Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage

No abstract is available for this paper.

• Publication year

  2006

• Venue

  European Journal of Neuroscience

• Publication date

  2006-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1460-9568.2006.05123.xPMID 17074049
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease.

  2006cited by this paper
• Chemical genetic analysis of the time course of signal transduction by JNK.

  2006cited by this paper
• The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

  2006cited by this paper
• Akt Contributes to Neuroprotection by Hypothermia against Cerebral Ischemia in Rats

  2005cited by this paper
• Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway

  2005influential reference
• Tumor necrosis factor: an apoptosis JuNKie?

  2004cited by this paper
• Ischemic Preconditioning: Neuronal Survival in the Face of Caspase-3 Activation

  2004influential reference
• Hypothermic Preconditioning Increases Survival of Purkinje Neurons in Rat Cerebellar Slices after an In Vitro Simulated Ischemia

  2004cited by this paper
• Tumor Necrosis Factor Receptor 1 and Its Signaling Intermediates Are Recruited to Lipid Rafts in the Traumatized Brain

  2004cited by this paper
• Tumor Necrosis Factor &agr; Expression and Protein Levels after Fluid Percussion Injury in Rats: The Effect of Injury Severity and Brain Temperature

  2004cited by this paper
• Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation

  2003cited by this paper
• Targeting JNK for therapeutic benefit: from junk to gold?

  2003cited by this paper
• Caspase 3 activation is essential for neuroprotection in preconditioning

  2003influential reference
• Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

  2003cited by this paper
• Ischemic tolerance and endogenous neuroprotection.

  2003influential reference
• Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal‐regulating kinase 1 during seizure‐induced neuronal death

  2003cited by this paper
• JunD mediates survival signaling by the JNK signal transduction pathway.

  2003cited by this paper
• Jun NH2-terminal Kinase (JNK) Interacting Protein 1 (JIP1) Binds the Cytoplasmic Domain of the Alzheimer's β-Amyloid Precursor Protein (APP)*

  2002cited by this paper
• NF-κB at the crossroads of life and death

  2002cited by this paper
• Differential Roles of JIP Scaffold Proteins in the Modulation of Amyloid Precursor Protein Metabolism*

  2002cited by this paper
• IAP proteins: blocking the road to death's door

  2002cited by this paper
• NF-kappaB at the crossroads of life and death.

  2002cited by this paper
• IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition

  2002influential reference
• Ischemic Tolerance

  2002cited by this paper
• Targeting the JNK pathway for therapeutic benefit in CNS disease.

  2002cited by this paper
• Potential of anticytokine therapies in central nervous system ischaemia

  2001cited by this paper
• Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation

  2001cited by this paper
• Baculoviruses and apoptosis: the good, the bad, and the ugly

  2001cited by this paper
• Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

  2001cited by this paper
• Apoptotic and Anti‐Apoptotic Mechanisms Following Spinal Cord Injury

  2001cited by this paper
• Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans

  2001cited by this paper
• c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK

  2001cited by this paper
• Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

  2001cited by this paper
• NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

  2001cited by this paper
• The role of TNF and its receptors in Alzheimer's disease.

  2001cited by this paper
• Apoptotic and Antiapoptotic Mechanisms after Traumatic Brain Injury

  2001cited by this paper
• ASK1-signaling promotes c-Myc protein stability during apoptosis.

  2001cited by this paper
• Inhibition of JNK activation through NF-kappaB target genes.

  2001cited by this paper
• NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B.

  2001cited by this paper
• Characterization of the neurotrophic interaction between nerve growth factor and secreted α‐amyloid precursor protein

  2001cited by this paper
• Glial expression of tumor necrosis factor in transgenic animals: How do these models reflect the “normal situation”?

  2001cited by this paper
• Inhibition of JNK activation through NF-κB target genes

  2001cited by this paper
• Neuronal ischaemic preconditioning.

  2000cited by this paper
• Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.

  2000cited by this paper
• Importance of Posttraumatic Hypothermia and Hyperthermia on the Inflammatory Response after Fluid Percussion Brain Injury: Biochemical and Immunocytochemical Studies

  2000cited by this paper
• Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment.

  1999cited by this paper
• XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1–TAK1 in the BMP signaling pathway

  1999cited by this paper
• Induction of tolerance against traumatic brain injury by ischemic preconditioning.

  1999cited by this paper
• The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.

  1998cited by this paper
• The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

  1998cited by this paper
• IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases

  1998cited by this paper
• gThe Dorothy Russell Memorial Lecture* The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms

  1998cited by this paper
• Protective Effects of Moderate Hypothermia on Behavioral Deficits But Not Necrotic Cavitation Following Cortical Impact Injury in the Rat

  1998cited by this paper
• Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

  1998cited by this paper
• Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.

  1997cited by this paper
• Activation of CPP32 during apoptosis of neurons and astrocytes

  1997cited by this paper
• Rapid ischemic preconditioning protects rats from cerebral anoxia/ischemia.

