Sphingosine 1‐phosphate receptor 1 is required for retinal ganglion cell survival after optic nerve trauma

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Neurochemistry

• Publication date

  2016-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/jnc.13701PMID 27309795
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells.

  2024cited by this paper
• Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System.

  2016influential reference
• Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3

  2015cited by this paper
• Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling.

  2015influential reference
• Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve

  2014cited by this paper
• The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity

  2014cited by this paper
• Hypothalamic S1P/S1PR1 axis controls energy homeostasis

  2014cited by this paper
• Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

  2014cited by this paper
• The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration

  2014influential reference
• FTY720 protects retinal ganglion cells in experimental glaucoma.

  2014influential reference
• Neutrophils Express Oncomodulin and Promote Optic Nerve Regeneration

  2013cited by this paper
• Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration

  2013influential reference
• Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve.

  2013cited by this paper
• Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve

  2013cited by this paper
• Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

  2013cited by this paper
• Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.

  2012cited by this paper
• Intrinsically photosensitive retinal ganglion cells are resistant to N-methyl-D-aspartic acid excitotoxicity

  2012cited by this paper
• Involvement of Caspase-6 and Caspase-8 in Neuronal Apoptosis and the Regenerative Failure of Injured Retinal Ganglion Cells

  2011cited by this paper
• Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina

  2011cited by this paper
• Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

  2011cited by this paper
• Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

  2010cited by this paper
• Phosphorylation of the Immunomodulator FTY720 Inhibits Programmed Cell Death of Fibroblasts Via the S1P3 Receptor Subtype and Bcl-2 Activation

  2010cited by this paper
• KLF Family Members Regulate Intrinsic Axon Regeneration Ability

  2009cited by this paper
• Oncomodulin links inflammation to optic nerve regeneration

  2009cited by this paper
• Sphingosine‐1‐phosphate receptors mediate neuromodulatory functions in the CNS

  2009cited by this paper
• Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

  2008cited by this paper
• ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells.

  2008cited by this paper
• Enhanced Survival of Melanopsin-expressing Retinal Ganglion Cells After Injury is Associated with the PI3 K/Akt Pathway

  2008cited by this paper
• Involvement of Sphingosine-1-Phosphate in Glutamate Secretion in Hippocampal Neurons

  2007cited by this paper
• A role for S1P signalling in axon guidance in the Xenopus visual system

  2007influential reference
• Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

  2007cited by this paper
• Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation.

  2007influential reference
• Sphingosine 1-Phosphate (S1P) Signaling Is Required for Maintenance of Hair Cells Mainly via Activation of S1P2

  2007cited by this paper
• Interactive effects of C3, cyclic AMP and ciliary neurotrophic factor on adult retinal ganglion cell survival and axonal regeneration.

  2007cited by this paper
• Morphological properties of mouse retinal ganglion cells.

  2006cited by this paper
• Insulin-like Growth Factors Mediate Heterotrimeric G Protein-dependent ERK1/2 Activation by Transactivating Sphingosine 1-Phosphate Receptors*

  2006cited by this paper
• Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo.

  2006cited by this paper
• Melanopsin-expressing retinal ganglion cells are more injury-resistant in a chronic ocular hypertension model.

  2006cited by this paper
• AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells

  2006cited by this paper
• Essential Role for Sphingosine Kinases in Neural and Vascular Development

  2005cited by this paper
• Extracellular signal‐regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo

  2005cited by this paper
• Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.

  2005cited by this paper
• Application of Rho Antagonist to Neuronal Cell Bodies Promotes Neurite Growth in Compartmented Cultures and Regeneration of Retinal Ganglion Cell Axons in the Optic Nerve of Adult Rats

  2005cited by this paper
• Counteracting the Nogo Receptor Enhances Optic Nerve Regeneration If Retinal Ganglion Cells Are in an Active Growth State

  2004cited by this paper
• Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft.

  2004cited by this paper
• Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

  2004cited by this paper
• Switching Mature Retinal Ganglion Cells to a Robust Growth State In Vivo: Gene Expression and Synergy with RhoA Inactivation

  2004cited by this paper
• Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons.

  2003cited by this paper
• Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo.

