Leptomeningeal metastases: current concepts and management guidelines.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  The Journal of the National Comprehensive Cancer Network

• Publication date

  2005-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.6004/JNCCN.2005.0039PMID 16194457
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology.

  2005cited by this paper
• Intrathecal mafosfamide: a preclinical pharmacology and phase I trial.

  2005influential reference
• Comparative spine imaging in leptomeningeal metastases

  2005cited by this paper
• Central nervous system pharmacokinetics of high-dose cytosine arabinoside

  2005cited by this paper
• Treatment of leptomeningeal carcinomatosis from breast cancer with systemically administered chemotherapy.

  2004cited by this paper
• Intrathecal cytosine arabinoside for the treatment of meningeal metastases from malignant brain tumors and systemic tumors

  2004cited by this paper
• Initial chemotherapy in gliomatosis cerebri

  2004cited by this paper
• The relevance of intraventricular chemotherapy for leptomeningeal metastasis in breast cancer: a randomised study.

  2004cited by this paper
• Intraventricular treatment of relapsed central nervous system lymphoma with the anti-CD20 antibody rituximab.

  2004cited by this paper
• Intrathecal administration of topotecan in nonhuman primates

  2004cited by this paper
• Phase I trial of intrathecal liposomal cytarabine in children with neoplastic meningitis.

  2004cited by this paper
• Response of Neoplastic Meningitis from Solid Tumors to Oral Capecitabine

  2003cited by this paper
• Combined-modality Treatment of Leptomeningeal Gliomatosis

  2003cited by this paper
• Neurologic Complications of Cancer

  2003cited by this paper
• Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone.

  2003cited by this paper
• Feasibility of Long-Term Intraventricular Therapy with Mafosfamide (n = 26) and Etoposide (n = 11): Experience in 26 Children With Disseminated Malignant Brain Tumors

  2003influential reference
• Quality‐of‐life–adjusted survival comparison of sustained‐release cytosine arabinoside versus intrathecal methotrexate for treatment of solid tumor neoplastic meningitis

  2003cited by this paper
• A Phase II trial of intra‐cerebrospinal fluid alpha interferon in the treatment of neoplastic meningitis

  2002cited by this paper
• Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease

  2002cited by this paper
• Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine

  2001cited by this paper
• A comparison between ventricular and lumbar cerebrospinal fluid cytology in adult patients with leptomeningeal metastases.

  2001cited by this paper
• Molecular detection of metastatic melanoma cells in cerebrospinal fluid in melanoma patients.

  2001cited by this paper
• PET in neuro-oncology

  2001cited by this paper
• Lipid‐associated sialoprotein in the cerebrospinal fluid

  2001cited by this paper
• Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism.

  2001cited by this paper
• Cerebrospinal fluid gastrin releasing peptide in the diagnosis of leptomeningeal metastases from small cell carcinoma

  2001cited by this paper
• Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patients with malignant germ cell tumor can be used to detect early recurrence and monitor the response to treatment.

  2000cited by this paper
• Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity

  2000cited by this paper
• Carcinomatous meningitis and solid tumours.

  2000cited by this paper
• Diagnosing lymphoproliferative disorders involving the cerebrospinal fluid: Increased sensitivity using flow cytometric analysis

  2000cited by this paper
• Treatment of leptomeningeal metastases evaluated by interphase cytogenetics.

  2000cited by this paper
• Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis

  2000cited by this paper
• Leptomeningeal carcinomatosis.

  1999influential reference
• NCCN clinical practice guidelines for carcinomatous/lymphomatous meningitis

  1999cited by this paper
• A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors.

  1999cited by this paper
• Intraventricular concentration times time (C × T) methotrexate and cytarabine for patients with recurrent meningeal leukemia and lymphoma

  1999cited by this paper
• The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis

  1999cited by this paper
• Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis

  1998cited by this paper
• Cerebrospinal fluid cytology in patients with cancer

  1998influential reference
• Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia.

  1998cited by this paper
• Cytologically negative carcinomatous meningitis: Usefulness of CSF biochemical markers

  1998cited by this paper
• High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary?