  1997cited by this paper
• Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant.

  1997influential reference
• Postischemic hypothermia. A critical appraisal with implications for clinical treatment.

  1997cited by this paper
• Temporal and Regional Patterns of Axonal Damage following Traumatic Brain Injury: A Beta‐amyloid Precursor Protein Immunocytochemical Study in Rats

  1997cited by this paper
• The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration.

  1997cited by this paper
• Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue

  1997cited by this paper
• Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS.

  1996influential reference
• Inhibition of Tumor Necrosis Factor Alpha (TNFα) Activity in Rat Brain is Associated with Cerebroprotection after Closed Head Injury

  1996influential reference
• Brain damage and temperature: cellular and molecular mechanisms.

  1996cited by this paper
• Unifying hypothesis for the pathogenesis of HIV-associated dementia complex, vacuolar myelopathy, and sensory neuropathy.

  1995cited by this paper
• Signal transduction by tumor necrosis factor mediated by JNK protein kinases

  1994cited by this paper
• Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat

  1994cited by this paper
• The stress-activated protein kinase subfamily of c-Jun kinases

  1994cited by this paper
• Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand.

  1993influential reference
• Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury

  1991influential reference
• 'Ischemic tolerance' phenomenon found in the brain.

  1990cited by this paper

• Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia

  2025cites this paper
• A review on targeted temperature management for cardiac arrest and traumatic brain injury

  2024cites this paper
• Investigating the Safety and Efficacy of Therapeutic Hypothermia in Pediatric Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis

  2024cites this paper
• Cerebrospinal fluid flushing as a means of neuroprotection

  2023cites this paper
• Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea

  2021cites this paper
• Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

  2020cites this paper
• Cognitive Effects of Astaxanthin Pretreatment on Recovery From Traumatic Brain Injury

  2020cites this paper
• A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury

  2019cites this paper
• Anatomical Correlates and Surgical Considerations for Localized Therapeutic Hypothermia Application in Cochlear Implantation Surgery

  2019cites this paper
• Therapeutic hypothermia and mortality in the intensive care unit: systematic review and meta-analysis.

  2019cites this paper
• Study of Repetitive Brain Injury

  2018cites this paper
• Therapeutic Hypothermia in the Pediatric ICU

  2018cites this paper
• Inflammatory Mechanisms in Mediating Hearing Loss

  2018cites this paper
• Potential role of c-Jun N-terminal kinase in ischemic preconditioning and neuroprotection

  2018influential citation
• Trauma, inflammation, cochlear implantation induced hearing loss and otoprotective strategies to limit hair cell death and hearing loss

  2018cites this paper
• Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury

  2017cites this paper
• Hypothermia for Traumatic Brain Injury

  2017cites this paper
• Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia

  2017cites this paper
• Retracted: Sex and Age Differences in Epinephrine Mechanisms and Outcomes after Brain Injury

  2017cites this paper
• Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients*

  2017cites this paper
• Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways

  2017cites this paper
• Selective Brain Hypothermia Mitigates Brain Damage and Improves Neurological Outcome after Post-Traumatic Decompressive Craniectomy in Mice

  2017cites this paper
• K channel impairment determines sex and age differences in epinephrine‐mediated outcomes after brain injury

  2017cites this paper
• Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

  2016cites this paper
• Mitogen-activated kinase pathway activation in epidermal lamellae in the acute stages of carbohydrate overload laminitis models and the effect of regional deep hypothermia on signalling pathways.

  2016cites this paper
• Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

  2016cites this paper
• Implantable Multimodal Sensor: For the Improved Management of Traumatic Brain Injury and Hydrocephalus

  2016cites this paper
• A New Tool for the Neurointensive Care Unit: Simultaneous Measurement of Temperature From a Catheter-Tip Pressure Sensor

  2015cites this paper
• Lamellar Mitogen-Activated Protein Kinase and Hypoxia Signaling in a Sepsis-Related Laminitis Model and a Novel Supporting Limb Laminitis Model

  2015influential citation
• Hypoxia-Ischemia and Therapeutic Hypothermia in the Neonatal Mouse Brain – A Longitudinal Study

  2015cites this paper
• Vascular Actions of Hypothermia in Brain Trauma

  2014cites this paper
• Adenosine 5'-monophosphate-induced hypothermia inhibits the activation of ERK1/2, JNK, p38 and NF-κB in endotoxemic rats.

  2014cites this paper
• Tumor Necrosis Factor in Traumatic Brain Injury: Effects of Genetic Deletion of p55 or p75 Receptor

  2013cites this paper
• Fundamental research progress of mild hypothermia in cerebral protection

  2013cites this paper
• MicroRNA overexpression increases cortical neuronal vulnerability to injury.

