Role of the antioxidant ascorbate in hibernation and warming from hibernation.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

• Publication date

  2002-12-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/S1532-0456(02)00118-7PMID 12458177
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ascorbic acid and focal cerebral ischaemia in a primate model

  2005cited by this paper
• Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.

  2002cited by this paper
• Xanthine Oxidase in Biology and Medicine

  2002cited by this paper
• The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis.

  2001cited by this paper
• Age-related responses of the microcirculation to ischemia-reperfusion and inflammation.

  2001cited by this paper
• Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins

  2001cited by this paper
• Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain

  2001cited by this paper
• Hibernation, a model of neuroprotection.

  2001cited by this paper
• Ascorbate dynamics and oxygen consumption during arousal from hibernation in Arctic ground squirrels.

  2001cited by this paper
• Novel Ca2+ Dependence and Time Course of Somatodendritic Dopamine Release: Substantia Nigra versus Striatum

  2001cited by this paper
• Neuroprotective adaptations in hibernation: therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases.

  2001cited by this paper
• Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise.

  2001cited by this paper
• Ascorbate regulation and its neuroprotective role in the brain.

  2000cited by this paper
• Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke.

  2000cited by this paper
• Neuroprotection by 2-h postischemia administration of two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia.

  2000cited by this paper
• A family of mammalian Na+-dependent L-ascorbic acid transporters

  1999cited by this paper
• MOLECULAR AND METABOLIC ASPECTS OF MAMMALIAN HIBERNATION

  1999cited by this paper
• Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels.

  1999cited by this paper
• Diet and Oxidative Stress: A Novel Synthesis of Epidemiological Data on Alzheimer's Disease

  1999cited by this paper
• Ascorbate and glutathione regulation in hibernating ground squirrels.

  1999cited by this paper
• Ascorbate modulates glutamate-induced excitations of striatal neurons.

  1998cited by this paper
• Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies.

  1998cited by this paper
• Hibernation in Ground Squirrels Induces State and Species-Specific Tolerance to Hypoxia and Aglycemia: An In Vitro Study in Hippocampal Slices

  1998cited by this paper
• Effect of Ascorbic Acid on Infarct Size in Experimental Focal Cerebral Ischaemia and Reperfusion in a Primate Model

  1998cited by this paper
• Differential compartmentalization of brain ascorbate and glutathione between neurons and glia.

  1997cited by this paper
• A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

  1997cited by this paper
• Antioxidants, mitochondrial hyperoxidation and electrical recovery after anoxia in hippocampal slices.

  1997cited by this paper
• Prolonged oxidative stress on actin.

  1997cited by this paper
• N-acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats.

  1995cited by this paper
• High Levels of Ascorbic Acid, Not Glutathione, in the CNS of Anoxia‐Tolerant Reptiles Contrasted with Levels in Anoxia‐Intolerant Species

  1995cited by this paper
• Enzymatic/Nonenzymatic Sources of Oxyradicals and Regulation of Antioxidant Defenses a

  1994cited by this paper
• Thermal effects on neuronal activity in suprachiasmatic nuclei of hibernators and nonhibernators.

  1994cited by this paper
• Local Cerebral Blood Flow during Hibernation, a Model of Natural Tolerance to “Cerebral Ischemia”

  1994cited by this paper
• A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission.

  1994cited by this paper
• Ischemia/reperfusion-induced injury of forebrain mitochondria and protection by ascorbate.

  1993cited by this paper
• Ascorbic acid in the brain.

  1993cited by this paper
• Repeated changes of dendritic morphology in the hippocampus of ground squirrels in the course of hibernation.

  1992cited by this paper
• A pilot trial of high‐dose alpha‐tocopherol and ascorbate in early Parkinson's disease

  1992cited by this paper
• Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons.

  1992cited by this paper
• Selective vulnerability of the hippocampus in brain ischemia.

  1991cited by this paper
• Beta-hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus.

  1990cited by this paper
• Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate.

  1990cited by this paper
• Ascorbic Acid Transport and Accumulation Into Human Neutrophils a

  1990cited by this paper
• Ascorbate is an outstanding antioxidant in human blood plasma.

  1989cited by this paper
• Freeze avoidance in a mammal: body temperatures below 0 degree C in an Arctic hibernator.

  1989cited by this paper
• Ascorbic acid transport and accumulation in human neutrophils.

  1989cited by this paper
• Interaction of Ascorbate and α‐Tocopherol

  1987cited by this paper
• Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

  1987cited by this paper
• Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?

  1987cited by this paper
• Interaction of ascorbate and alpha-tocopherol.

  1987cited by this paper
• SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS *

  1975cited by this paper
• Several blood and circulatory changes in the hibernation of the 13-lined ground squirrel, Citellus tridecemlineatus.

  1973cited by this paper
• The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.

  1973cited by this paper
• Seasonal variations of the immune response of ground squirrels kept at 22-24 degrees C.

  1972cited by this paper
• Blood clotting defect in hibernating ground squirrels (Citellus tridecemlineatus).

