Conditioned stimulus familiarity determines effects of MK-801 on fear extinction.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Behavioral Neuroscience

• Publication date

  2009-04-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1037/a0014988PMID 19331454
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear.

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• The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat.

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• Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats

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• Reinstatement of fear to an extinguished conditioned stimulus: two roles for context.

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• Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus.

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• The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

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• Distinct components of spatial learning revealed by prior training and NMDA receptor blockade

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• Spatial learning without NMDA receptor-dependent long-term potentiation

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• The NMDA Receptor Antagonist MK-801 Blocks Acquisition and Extinction of Conditioned Hypoalgesic Responses in the Rat

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• Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala

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• N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.

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• Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

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• Brain Mechanisms Controlling Pavlovian Fear Conditioning

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• Pharmacological evidence that a failure to recruit NMDA receptors contributes to impaired fear extinction retention in adolescent rats

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
• Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys

  2015cites this paper
• Relearning a context-shock association after forgetting is an NMDAr-independent process.

  2015cites this paper
• Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

  2014cites this paper
• Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders

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• Benzodiazepine administration prevents the use of error-correction mechanisms during fear extinction

  2014cites this paper
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• Animal models of serotonergic psychedelics.

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• Traces of memory: reacquisition of fear following forgetting is NMDAr-independent.

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• Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models.

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• Comparison of the MK-801-induced appetitive extinction deficit with pressing for reward and associated pERK1/2 staining in prefrontal cortex and nucleus accumbens.

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• Acute, but not chronic, exposure to d-cycloserine facilitates extinction and modulates spontaneous recovery of a conditioned taste aversion.

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• Delayed Effects of NMDA Receptor Antagonist MK-801 on Storage and Reconsolidation of Spatial Memory in Rats

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• NMDA receptors and fear extinction: implications for cognitive behavioral therapy

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• Memory of fearful events: the role of fibroblast growth factor-2 in fear acquisition and extinction.

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• MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation.

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• Fibroblast growth factor-2 alters the nature of extinction.

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• Role of the basolateral amygdala and NMDA receptors in higher-order conditioned fear

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• The Basolateral Amygdala Is Critical for the Acquisition and Extinction of Associations between a Neutral Stimulus and a Learned Danger Signal But Not between Two Neutral Stimuli

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• The effect of D-cycloserine on immediate vs. delayed extinction of learned fear.

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• The temporal specificity of the switch from NMDAr-dependent extinction to NMDAr-independent re-extinction.

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• Extinction in preweanling rats does not involve NMDA receptors.

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• US habituation, like CS extinction, produces a decrement in conditioned fear responding that is NMDA dependent and subject to renewal and reinstatement.

  2010cites this paper