Intracellular traffic of the K+ channels TASK‐1 and TASK‐3: role of N‐ and C‐terminal sorting signals and interaction with 14‐3‐3 proteins

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Physiology

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2008.164756PMID 19139046PMCID PMC2673767
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation-dependent Binding of 14-3-3 Proteins Controls TRESK Regulation*

  2008influential reference
• Localization and targeting of voltage-dependent ion channels in mammalian central neurons.

  2008cited by this paper
• Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact.

  2008cited by this paper
• TASK channel deletion in mice causes primary hyperaldosteronism

  2008cited by this paper
• Forward Transport of K2P3.1: Mediation by 14‐3‐3 and COPI, Modulation by p11

  2008influential reference
• Mtap2 Is a Constituent of the Protein Network That Regulates Twik-Related K+ Channel Expression and Trafficking

  2008cited by this paper
• Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

  2008cited by this paper
• Direct Interaction of Endogenous Kv Channels with Syntaxin Enhances Exocytosis by Neuroendocrine Cells

  2008cited by this paper
• A Di‐Acidic Sequence Motif Enhances the Surface Expression of the Potassium Channel TASK‐3

  2007cited by this paper
• Novel cargo-binding site in the β and δ subunits of coatomer

  2007cited by this paper
• Bidirectional Modulation of Transmitter Release by Calcium Channel/Syntaxin Interactions In Vivo

  2007cited by this paper
• The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.

  2007cited by this paper
• TASK-3 Two-Pore Domain Potassium Channels Enable Sustained High-Frequency Firing in Cerebellar Granule Neurons

  2007cited by this paper
• Up-regulated astroglial TWIK-related acid-sensitive K+ channel-1 (TASK-1) in the hippocampus of seizure-sensitive gerbils: a target of anti-epileptic drugs.

  2007cited by this paper
• TASK-3 Knockout Mice Exhibit Exaggerated Nocturnal Activity, Impairments in Cognitive Functions, and Reduced Sensitivity to Inhalation Anesthetics

  2007cited by this paper
• Neuronal two‐pore‐domain potassium channels and their regulation by G protein‐coupled receptors

  2007cited by this paper
• S100A10/p11: family, friends and functions

  2007cited by this paper
• Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus.

  2007cited by this paper
• TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity

  2007cited by this paper
• TASK-like potassium channels and oxygen sensing in the carotid body.

  2007cited by this paper
• The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.

  2006cited by this paper
• 14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5

  2006cited by this paper
• Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins.

  2006influential reference
• A Multimeric Membrane Protein Reveals 14‐3‐3 Isoform Specificity in Forward Transport in Yeast

  2006cited by this paper
• Membrane Potential-regulated Transcription of the Resting K+ Conductance TASK-3 via the Calcineurin Pathway*

  2006cited by this paper
• Impact of TASK-1 in Human Pulmonary Artery Smooth Muscle Cells

  2006cited by this paper
• Selective Export of HLA-F by Its Cytoplasmic Tail1

  2006influential reference
• Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels

  2006cited by this paper
• Expression of TWIK-related acid sensitive K+ channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia.

  2006cited by this paper
• The Retention Factor p11 Confers an Endoplasmic Reticulum‐Localization Signal to the Potassium Channel TASK‐1

  2006cited by this paper
• 14-3-3 proteins: a historic overview.

  2006cited by this paper
• Voltage-Gated Potassium Channels: Regulation by Accessory Subunits

  2006cited by this paper
• The background K(+) channel TASK-3 is regulated at both the transcriptional and post-transcriptional levels.

  2006cited by this paper
• 14-3-3 proteins in membrane protein transport

  2006cited by this paper
• Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways.

  2006cited by this paper
• Regulation of Sodium and Calcium Channels by Signaling Complexes

  2006cited by this paper
• C-terminal Recognition by 14-3-3 Proteins for Surface Expression of Membrane Receptors*

  2005cited by this paper
• Hide and run

  2005cited by this paper
• Genetic isolation of transport signals directing cell surface expression

  2005influential reference
• Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

  2004influential reference
• A Specific Endoplasmic Reticulum Export Signal Drives Transport of Stem Cell Factor (Kitl) to the Cell Surface*

  2004influential reference
• Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell.

  2004cited by this paper
• The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs.

  2004cited by this paper
• ARF6‐dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6

  2004cited by this paper
• Unlocking the code of 14-3-3

  2004cited by this paper
• Contribution of TWIK-Related Acid-Sensitive K+ Channel 1 (TASK1) and TASK3 Channels to the Control of Activity Modes in Thalamocortical Neurons

  2003influential reference
• 14-3-3 dimers probe the assembly status of multimeric membrane proteins.

  2003cited by this paper
• The α- and β′-COP WD40 Domains Mediate Cargo-selective Interactions with Distinct Di-lysine Motifs

  2003cited by this paper
• 2P domain K+ channels: novel pharmacological targets for volatile general anesthetics.

