Early administration of fluvastatin, but not at the onset of ischemia or reperfusion, attenuates myocardial ischemia-reperfusion injury through the nitric oxide pathway rather than its antioxidant property.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Circulation Journal

• Publication date

  2006-11-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1253/CIRCJ.70.1643PMID 17127814
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemia-reperfusion in mice.

  2006cited by this paper
• Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level.

  2005cited by this paper
• Ischemia-induced norepinephrine release, but not norepinephrine-derived free radicals, contributes to myocardial ischemia-reperfusion injury.

  2005cited by this paper
• Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement‐mediated acute inflammation

  2004cited by this paper
• Optimal Windows of Statin Use for Immediate Infarct Limitation: 5′-Nucleotidase as Another Downstream Molecule of Phosphatidylinositol 3-Kinase

  2004cited by this paper
• Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway.

  2003cited by this paper
• Simvastatin Normalizes Autonomic Neural Control in Experimental Heart Failure

  2003cited by this paper
• Reduction of myocardial infarct size by fluvastatin.

  2003cited by this paper
• Acute Reduction of Myocardial Infarct Size By a Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor Is Mediated by Endothelial Nitric Oxide Synthase

  2003cited by this paper
• Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment

  2003cited by this paper
• Antioxidative potential of fluvastatin via the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.

  2003cited by this paper
• N-terminal pro-BNP as a biochemical marker for assessing severity of aortic stenosis

  2003cited by this paper
• Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor.

  2002cited by this paper
• Increased Nitric Oxide Bioavailability in Endothelial Cells Contributes to the Pleiotropic Effect of Cerivastatin

  2002cited by this paper
• Patients on lipid-lowering therapy at the time of a myocardial infarction have smaller infarcts: further evidence to suggest a salutary effect in acute coronary syndromes

  2002cited by this paper
• Fluvastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction

  2002cited by this paper
• Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: an ex vivo study in isolated working rat hearts.

  2001cited by this paper
• Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload.

  2001cited by this paper
• Pretreatment With Simvastatin Attenuates Myocardial Dysfunction After Ischemia and Chronic Reperfusion

  2001cited by this paper
• Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.

  2001cited by this paper
• HMG‐CoA reductase inhibition protects the diabetic myocardium from ischemia‐reperfusion injury

  2001cited by this paper
• ERRATA

  2001cited by this paper
• Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin.

  2001cited by this paper
• The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

  2000cited by this paper
• Mechanism of antioxidative activity of fluvastatin-determination of the active position.

  2000cited by this paper
• Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.

  2000cited by this paper
• Statins and C-reactive protein.

  1999cited by this paper
• Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts.

  1999cited by this paper
• Opening of mitochondrial KATPchannel induces early and delayed cardioprotective effect: role of nitric oxide.

  1999cited by this paper
• Statins and C-reactive protein.

  1999cited by this paper
• Reactive oxygen species‐induced molecular damage and its application in pathology

  1999cited by this paper
• An in vitro study of the hydroxyl radical scavenging property of fluvastatin, and HMG-CoA reductase inhibitor.

  1999cited by this paper
• A986S polymorphism of calcium-sensing receptor.

  1999cited by this paper
• Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8-hydroxydeoxyguanosine formation.

  1998cited by this paper
• Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase*

  1998cited by this paper
• The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats.

  1994cited by this paper
• Does reperfusion injury exist in humans?

  1993cited by this paper
• Dimethylthiourea, but not dimethylsulfoxide, reduces canine myocardial infarct size.

  1989cited by this paper
• Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2.ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

  1988cited by this paper
• Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

  1988cited by this paper
• Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction

  1987cited by this paper
• Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.

  1984cited by this paper
• Canine Myocardial Reperfusion Injury: Its Reduction by the Combined Administration of Superoxide Dismutase and Catalase

  1984cited by this paper

• Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway

  2021cites this paper
• Polymers and Nanoparticles for Statin Delivery: Current Use and Future Perspectives in Cardiovascular Disease

  2021cites this paper
• Cellular and molecular approaches to enhance myocardial recovery after myocardial infarction.

  2019cites this paper
• Effects of Intensive Statin Therapy on Left Ventricular Function in Patients with Myocardial Infarction and Abnormal Glucose Tolerance

  2017cites this paper
• A review of strategies for infarct size reduction during acute myocardial infarction.

  2017cites this paper
• Pleiotropic Effects of Simvastatin on Some Calcium Regulatory and Myofibrillar Proteins in Ischemic/Reperfused Heart: Causality of Statins Cardioprotection?

  2016cites this paper
• A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model

  2015influential citation
• Fluvastatin-induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature

  2014cites this paper
• Fluvastatin inhibits the induction of inducible nitric oxide synthase, an inflammatory biomarker, in hepatocytes

  2013cites this paper
• HMGB1 and its physiological and pathological roles.

  2012cites this paper
• The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations

  2012cites this paper
• Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway

  2012cites this paper
• Myocardial Reperfusion Injury: Reactive Oxygen Species vs. NHE-1 Reactivation

  2011cites this paper
• The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4

  2011cites this paper
• Inflammation and Genetics of Inflammation in Cardiovascular Diseases

  2011cites this paper
• Targeting the reperfusion injury salvage kinase pathway in the clinical setting

  2011cites this paper
• Pleiotropic effects of statins. - Basic research and clinical perspectives -.

  2010cites this paper
• Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway.

  2010cites this paper
• Effect of atorvastatin on expression of IL-10 and TNF-alpha mRNA in myocardial ischemia-reperfusion injury in rats.

  2009cites this paper
• Effects of pretreatment with statins on infarct size in patients with acute myocardial infarction who receive fibrinolytic therapy.

  2009cites this paper
• Simvastatin reduces myocardial infarct size via increased nitric oxide production in normocholesterolemic rabbits.

  2009cites this paper
• Statins and cardioprotection--more than just lipid lowering?

  2009cites this paper
• Inhibitory kappa B kinase-beta is a target for specific nuclear factor kappa B-mediated delayed cardioprotection.

  2008cites this paper
• Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat.

  2008cites this paper
• Acute protective effects of different doses of simvastatin in the rat model of renal ischemia-reperfusion injury.

  2008cites this paper
• Effects of HMGB1 on ischemia-reperfusion injury in the rat heart.

  2008cites this paper
• Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model.

  2008cites this paper
• Potential therapeutic role of statins in neurological disorders

  2008cites this paper
• Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stressin amyloid β injection mouse model

  2008cites this paper
• Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits.

  2007cites this paper
• Inhibitory kappa B kinase-b is a target for specific nuclear factor kappa B-mediated delayed cardioprotection

  year unknowncites this paper