  1998influential reference
• Treatment of neoplastic meningitis by targeted radiation using 131I-radiolabelled monoclonal antibodies

  1998cited by this paper
• Treatment of neoplastic meningitis by targeted radiation using (131)I-radiolabelled monoclonal antibodies. Results of responses and long term follow-up in 40 patients.

  1998cited by this paper
• Diagnosis and outcome measures in trials for neoplastic meningitis: a review of the literature and clinical experience.

  1998cited by this paper
• Current diagnosis and treatment of leptomeningeal metastasis

  1998cited by this paper
• Enhanced detection of malignant lymphoma in cerebrospinal fluid by multiparameter flow cytometry.

  1998cited by this paper
• Neoplastic meningitis following surgical resection of isolated cerebellar metastasis: A potentially preventable complication

  1997influential reference
• Prognostic significance of coexistent bulky metastatic central nervous system disease in patients with leptomeningeal metastases.

  1997cited by this paper
• Treatment of leptomeningeal metastases in a rat model using a recombinant adenovirus containing the HSV-tk gene.

  1996cited by this paper
• Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial results.

  1996cited by this paper
• Leptomeningeal Carcinomatosis: Presenting Features and Prognostic Factors

  1996cited by this paper
• A comparison of polymerase chain reaction examination of cerebrospinal fluid and conventional cytology in the diagnosis of lymphomatous meningitis

  1996cited by this paper
• Carcinomatous meningitis in solid tumours.

  1996cited by this paper
• Neurologic Complications of Cancer.

  1996cited by this paper
• Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis

  1995cited by this paper
• Diagnosis, management, and survival of patients with leptomeningeal cancer based on cerebrospinal fluid‐flow status

  1995cited by this paper
• Neurotoxicity and pharmacokinetics of ventriculolumbar perfusion of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-gluco-pyranoside (MCNU) in dogs

  1994cited by this paper
• Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats.

  1994cited by this paper
• Intrathecal administration of interleukin-2 for meningeal carcinomatosis due to malignant melanoma: sequential evaluation of intracranial pressure, cerebrospinal fluid cytology, and cytokine induction.

  1993cited by this paper
• Cerebrospinal Fluid in Diseases of the Nervous System

  1993cited by this paper
• Extended CSF cytarabine exposure following intrathecal administration of DTC 101.

  1993cited by this paper
• Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: a Pediatric Oncology Group study.

  1993cited by this paper
• Cerebrospinal Fluid (CSF) Cytology: Current Status and Diagnostic Applications

  1992cited by this paper
• Intrathecal dacarbazine treatment of leptomeningeal malignant melanoma.

  1992cited by this paper
• Cerebrospinal fluid tumour markers in patients treated for meningeal malignancy.

  1991cited by this paper
• Neurotoxicity of intraventricularly administered alpha‐interferon for leptomeningeal disease

  1991cited by this paper
• Relapse in the central nervous system in melanoma patients successfully treated with biomodulators.

  1989cited by this paper
• The role of postoperative radiotherapy after resection of single brain metastases.

  1989influential reference
• The intracerebral penetration of intraventricularly administered methotrexate: A quantitative autoradiographic study

  1989cited by this paper
• Spinal cord penetration of intrathecally administered cytarabine and methotrexate: a quantitative autoradiographic study.

  1988cited by this paper
• Cerebrospinal fluid tumor markers for the diagnosis and management of leptomeningeal metastases.

  1987cited by this paper
• Pharmacology and toxicity of high-dose cytarabine by 72-hour continuous infusion.

  1986cited by this paper
• Pharmacokinetics of trimetrexate (NSC 352122) in monkeys.

  1986cited by this paper
• A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast.

  1984cited by this paper
• Successful treatment of meningeal leukemia using systemic high-dose cytosine arabinoside.

  1984cited by this paper
• Effect of dose and schedule on pharmacokinetics of high-dose cytosine arabinoside in plasma and cerebrospinal fluid.

  1983cited by this paper
• Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using 111indium-DTPA ventriculography.

  1982cited by this paper
• Diagnosis and treatment of leptomeningeal metastases from solid tumors: Experience with 90 patients

  1982influential reference
• Meningeal carcinomatosis in small cell carcinoma of the lung.