  2003cited by this paper
• Sphingosine-1-phosphate: an enigmatic signalling lipid

  2003cited by this paper
• Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation

  2003cited by this paper
• mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†

  2003cited by this paper
• The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors*

  2002cited by this paper
• TrkB Gene Transfer Protects Retinal Ganglion Cells from Axotomy-Induced Death In Vivo

  2002cited by this paper
• Bcl-2 Overexpression Does Not EnhanceIn Vivo Axonal Regeneration of Retinal Ganglion Cells after Peripheral Nerve Transplantation in Adult Mice

  2002cited by this paper
• Bcl-2 overexpression does not enhance in vivo axonal regeneration of retinal ganglion cells after peripheral nerve transplantation in adult mice

  2002influential reference
• Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells*

  2001cited by this paper
• Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats.

  2001cited by this paper
• Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture.

  2000cited by this paper
• Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3 In Vivo

  2000cited by this paper
• Brain-Derived Neurotrophic Factor-Mediated Neuroprotection of Adult Rat Retinal Ganglion Cells In Vivo Does Not Exclusively Depend on Phosphatidyl-Inositol-3′-Kinase/Protein Kinase B Signaling

  2000cited by this paper
• Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve

  2000cited by this paper
• Activation of caspase‐3 in axotomized rat retinal ganglion cells in vivo

  1999cited by this paper
• Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration

  1999cited by this paper
• Optic Nerve Crush: Axonal Responses in Wild-Type and bcl-2 Transgenic Mice

  1999cited by this paper
• Enzymatic measurement of sphingosine 1-phosphate.

  1999cited by this paper
• Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve.

  1999cited by this paper
• Expression of Specific Tubulin Isotypes Increases during Regeneration of Injured CNS Neurons, But Not after the Application of Brain-Derived Neurotrophic Factor (BDNF)

  1997cited by this paper
• Sphingosine‐1‐phosphate rapidly induces Rho‐dependent neurite retraction: action through a specific cell surface receptor.

  1996cited by this paper
• Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats

  1994influential reference
• Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.

  1994cited by this paper
• Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats.

  1993cited by this paper

• Retrospective OCT Analysis of Sphingosine-1-Phosphate Modulator Fingolimod in Multiple Sclerosis

  2025cites this paper
• The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

  2025cites this paper
• IL-33 protects retinal structure and function via mTOR/S6 signaling pathway in optic nerve crush.

  2024cites this paper
• The role of sphingosine-1-phosphate in autophagy and related disorders

  2023cites this paper
• S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun/Bim cascade and Bad phosphorylation in a mouse model of glaucoma

  2022cites this paper
• Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.

  2022cites this paper
• Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma

  2022cites this paper
• Sphingolipids as critical players in retinal physiology and pathology.

  2021cites this paper
• DNA-based eyelid trait prediction in Chinese Han population

  2021cites this paper
• Updates on sphingolipids: Spotlight on retinopathy.

  2021cites this paper
• Sphingosine 1-phosphate, a potential target in neovascular retinal disease

  2021cites this paper
• Sphingolipids as critical players in retinal physiology and pathology

  2020cites this paper
• Nogo-A-targeting antibody promotes visual recovery and inhibits neuroinflammation after retinal injury

  2020cites this paper
• Sphingosine 1‐phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer

  2020cites this paper
• The ceramide-S1P pathway as a druggable target to alleviate peripheral neuropathic pain

  2020cites this paper
• Sphingolipids as Emerging Mediators in Retina Degeneration

  2019cites this paper
• Return of function after CNS axon regeneration: Lessons from injury-responsive intrinsically photosensitive and alpha retinal ganglion cells.

  2019influential citation
• Metformin protects against sevoflurane-induced neuronal apoptosis through the S1P1 and ERK signaling pathways.

  2018cites this paper
• Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry

  2018cites this paper
• Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APPswe/PS1ΔE9 mice.

  2017influential citation
• Sphingosine 1-Phosphate Receptor 1 Modulates CNTF-Induced Axonal Growth and Neuroprotection in the Mouse Visual System

  2017cites this paper
• Nogo-A in the visual system development and in ocular diseases.

  2017cites this paper
• The S1P1 receptor‐selective agonist CYM‐5442 protects retinal ganglion cells in endothelin‐1 induced retinal ganglion cell loss

  2017cites this paper