  2003cited by this paper
• Interaction with 14‐3‐3 proteins promotes functional expression of the potassium channels TASK‐1 and TASK‐3

  2002cited by this paper
• p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK‐1

  2002influential reference
• Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.

  2002influential reference
• Role of cytoplasmic C-terminal amino acids of membrane proteins in ER export.

  2002influential reference
• 14‐3‐3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

  2002cited by this paper
• TASK-3 dominates the background potassium conductance in rat adrenal glomerulosa cells.

  2002cited by this paper
• Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.

  2001influential reference
• Block of Kcnk3 by Protons

  2001cited by this paper
• TASK-3, a Novel Tandem Pore Domain Acid-sensitive K+Channel

  2000influential reference
• TASK-3, a New Member of the Tandem Pore K+ Channel Family*

  2000cited by this paper
• Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3*

  2000cited by this paper
• A trafficking checkpoint controls GABA(B) receptor heterodimerization.

  2000cited by this paper
• A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.

  1999cited by this paper
• GRASP65, a protein involved in the stacking of Golgi cisternae.

  1997cited by this paper
• TASK, a human background K+ channel to sense external pH variations near physiological pH

  1997influential reference
• An N‐terminal double‐arginine motif maintains type II membrane proteins in the endoplasmic reticulum.

  1994influential reference
• Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

  1990cited by this paper
• Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum.

  1989influential reference

• Structure-Function Relationships of K2P Channels.

  2026cites this paper
• Two-pore domain potassium channels (K2P) in GtoPdb v.2025.3

  2025cites this paper
• Two-pore domain potassium channels (K2P) in GtoPdb v.2025.4

  2025cites this paper
• SERTM2: a neuroactive player in the world of micropeptides

  2025cites this paper
• Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence

  2024cites this paper
• Two-pore domain potassium channels (K2P) in GtoPdb v.2023.1

  2023cites this paper
• β-COP Suppresses the Surface Expression of the TREK2

  2023cites this paper
• The cellular pathways that maintain the quality control and transport of diverse potassium channels.

  2023cites this paper
• β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes

  2022cites this paper
• Anti-hypoxic effect of interleukin-10 in hippocampal neurons is mediated by modulation of TASK-1 and TASK-3 channels activity.

  2022cites this paper
• 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons

  2021cites this paper
• Identification of a unique endoplasmic retention motif in the Xenopus GIRK5 channel and its contribution to oocyte maturation

  2021cites this paper
• Physiological roles of heteromerization: focus on the two‐pore domain potassium channels

  2020cites this paper
• 14-3-3 gamma, a novel regulator of the large-conductance Ca2+-activated K+ channels.

  2020cites this paper
• A lower X-gate in TASK channels traps inhibitors within the vestibule

  2020cites this paper
• TASK channels: channelopathies, trafficking, and receptor-mediated inhibition

  2020cites this paper
• A unique lower X-gate in TASK channels traps inhibitors within the vestibule

  2019cites this paper
• KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.

  2019cites this paper
• Surface expression of TTYH2 is attenuated by direct interaction with β-COP

  2019cites this paper
• The Potassium Channel Odyssey: Mechanisms of Traffic and Membrane Arrangement

  2019cites this paper
• Trafficking and Quality Control of Inward-Rectifying Potassium Channels in the Model Eukaryote Saccharomyces cerevisiae

  2018cites this paper
• Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox

  2018cites this paper
• A light-gated potassium channel for sustained neuronal inhibition

  2018cites this paper
• Functional properties and pharmacological regulation of two-pore domain potassium channels associated with pulmonary disorders

  2018cites this paper
• KCC2 regulates neuronal excitability and hippocampal activity via interaction with Task-3 channels

  2018cites this paper
• TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications

  2017cites this paper
• 14‐3‐3 Proteins regulate K2P5.1 surface expression on T lymphocytes

  2017cites this paper
• Stress-Kinase Regulation of TASK-1 and TASK-3

  2017cites this paper
• Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems

  2017cites this paper
• δ-COP contains a helix C-terminal to its longin domain key to COPI dynamics and function

  2016cites this paper
• A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1

  2016influential citation
• Principal component analysis based unsupervised feature extraction applied to publicly available gene expression profiles provides new insights into the mechanisms of action of histone deacetylase inhibitors

  2016cites this paper
• Stabilization of protein-protein interaction complexes through small molecules.

  2016cites this paper
• Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop.