  1982cited by this paper
• Cerebrospinal fluid biochemical markers of central nervous system metastases

  1980cited by this paper
• Treatment of meningeal neoplasms.

  1977cited by this paper
• Treatment of malignant meningeal disease with intrathecal thioTEPA: a phase II study.

  1977cited by this paper
• Intrathecal n, n′, n′‐triethylenethiophosphoramide [thio‐tepa (NSC 6396)] in the treatment of malignant meningeal disease. Phase I‐II study

  1976cited by this paper
• Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections.

  1975cited by this paper
• The influence of previous lumbar puncture and pneumoencephalography on the incidence of unsuccessful radioisotope cisternography.

  1971cited by this paper

• Treatment strategies for leptomeningeal disease in patients with breast cancer.

  2025cites this paper
• Intradural Spinal Malignant Peripheral Nerve Sheath Tumor on 18F-FDG PET/CT.

  2025cites this paper
• Spine Metastasis Is Associated with the Development of Brain Metastasis in Non-Small-Cell Lung Cancer Patients

  2024cites this paper
• Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells

  2024cites this paper
• Top Ten Tips Palliative Care Clinicians Should Know About Caring for People with Leptomeningeal Disease

  2024cites this paper
• Risk of leptomeningeal metastasis in children with parameningeal rhabdomyosarcoma with intracranial spread

  2023cites this paper
• Performance evaluation of the automated body fluid analysis of the new Sysmex XR haematology analyser

  2023cites this paper
• International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

  2022cites this paper
• Leptomeningeal metastasis from non-small cell lung cancer— a post-hoc analysis from four randomised clinical trials

  2022cites this paper
• Advances in Diagnosis and Treatment for Leptomeningeal Disease in Melanoma

  2022cites this paper
• Leptomeningeal carcinomatosis in small cell carcinoma of the prostate

  2022cites this paper
• Breast to Brain: A Case Report and Literature Review of Leptomeningeal Carcinomatosis

  2022cites this paper
• Dynamic Mutational Landscape of CSF Circulating Tumor DNA and Predictors of Survival after Proton Craniospinal Irradiation for Leptomeningeal Metastases.

  2022cites this paper
• www.clinicalcases.eu Archive of Clinical Cases

  2022cites this paper
• Impact of cerebrospinal fluid flow study in patients undergoing intrathecal chemotherapy via ventricular catheter reservoir

  2021cites this paper
• Bilateral retinal artery occlusions as the first manifestation of extramedullary central nervous system involvement in relapsed acute myeloid leukaemia

  2021cites this paper
• Quantitative cerebrospinal fluid circulating tumor cells are a potential biomarker of response for proton craniospinal irradiation for leptomeningeal metastasis

  2021cites this paper
• Status Epilepticus as the Presenting Complication of Adenocarcinoma Lung in a Young Male

  2021cites this paper
• Autocrine GMCSF Signaling Contributes to Growth of HER2+ Breast Leptomeningeal Carcinomatosis

  2021cites this paper
• Inhibition of Jumonji Histone Demethylases Selectively Suppresses HER2+ Breast Leptomeningeal Carcinomatosis Growth via Inhibition of GMCSF Expression

  2021cites this paper
• Garcin Syndrome Due to Meningeal Carcinomatosis from Gastric Cancer

  2020cites this paper
• GM-CSF signaling is critical for HER2+ breast leptomeningeal carcinomatosis

  2020cites this paper
• An overview of leptomeningeal disease.

  2020cites this paper
• A 51-year-old woman with binocular diplopia and unilateral ptosis.

  2019cites this paper
• CEREBROSPINAL FLUID CYTOLOGY IN CANCER PATIENTS: AN INSTITUTIONAL STUDY WITH 5394 CASES -

  2017cites this paper
• Leptomeningeal disease: current diagnostic and therapeutic strategies

  2017cites this paper
• Dysphagia and anorexia as presentations of leptomeningeal carcinomatosis

  2016cites this paper
• Efficacy of Intrathecal MTX/Ara-C Combined with Systemic Chemotherapy in a Gastric Cancer Patient with Meningeal Carcinomatosis.

