Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporter

No abstract is available for this paper.

• Publication year

  2000

• Venue

  FEBS Letters

• Publication date

  2000-12-29

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0014-5793(00)02372-3PMID 11150527
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter.

  2000cited by this paper
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• A target for cholesterol absorption inhibitors in the enterocyte brush border membrane.

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• Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.

  1998cited by this paper
• Inhibition of cholesterol absorption with CP‐148,623 lowers serum cholesterol in humans

  1997cited by this paper
• In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461.

  1997cited by this paper
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• Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type.

  1996cited by this paper
• 2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.

  1996cited by this paper
• Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461.

  1995cited by this paper
• Effect of the cholesterol absorption inhibitor SCH48461 in combination with the HMG-CoA reductase inhibitor lovastatin in rabbits, dogs and rhesus monkeys

  1994cited by this paper
• 2-Azetidinones as inhibitors of cholesterol absorption.

  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1974cited by this paper
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• Observations concerning the production and excretion of cholesterol in mammals. XIII. Role of chylomicra in transport of cholesterol and lipid.

  1954cited by this paper
• Observations concerning the production and excretion of cholesterol in animals. XI. The intestinal site of absorption and excretion of cholesterol.

  1953cited by this paper

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• [Selective cholesterol absorption inhibition as a new prospect in treatment of hypercholesterolemia].

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• Biliary cholesterol secretion in mice

  2005influential citation
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• PURIFIED 145 kDa-PROTEIN, ABLE TO BIND CHOLESTEROL AND/OR INHIBITORS OF CHOLESTEROL ABSORPTION, METHODS OF ITS OBTAINING AND PURIFICATION AND APPLICATION OF kDa-PROTEIN

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  2002cites this paper
• INHIBITION OF CHOLESTEROL ABSORPTION BY SCH 58053 IN THE MOUSE IS NOT MEDIATED VIA CHANGES IN EITHER THE INTESTINAL BILE ACID POOL OR THE EXPRESSION OF mRNA FOR ABCA1, ABCG5 OR ABCG8 IN THE ENTEROCYTE

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  2000cites this paper