Ginsenoside Rg3 ameliorates lipopolysaccharide-induced acute lung injury in mice through inactivating the nuclear factor-κB (NF-κB) signaling pathway.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  International Immunopharmacology

• Publication date

  2016-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.intimp.2016.02.011PMID 26921732
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• COX-2 inhibition attenuates lung injury induced by skeletal muscle ischemia reperfusion in rats.

  2016cited by this paper
• Ginsenoside Rg3 attenuated omethoate-induced lung injury in rats

  2016cited by this paper
• Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion injury via Akt/endothelial nitric oxide synthase signaling and the B‑cell lymphoma/B‑cell lymphoma‑associated X protein pathway.

  2015cited by this paper
• Ginsenoside Rd and ischemic stroke; a short review of literatures

  2015cited by this paper
• Intracranial aneurysms in sickle cell anemia: clinical and imaging findings

  2015cited by this paper
• Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome

  2015cited by this paper
• Fisetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury via TLR4-Mediated NF-κB Signaling Pathway in Rats

  2015cited by this paper
• Polydatin attenuates ipopolysaccharide-induced acute lung injury in rats.

  2014cited by this paper
• Chronic inflammatory diseases and the Acute Respiratory Distress Syndrome (ARDS).

  2014cited by this paper
• Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation

  2014cited by this paper
• Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats

  2014cited by this paper
• Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88-dependent Toll-like receptor 4 signaling pathway.

  2014cited by this paper
• Treating ARDS: new hope for a tough problem.

  2014cited by this paper
• Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments by Anti-Inflammatory Activity in Rats

  2013cited by this paper
• Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma.

  2013cited by this paper
• Autopsy in ARDS: insights into natural history.

  2013cited by this paper
• Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB

  2013cited by this paper
• The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage.

  2013cited by this paper
• Effects of COX-2 inhibitor on ventilator-induced lung injury in rats.

  2013cited by this paper
• Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells

  2013cited by this paper
• Sinomenine Protects against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Adenosine A2A Receptor Signaling

  2013cited by this paper
• Pharmacological therapies for pediatric and neonatal ALI/ARDS: an evidence-based review.

  2012cited by this paper
• Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury

  2012cited by this paper
• Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice.

  2012cited by this paper
• Regulation of alveolar fluid clearance and ENaC expression in lung by exogenous angiotensin II.

  2012cited by this paper
• The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material

  2012cited by this paper
• Lipopolysaccharide and Sphingosine-1-Phosphate Cooperate To Induce Inflammatory Molecules and Leukocyte Adhesion in Endothelial Cells

  2012cited by this paper
• Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway

  2012cited by this paper
• Insulin up-regulates epithelial sodium channel in LPS-induced acute lung injury model in rats by SGK1 activation.

  2012cited by this paper
• Gene therapy for ALI/ARDS.

  2011cited by this paper
• ALI and ARDS: challenges and advances.

  2011cited by this paper
• Hydrogen Sulfide Upregulates Cyclooxygenase-2 and Prostaglandin E Metabolite in Sepsis-Evoked Acute Lung Injury via Transient Receptor Potential Vanilloid Type 1 Channel Activation

  2011cited by this paper
• Regulation of epithelial sodium channel α-subunit expression by adenosine receptor A₂a in alveolar epithelial cells.

  2011cited by this paper
• Up-regulation of Heme Oxygenase-1 by Korean Red Ginseng Water Extract as a Cytoprotective Effect in Human Endothelial Cells

  2011cited by this paper
• Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury.

  2010cited by this paper
• Ginsenoside Rg3 inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells.

  2010cited by this paper
• 20(S)‐ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain

  2009cited by this paper
• Ginsenosides chemistry, biosynthesis, analysis, and potential health effects.

  2009cited by this paper
• Glucocorticoid resistance in inflammatory diseases.

  2009cited by this paper
• Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.