  2016cites this paper
• Nimotuzumab treatment and outcome analysis in patients with leptomeningeal metastasis from nonsmall cell lung cancer.

  2016cites this paper
• [A clinical case of combined treatment of a patient with breast cancer and metastases to the brain and meninges].

  2016cites this paper
• Chronic Meningitis: Simplifying a Diagnostic Challenge

  2016cites this paper
• Palliative care and pediatric surgical oncology.

  2016cites this paper
• Whole brain radiotherapy in management of non-small-cell lung carcinoma associated leptomeningeal carcinomatosis: evaluation of prognostic factors

  2016cites this paper
• Brain metastasis: clinical characteristics, pathological findings and molecular subtyping for therapeutic implications

  2015cites this paper
• Headache in a young woman: leptomeningeal metastasis as the first presentation of underlying breast malignancy

  2015cites this paper
• Leptomeningeal carcinomatosis from gastric cancer: single institute retrospective analysis of 9 cases

  2014cites this paper
• En plaque spinal leptomeningeal carcinomatosis from metastatic melanoma.

  2014cites this paper
• Central nervous system infections in cancer patients and hematopoietic stem cell transplant recipients.

  2014cites this paper
• Carcinomatous meningitis due to gastric adenocarcinoma: A rare presentation of relapse.

  2014cites this paper
• Telomeraseaktivitätsmessung mittels Real- Time PCR zur Differenzierung benigner und maligner Liquorpleozytosen

  2014cites this paper
• Molecular profiling of tumor cells in cerebrospinal fluid and matched primary tumors from metastatic breast cancer patients with leptomeningeal carcinomatosis.

  2013cites this paper
• Cerebrospinal fluid concentrations of gefitinib in patients with lung adenocarcinoma.

  2013cites this paper
• Diagnostic Accuracy of Cerebrospinal Fluid (CSF) Cytology in Metastatic Tumors: An Analysis of Consecutive CSF Samples

  2013cites this paper
• Leptomeningeal Metastasis from Prostate Cancer

  2013cites this paper
• Central nervous system prophylaxis with intrathecal liposomal cytarabine in diffuse large B-cell lymphomas.

  2013cites this paper
• Leiomyosarcoma Leptomeningeal Brain Metastases

  2012cites this paper
• Flow cytometry as a diagnostic tool in lymphomatous or leukemic meningitis

  2012cites this paper
• Clinical Features and Prognostic Factors in Patients with Carcinomatous Meningitis Secondary to Breast Cancer

  2012cites this paper
• Losing all sense: a case of meningeal carcinomatosis

  2011cites this paper
• Benefit of ventriculoperitoneal cerebrospinal fluid shunting and intrathecal chemotherapy in neoplastic meningitis: a retrospective, case-controlled study.

  2011cites this paper
• Brain metastasis and leptomeningeal carcinomatosis in a patient with cholangiocarcinoma.

  2011cites this paper
• Non-small cell lung carcinoma presenting as carcinomatous meningitis

  2010cites this paper
• Gastric leptomeningeal carcinomatosis: multi-center retrospective analysis of 54 cases.

  2009cites this paper
• Efficacy and safety of liposomal cytarabine in lymphoma patients with central nervous system involvement from lymphoma

  2009cites this paper
• Need for a new treatment strategy: leptomeningeal carcinomatosis from gastric cancer

  2009cites this paper
• Chronic meningitis

  2009cites this paper
• Chronic and recurrent meningitis

  2008cites this paper
• Continuous intrathecal treatment with methotrexate via subcutaneous port: implication for leptomeningeal dissemination of malignant tumors

  2008cites this paper
• Diagnosis of Metastatic Tumors in Cerebrospinal Fluid Samples Using Thin-Layer Cytology

  2008cites this paper
• Chronische Meningitis

  2007cites this paper
• Management of Brain Metastases: Neurosurgical Considerations

  2007cites this paper
• Treatment of central nervous system metastases: parenchymal, epidural, and leptomeningeal

  2006cites this paper
• Chemotherapy in neoplastic meningitis.

  2006cites this paper
• Pharmacology of Drugs Formulated with DepoFoam™

  2006cites this paper