited by this paper
• Chikungunya virus isolates with/without A226V mutation show different sensitivity to IFN-a, but similar replication kinetics in non human primate cells.

  2011cited by this paper
• A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence.

  2011cited by this paper
• Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells.

  2011influential reference
• Chikungunya Virus Infection

  2011cited by this paper
• Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action.

  2011cited by this paper
• Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays

  2011cited by this paper
• Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol

  2011cited by this paper
• Biology and pathogenesis of chikungunya virus

  2010cited by this paper
• Chikungunya: an emerging and spreading arthropod-borne viral disease.

  2009cited by this paper
• The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus.

  2009cited by this paper
• Replication cycle of chikungunya: a re-emerging arbovirus.

  2009cited by this paper
• On Chikungunya Acute Infection and Chloroquine Treatment

  2008cited by this paper
• Inhibition of Chikungunya Virus Infection in Cultured Human Muscle Cells by Furin Inhibitors

  2008cited by this paper
• RNA interference mediated inhibition of Chikungunya virus replication in mammalian cells.

  2008cited by this paper
• 5'-Triphosphate RNA Is the Ligand for RIG-I

  2006cited by this paper
• The Anti-Yellow Fever Virus Activity of Ribavirin Is Independent of Error-Prone Replication

  2006cited by this paper
• RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

  2006cited by this paper
• Chikungunya Fever

  2005cited by this paper
• In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination.

  2004influential reference
• Chloroquine phosphate treatment of chronic Chikungunya arthritis. An open pilot study.

  1984cited by this paper
• Chloroquine phosphate treatment of chronic Chikungunya arthritis. An open pilot study.

  1984cited by this paper
• ANTIVIRAL ACTION AND SELECTIVITY OF 6‐AZAURIDINE

  1977cited by this paper

• Antiviral potential of Tualang honey in Chikungunya virus-infected human synoviocytes.

  2025cites this paper
• Maternal–Fetal Implications of Chikungunya Virus Infection: An Updated Review

  2025cites this paper
• Recent Advances in the Role of Different Nanoparticles in the Various Biosensors for the Detection of the Chikungunya Virus

  2024cites this paper
• Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection

  2024cites this paper
• Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity

  2023cites this paper
• EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT OF CHIKUNGUNYA - A REVIEW

  2023cites this paper
• Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis.

  2022cites this paper
• Development and Application of Treatment for Chikungunya Fever

  2022cites this paper
• Discovery of a Potent and Selective Chikungunya Virus Envelope Protein Inhibitor through Computer-Aided Drug Design.

  2021cites this paper
• In vitro Studies on The Inhibition of Replication of Zika and Chikungunya Viruses by Dolastane Isolated from Seaweed Canistrocarpus cervicornis

  2020cites this paper
• Exploiting Nanotechnology to Target Viruses

  2020cites this paper
• Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus

  2020cites this paper
• Arboviruses related with chronic musculoskeletal symptoms.

  2020cites this paper
• Evaluation of medicinal herbs for Anti-CHIKV activity.

  2019cites this paper
• Identification of Chikungunya virus nucleocapsid core assembly modulators

  2019cites this paper
• Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): A prospective cohort study

  2019cites this paper
• Immunoglobulin Therapy in a Patient With Severe Chikungunya Fever and Vesiculobullous Lesions

  2019cites this paper
• Emergence and treatment of chikungunya arthritis

  2018cites this paper
• Outbreak Of Chikungunya Virus In Karachi, Pakistan.

  2018cites this paper
• The neurological manifestations of Zika and chikungunya viruses

  2018cites this paper
• The neurological complications of chikungunya virus: A systematic review

  2018cites this paper
• Neurotropisme du Chikungunya : devenir à long terme d’une cohorte pédiatrique

  2018cites this paper
• Nanotechnology: A promising approach of antiviral treatments against chikungunya virus (CHIKV)

  2018cites this paper
• Treatment of chikungunya musculoskeletal disorders: a systematic review

  2018cites this paper
• Review: Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management

  2018cites this paper
• Could Hair Loss be a Relevant Symptom Associated with Chikungunya?

  2017cites this paper
• Antiviral Activity of Nobiletin against Chikungunya virus in vitro

  2017cites this paper
• Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus.

  2017cites this paper
• Antiviral activity of cationic amphiphilic drugs

  2017cites this paper
• Potential entry inhibitors of the envelope protein (E2) of Chikungunya virus: in silico structural modeling, docking and molecular dynamic studies

  2017cites this paper
• Chikungunya Virus Infection: An Update on Joint Manifestations and Management

  2016cites this paper