  1963cited by this paper
• Relation of Prothrombin to the Prolongation of Clotting Time in Aestivating Ground Squirrels.

  1952cited by this paper
• Prolongation of clotting time in dormant estivating mammals.

  1951cited by this paper

• Exogenous LEA proteins expression enhances cold tolerance in mammalian cells by reducing oxidative stress

  2025cites this paper
• Molecular Mechanisms of DNA Damage Response and Epigenetic Regulation in Cold-Adapted Species: Implications for Genome Stability and Molecular Network Perspective

  2025cites this paper
• Neuroplasticity and brain health: insights from natural torpor

  2025cites this paper
• Oxidative stress levels and antioxidant defense mechanisms (Nrf2-Keap1 signaling pathway) in the Harderian glands of hibernating Daurian ground squirrels.

  2024cites this paper
• Cold resistance of mammalian hibernators ∼ a matter of ferroptosis?

  2024cites this paper
• Effects of Hibernation on Colonic Epithelial Tissue and Gut Microbiota in Wild Chipmunks (Tamias sibiricus)

  2024cites this paper
• Understanding seasonal telomere length dynamics in hibernating species.

  2024cites this paper
• Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor–Arousal Cycle of Ground Squirrels

  2024cites this paper
• Torpid 13-lined ground squirrel liver mitochondria resist anoxia-reoxygenation despite high levels of protein damage

  2023cites this paper
• Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance

  2023cites this paper
• Integrated Redox-Metabolic Orchestration Sustains Life in Hibernating Ground Squirrels

  2023cites this paper
• Temperature Effects on DNA Damage during Hibernation

  2022cites this paper
• Modulating Nrf2 transcription factor activity: Revealing the regulatory mechanisms of antioxidant defenses during hibernation in 13-lined ground squirrels.

  2021cites this paper
• Reactive oxygen species damage and consequences for mitochondrial function in the hibernating thirteen-lined ground squirrel, Ictidomys tridecemlineatus

  2020influential citation
• Human torpor: translating insights from nature into manned deep space expedition

  2020cites this paper
• Expression of Paracrine Effectors in Human Adipose‐Derived Mesenchymal Stem Cells Treated With Plasma From Brown Bears (Ursus arctos)

  2020cites this paper
• Proteome and phosphoproteome profiling reveals the regulation mechanism of hibernation in a freshwater leech (Whitmania pigra).

  2020cites this paper
• Oxidative stress markers and antioxidant defense in hibernating common Asian toads, Duttaphrynus melanostictus

  2020cites this paper
• Physiological responses in vitamin C system during hibernation in juvenile Chinese soft-shelled turtle Pelodiscus sinensis

  2018cites this paper
• Free Amino Acid Profile in Blood Plasma of Bats (Myotis dasycneme Boie, 1825) Exposed to Low Positive and Near-Zero Temperatures

  2018cites this paper
• Renal Mitochondrial Response to Low Temperature in Non-Hibernating and Hibernating Species

  2017cites this paper
• Enhanced oxidative capacity of ground squirrel brain mitochondria during hibernation.

  2017cites this paper
• University of Groningen The role of endogenous H 2 S production during hibernation and forced hypothermia

  2017cites this paper
• Regulation of blood oxygen transport in hibernating mammals

  2017cites this paper
• Exploring principles of hibernation for organ preservation.

  2016cites this paper
• Antioxidant Defenses in the Brains of Bats during Hibernation

  2016cites this paper
• Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death.

  2016cites this paper
• Recent Advances in Analytical Methodology for in vivo Electrochemistry in Mammals

  2016cites this paper
• The role of endogenous H2S production during hibernation and forced hypothermia: towards safe cooling and rewarming in clinical practice

  2015cites this paper
• Developmental study of vitamin C distribution in children's brainstems by immunohistochemistry.

  2015cites this paper
• Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel

  2015cites this paper
• Proteomics approaches shed new light on hibernation physiology

  2015cites this paper
• Free Radical Biology in Hypothermia

  2014cites this paper
• Somatic Signature of Brain-Specific Single Nucleotide Variations in Sporadic Alzheimer's Disease

  2014cites this paper
• The effects of hibernation on the contractile and biochemical properties of skeletal muscles in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus

  2013cites this paper
• SUMO and Ischemic Tolerance

  2013cites this paper
• Cytoskeletal Regulation Dominates Temperature-Sensitive Proteomic Changes of Hibernation in Forebrain of 13-Lined Ground Squirrels

  2013cites this paper
• Renal adaptation during hibernation.

  2013cites this paper
• Role of redox metabolism for adaptation of aquatic animals to drastic changes in oxygen availability.

  2013cites this paper
• Metabolic Changes in Summer Active and Anuric Hibernating Free-Ranging Brown Bears (Ursus arctos)

  2013cites this paper
• Seasonal and Regional Differences in Gene Expression in the Brain of a Hibernating Mammal

  2013cites this paper
• Tolerance Against Global Cerebral Ischemia: Experimental Strategies, Mechanisms, and Clinical Applications

  2013cites this paper
• Tissue Engineered Conjunctival Epithelial Transplants For The Treatment Of Ocular Surface Disorders

  2013cites this paper
• Neuroprotection: lessons from hibernators.