  2013cites this paper
• Tumor necrosis factor in traumatic brain injury : effects of genetic deletion of p 55 or p 75 receptor

  2013cites this paper
• Effect of neuroprotective therapies (hypothermia and cyclosporine a) on dopamine-induced apoptosis in human neuronal SH-SY5Y cells

  2013cites this paper
• [Prolonged hypothermia in refractory intracranial hypertension. Report of one case].

  2012cites this paper
• Neuroprotective Effects of Hypothermia After Spinal Cord Injury in Rats: Comparative Study Between Epidural Hypothermia and Systemic Hypothermia

  2012cites this paper
• Posttraumatic hypothermia increases doublecortin expressing neurons in the dentate gyrus after traumatic brain injury in the rat.

  2012cites this paper
• Pre-hospital hypothermia is not associated with increased survival after traumatic brain injury.

  2012cites this paper
• Hipotermia intravascular prolongada en un paciente con hipertensión endocraneana refractaria

  2012cites this paper
• Molecular and Cellular Pathways as a Target of Therapeutic Hypothermia: Pharmacological Aspect

  2012cites this paper
• Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury.

  2012cites this paper
• ASSOCIATION FOR ACADEMIC SURGERY Pre-Hospital Hypothermia is Not Associated with Increased Survival After Traumatic Brain Injury 1

  2012cites this paper
• Current Understanding and Experimental Approaches to the Study of Repetitive Brain Injury

  2012cites this paper
• Effects of Therapeutic Hypothermia on Inflammasome Signaling after Traumatic Brain Injury

  2012cites this paper
• Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge

  2012cites this paper
• Current Concepts of Hypothermia in Traumatic Brain Injury

  2011cites this paper
• Hypothermia in Traumatic Brain Injury – A Literature Review

  2011cites this paper
• The evidence for hypothermia as a neuroprotectant in traumatic brain injury

  2011cites this paper
• Mild hypothermia causes differential, time-dependent changes in cytokine expression and gliosis following endothelin-1-induced transient focal cerebral ischemia

  2011cites this paper
• Hypothermic Treatment for Acute Spinal Cord Injury

  2011cites this paper
• Oligodendrocyte Vulnerability Following Traumatic Brain Injury in Rats: Effect of Moderate Hypothermia

  2011cites this paper
• The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

  2010cites this paper
• Post‐traumatic seizure susceptibility is attenuated by hypothermia therapy

  2010cites this paper
• Genetic Analysis of the Role of Tumor Necrosis Factor Receptors in Functional Outcome after Traumatic Brain Injury in Mice

  2010cites this paper
• Induced Hypothermia for Trauma: Current Research and Practice

  2010cites this paper
• Hypothermia and C3 peptide promote neurite outgrowth and regeneration after traumatic CNS injury

  2010cites this paper
• α-Synuclein Levels Are Elevated in Cerebrospinal Fluid following Traumatic Brain Injury in Infants and Children: The Effect of Therapeutic Hypothermia

  2010cites this paper
• Alterations in gene expression after induction of profound hypothermia for the treatment of lethal hemorrhage.

  2010cites this paper
• Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Hypothermia in Bleeding Trauma: a Friend or a Foe?

  2009cites this paper
• Hypothermia‐Induced Neurite Outgrowth is Mediated by Tumor Necrosis Factor‐Alpha

  2009cites this paper
• The Effect of Hypothermia on the Expression of TIMP-3 after Traumatic Brain Injury in Rats

  2009cites this paper
• Induced Mild Hypothermia in Children after Brain Injury

  2009cites this paper
• Activation of NR2B and Autophagy Signaling Pathways Following Traumatic Brain Injury

  2009influential citation
• Protection in Animal Models of Brain and Spinal Cord Injury with Mild to Moderate Hypothermia

  2009cites this paper
• Effect of Post-Traumatic Mild Hypothermia on Hippocampal Cell Death after Traumatic Brain Injury in Rats

  2009cites this paper
• A Novel Protein Complex in Membrane Rafts Linking the NR2B Glutamate Receptor and Autophagy Is Disrupted following Traumatic Brain Injury

  2009influential citation
• Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways.

  2008cites this paper
• Targeting TNF-alpha receptors for neurotherapeutics.

  2008cites this paper
• Tumor necrosis factor-α-induced sickness behavior is impaired by central administration of an inhibitor of c-jun N-terminal kinase

  2008cites this paper
• potentiates iron-induced formation of species.

  2008cites this paper
• Opposing Roles for Reactive Astrocytes following Traumatic Brain Injury

  2008cites this paper
• Effect on gene expression of therapeutic hypothermia in cerebral ischemia

  2007cites this paper
• Altered cytokine expression and sustained hypothermia following traumatic brain injury in heat acclimated mice.

  2007cites this paper
• Neuron-specific phosphorylation of c-Jun N-terminal kinase increased in the brain of hypoxic preconditioned mice.

  2007cites this paper
• Hypothermia treatment potentiates ERK1/2 activation after traumatic brain injury

  2007cites this paper
• Hypothermia in traumatic brain injury — a literature review

  year unknowncites this paper