  2016cites this paper
• An extracellular drug binding site of the potassium channels THIK-1 and THIK-2

  2015cites this paper
• Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2

  2015cites this paper
• The role of protein–protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3

  2015cites this paper
• Much more than a leak: structure and function of K2P-channels

  2015cites this paper
• The family of K2P channels: salient structural and functional properties

  2015cites this paper
• Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum

  2015cites this paper
• Handbook of ion channels

  2015cites this paper
• K2P channels in plants and animals

  2015cites this paper
• ION CHANNELS, PROTEIN KINASE C AND CAVEOLAE IN CARDIOPROTECTION

  2015cites this paper
• Two-Pore Domain Potassium Channels

  2015cites this paper
• A Novel Channelopathy in Pulmonary Arterial Hypertension

  2014cites this paper
• Endocytosis as a mode to regulate functional expression of two-pore domain potassium (K2P) channels

  2014cites this paper
• Studies on Migration-inhibition Activity of a 3 , 12-Unsubsituted Fusicoccin Derivative

  2014cites this paper
• A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels

  2014cites this paper
• Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes

  2014cites this paper
• Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2

  2014cites this paper
• Role of K2P channels in stimulus-secretion coupling

  2014cites this paper
• Controlling insulin secretion: an exciting TASK.

  2014cites this paper
• Tubulin Binds to the Cytoplasmic Loop of TRESK Background K+ Channel In Vitro

  2014cites this paper
• [Differentially expressed genes identified in the main olfactory epithelium of mice with deficiency of adenylate cyclase 3 by using suppression subtractive hybridization approach].

  2014cites this paper
• A 14‐3‐3 Mode‐1 Binding Motif Initiates Gap Junction Internalization During Acute Cardiac Ischemia

  2014cites this paper
• Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1

  2014cites this paper
• The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C.

  2013cites this paper
• Regulation of potassium channel trafficking in the distal nephron

  2013cites this paper
• A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.

  2013influential citation
• Chromothripsis in uterine leiomyomas.

  2013cites this paper
• A novel channelopathy in pulmonary arterial hypertension.

  2013cites this paper
• Role of the immunoglobulin superfamily member Basigin in sensory neuron dendrite morphogenesis in Drosophila

  2013cites this paper
• Regulation of subcellular localization of lipid phosphatase SAC1

  2013cites this paper
• Dynamic Regulation at the Neuronal Plasma Membrane: Novel Endocytic Mechanisms Control Anesthetic-Activated Potassium Channels and Amphetamine-Sensitive Dopamine Transporters: A Dissertation

  2013cites this paper
• Silencing of the Tandem Pore Domain Halothane-inhibited K+ Channel 2 (THIK2) Relies on Combined Intracellular Retention and Low Intrinsic Activity at the Plasma Membrane*

  2013cites this paper
• Chromothripsis in Uterine Leiomyomas

  2013cites this paper
• Snorkel: An Epitope Tagging System for Measuring the Surface Expression of Membrane Proteins

  2013cites this paper
• L-Type Calcium Channels Play a Critical Role in Maintaining Lens Transparency by Regulating Phosphorylation of Aquaporin-0 and Myosin Light Chain and Expression of Connexins

  2013cites this paper
• A novel channelopathy in pulmonary arterial hypertension.

  2013cites this paper
• A Role for K2P Channels in the Operation of Somatosensory Nociceptors

  2012cites this paper
• On the mechanism of TASK channel inhibition by G-Protein coupled receptors

  2012cites this paper
• What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart

  2012cites this paper
• Interaction of Voltage-gated Sodium Channel Nav1.6 (SCN8A) with Microtubule-associated Protein Map1b*

  2012cites this paper
• The Acid-sensitive, Anesthetic-activated Potassium Leak Channel, KCNK3, Is Regulated by 14-3-3β-dependent, Protein Kinase C (PKC)-mediated Endocytic Trafficking*

  2012cites this paper
• 14-3-3ζ Protein Regulates Anterograde Transport of the Human κ-Opioid Receptor (hKOPR)*

  2012cites this paper
• Protein Kinase A Is Central for Forward Transport of Two-pore Domain Potassium Channels K2P3.1 and K2P9.1*

  2011cites this paper
• 14-3-3 proteins in neurodegeneration.

  2011cites this paper
• Presence of task-1 channel in the laryngeal mucosa in the newborn lamb

  2011cites this paper
• Molecular regulations governing TREK and TRAAK channel functions

  2011cites this paper
• Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport.

  2011influential citation
• Trafficking motifs in potassium channels

  2010cites this paper
• Trafficking of Neuronal Two Pore Domain Potassium Channels

  2010influential citation
• Phosphorylation-dependent C-terminal Binding of 14-3-3 Proteins Promotes Cell Surface Expression of HIV Co-receptor GPR15*

  2010cites this paper
• Dominant Negative Effects of a Non-conducting TREK1 Splice Variant Expressed in Brain*

  2010cites this paper
• A comparison of the pore-forming subunits of the ATP-sensitive potassium channel

  2010cites this paper
• KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating

  2009cites this paper
• PI3K/Akt signalling‐mediated protein surface expression sensed by 14‐3‐3 interacting motif

  2009cites this paper