(Pro)renin receptor as a new drug target.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Current pharmaceutical design

• Publication date

  2011-10-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/138161211798220963PMID 22074431
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension

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• Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor‐β1 – connective tissue growth factor signalling cascade

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• Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study

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• Soluble Form of the (Pro)Renin Receptor Is Augmented in the Collecting Duct and Urine of Chronic Angiotensin II–Dependent Hypertensive Rats

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• A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals

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• Requirement of Prorenin Receptor and Vacuolar H+-ATPase–Mediated Acidification for Wnt Signaling

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• Expression of (Pro)renin Receptor in the Human Brain and Pituitary, and Co‐localisation with Arginine Vasopressin and Oxytocin in the Hypothalamus

  2010cited by this paper
• Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor.

  2010cited by this paper
• Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy.

  2010cited by this paper
• A redox switch in angiotensinogen modulates angiotensin release

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• Involvement of the Brain (Pro)renin Receptor in Cardiovascular Homeostasis

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• The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H+-ATPase Assembly in Murine Cardiomyocytes

  2010cited by this paper
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• The (Pro)Renin Receptor: Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney

  2009cited by this paper
• Prorenin has high affinity multiple binding sites for (pro)renin receptor.

  2009cited by this paper
• Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma

  2009cited by this paper
• Association of (Pro)renin Receptor mRNA Expression with Angiotensin-Converting Enzyme mRNA Expression in Human Artery

  2009cited by this paper
• (Pro)renin Receptor–Mediated Signal Transduction and Tissue Renin-Angiotensin System Contribute to Diabetes-Induced Retinal Inflammation

  2009cited by this paper
• 'Decoy peptide' region (RIFLKRMPSI) of prorenin prosegment plays a crucial role in prorenin binding to the (pro)renin receptor.

  2009cited by this paper
• Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men: the Ohasama study.

  2009cited by this paper
• A role of the (pro)renin receptor in neuronal cell differentiation.

  2009cited by this paper
• (Pro)Renin Receptor Peptide Inhibitor “Handle-Region” Peptide Does Not Affect Hypertensive Nephrosclerosis in Goldblatt Rats

  2008cited by this paper
• Prorenin anno 2008

  2008cited by this paper
• Prorenin and the (pro)renin receptor in ocular pathology.

  2008cited by this paper
• The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling.

  2008cited by this paper
• (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system.

  2008cited by this paper
• Cardiovascular effects of prorenin blockade in genetically spontaneously hypertensive rats on normal and high-salt diet.

  2008cited by this paper
• Prorenin and Renin-Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide

  2008cited by this paper
• Characterization of a functional (pro)renin receptor in rat brain neurons

  2008cited by this paper
• Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells.

  2007cited by this paper
• Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization.

  2007cited by this paper
• Renin receptor expression in human adipose tissue.

  2007cited by this paper
• Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats.

  2007cited by this paper
• Prorenin and the (pro)renin receptor--an update.

  2007cited by this paper
• Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade.

  2007cited by this paper
• Prorenin levels in retinopathy of prematurity.

  2007cited by this paper
• Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor

  2007cited by this paper
• Cardiovascular effects of nonproteolytic activation of prorenin.

  2006cited by this paper
• Nonproteolytic Activation of Prorenin Contributes to Development of Cardiac Fibrosis in Genetic Hypertension

  2006cited by this paper
• Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin.

  2006cited by this paper
• Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage.

  2006cited by this paper
• Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats.

  2006cited by this paper
• Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice.

  2006cited by this paper
• Elevated Blood Pressure and Heart Rate in Human Renin Receptor Transgenic Rats

  2006cited by this paper
• Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.

  2006cited by this paper
• A Novel Signal Transduction Cascade Involving Direct Physical Interaction of the Renin/Prorenin Receptor With the Transcription Factor Promyelocytic Zinc Finger Protein

  2006cited by this paper
• A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor.

  2005cited by this paper
• Weight Loss and the Renin-Angiotensin-Aldosterone System

  2005cited by this paper
• Renin, prorenin and the putative (pro)renin receptor.

  2005cited by this paper
• Angiotensin II type 1 receptor blockers reduce tissue factor activity and plasminogen activator inhibitor type-1 antigen in hypertensive patients: a randomized, double-blind, placebo-controlled study.

  2004cited by this paper
• Renin/prorenin-receptor biochemistry and functional significance

  2004cited by this paper
• Renin-angiotensin system components and endothelial proteins as markers of diabetic microvascular disease

  2004cited by this paper
• Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin.

  2004cited by this paper
• Human Prorenin Has “Gate and Handle” Regions for Its Non-proteolytic Activation*

  2003cited by this paper
• Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

  2002cited by this paper
• Prorenin Accumulation and Activation in Human Endothelial Cells: Importance of Mannose 6-Phosphate Receptors

  2001cited by this paper
• High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin.

  2001cited by this paper
• Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus

  1999cited by this paper
• Angiotensin II receptors.

  1999cited by this paper
• [Evidence of a renin receptor on human mesangial cells: effects on PAI1 and cGMP].

  1998cited by this paper
• Identification and Characterization of a Novel 9.2-kDa Membrane Sector-associated Protein of Vacuolar Proton-ATPase from Chromaffin Granules*

  1998cited by this paper
• Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen.

  1996cited by this paper
• Cathepsin B is a prorenin processing enzyme.

  1996cited by this paper
• Pathophysiological significance of plasma total renin and prorenin in patients with diabetes mellitus.

  1995cited by this paper
• Proteolytic processing of human prorenin in renal and non-renal tissues.

  1994cited by this paper
• Reversible cryoactivation of recombinant human prorenin.

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• Source of plasma prorenin in early and late pregnancy: observations in a patient with primary ovarian failure.

  1987cited by this paper
• Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications.

  1985cited by this paper

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