  2012cites this paper
• Aestivation: signaling and hypometabolism

  2012cites this paper
• Expression of NF‐κB and downstream antioxidant genes in skeletal muscle of hibernating ground squirrels, Spermophilus tridecemlineatus

  2012cites this paper
• Antioxidant and prooxidant effects of ascorbate during iron-induced carbonyl formation in serum albumin

  2012cites this paper
• Metabolic cycles in a circannual hibernator.

  2011cites this paper
• Relationship among Plasma Homocysteine, Folate, Vitamin B12 and Nutrient Intake and Neurocognitive Function in the Elderly

  2011cites this paper
• Technology Development for Physiological Genomics Metabolic cycles in a circannual

  2011cites this paper
• Multistate proteomics analysis reveals novel strategies used by a hibernator to precondition the heart and conserve ATP for winter heterothermy.

  2011cites this paper
• Mammalian Hibernation: Physiology, Cell Signaling, and Gene Controls on Metabolic Rate Depression

  2010cites this paper
• Physiological implications of natural versus induced arousal from torpor

  2010cites this paper
• Metabolic rate depression: the biochemistry of mammalian hibernation.

  2010cites this paper
• Heme oxygenase expression and Nrf2 signaling during hibernation in ground squirrels.

  2010influential citation
• Regulation of Akt during torpor in the hibernating ground squirrel, Ictidomys tridecemlineatus

  2010cites this paper
• Dietary palmitate and linoleate oxidations, oxidative stress, and DNA damage differ according to season in mouse lemurs exposed to a chronic food deprivation.

  2009cites this paper
• Out Cold: Biochemical Regulation of Mammalian Hibernation – A Mini-Review

  2009cites this paper
• Metabolic function in Drosophila melanogaster in response to hypoxia and pure oxygen

  2009cites this paper
• Ascorbic Acid and Rates of Cognitive Decline in Alzheimer's Disease

  2009cites this paper
• Physiological oxidative stress after arousal from hibernation in Arctic ground squirrel.

  2009cites this paper
• Ischemic tolerance as an active and intrinsic neuroprotective mechanism.

  2009cites this paper
• Increase in the contribution of transamination to the respiration of mitochondria during arousal.

  2008cites this paper
• Coping with the stress: expression of ATF4, ATF6, and downstream targets in organs of hibernating ground squirrels.

  2008cites this paper
• Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus

  2008cites this paper
• Protein SUMOylation is Massively Increased in Hibernation Torpor and is Critical for the Cytoprotection Provided by Ischemic Preconditioning and Hypothermia in SHSY5Y Cells

  2007cites this paper
• Selected oxidative stress markers in a South American crocodilian species.

  2007cites this paper
• Cytosolic phospholipase A2 regulation in the hibernating thirteen-lined ground squirrel

  2007cites this paper
• Tribute to P. L. Lutz: putting life on `pause' – molecular regulation of hypometabolism

  2007influential citation
• Antioxidant defense in hibernation: cloning and expression of peroxiredoxins from hibernating ground squirrels, Spermophilus tridecemlineatus.

  2007cites this paper
• Implications of dealing with airborne substances and reactive oxygen species: what mammalian lungs, animals, and plants have to say?

  2007cites this paper
• Enhanced antioxidant defense due to extracellular catalase activity in Syrian hamster during arousal from hibernation.

  2006cites this paper
• Potential for discovery of neuroprotective factors in serum and tissue from hibernating species.

  2006cites this paper
• Torpeur et hibernation chez les vertèbrés homéothermes

  2006cites this paper
• The arterial chemoreceptors

  2006cites this paper
• Changes in antioxidant protein SP-22 of chipmunk carotid bodies during the hibernation season.

  2006cites this paper
• Up-regulation of the endoplasmic reticulum molecular chaperone GRP78 during hibernation in thirteen-lined ground squirrels

  2006cites this paper
• Vitamin E Ameliorates Some Biochemical Parameters in Normal and Diabetic Rats

  2006cites this paper
• Temperature, Hematocrit, pH, and Glucose 4-Way ANOVA of Cytochrome C Oxidase Redox Status During Systemic Cold Circulatory Arrest in Swine

  2005cites this paper
• Annual lipid cycles in hibernators: integration of physiology and behavior.

  2005cites this paper
• Up-regulation of a thioredoxin peroxidase-like protein, proliferation-associated gene, in hibernating bats.

  2005cites this paper
• Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production

  2005cites this paper
• Brain, spine, and muscle cytochrome Cu-A redox patterns of change during hypothermic circulatory arrest in swine.

  2005cites this paper
• Regulated hypothermia reduces brain oxidative stress after hypoxic-ischemia.

  2004cites this paper
• Animal response to drastic changes in oxygen availability and physiological oxidative stress.

  2002cites this paper
• Brain antioxidant regulation in mammals and anoxia-tolerant reptiles: balanced for neuroprotection and neuromodulation.

  2002cites this paper