  2008cited by this paper
• Role of corticosteroids in the management of acute respiratory distress syndrome.

  2008cited by this paper
• Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation.

  2008cited by this paper
• Hydrocortisone therapy for patients with septic shock.

  2008cited by this paper
• p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway.

  2008cited by this paper
• BERBERINE INHIBITS CYTOSOLIC PHOSPHOLIPASE A2 AND PROTECTS AGAINST LPS-INDUCED LUNG INJURY AND LETHALITY INDEPENDENT OF THE α2-ADRENERGIC RECEPTOR IN MICE

  2007cited by this paper
• Acute lung injury and the acute respiratory distress syndrome: a clinical review.

  2007cited by this paper
• Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells.

  2006cited by this paper
• Pulmonary edema after transfusion: How to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury

  2006cited by this paper
• Duration and Intensity of NF-κB Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury1

  2006cited by this paper
• NF-kappa B activation as a pathological mechanism of septic shock and inflammation.

  2006cited by this paper
• NF-κB activation as a pathological mechanism of septic shock and inflammation

  2006cited by this paper
• Cyclooxygenase 2 Plays a Pivotal Role in the Resolution of Acute Lung Injury1

  2005cited by this paper
• Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria.

  2005cited by this paper
• Andrographolide interferes with binding of nuclear factor‐κB to DNA in HL‐60‐derived neutrophilic cells

  2005cited by this paper
• Ethanol Blocks Leukocyte Recruitment and Endothelial Cell Activation In Vivo and In Vitro1

  2004cited by this paper
• Neutrophils and acute lung injury

  2003cited by this paper
• In vivo lipid‐derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS

  2002cited by this paper
• Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury.

  2002cited by this paper
• Adenoviral E3-14.7K protein in LPS-induced lung inflammation.

  2000cited by this paper
• Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.

  2000cited by this paper
• NF-kappaB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome.

  2000cited by this paper
• The acute respiratory distress syndrome.

  2000cited by this paper
• The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation.

  1999cited by this paper
• The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation*

  1999cited by this paper
• Duration of glucocorticoid treatment and outcome in sepsis: is the right drug used the wrong way?

  1998cited by this paper
• Established Acute Respiratory Distress Syndrome: Benefit of Corticosteroid Rescue Therapy

  1998cited by this paper
• Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion

  1996cited by this paper
• The acute respiratory distress syndrome.

  1996cited by this paper
• Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.

  1996cited by this paper
• Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock

  1991cited by this paper

• Pharmacological targeting of ferroptosis in hypoxia-induced pulmonary edema: therapeutic potential of ginsenoside Rg3 through activation of the PI3K/AKT pathway

  2025cites this paper
• Unlocking ginsenosides’ therapeutic power with polymer-based delivery systems: current applications and future perspectives

  2025cites this paper
• A comprehensive review of the effects of Panax ginseng and its constituents against inflammatory diseases

  2025cites this paper
• Beyond the pill: incrimination of nuclear factor-kappa B and their targeted phytomedicine for pulmonary fibrosis

  2025cites this paper
• Pharmacological mechanisms of traditional Chinese medicine against acute lung injury: From active ingredients to herbal formulae.

  2024cites this paper
• Recent trends in ginseng research

  2024cites this paper
• Ginsenoside Rk1 exerts protective effects of LPS-induced podocyte apoptosis and inflammation by inactivating JAK2/STAT3 and NF-κB pathways

  2024cites this paper
• Metabolic Reprograming of Macrophages: A New Direction in Traditional Chinese Medicine for Treating Liver Failure

  2024cites this paper
• Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity

  2024cites this paper
• New perspective on the immunomodulatory activity of ginsenosides: Focus on effective therapies for post-COVID-19.

  2023cites this paper
• Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease.

  2023cites this paper
• The Protective Effect and Mechanism of a Phytochemical Extract from the Wild Vegetable Shutou (Crateva unilocularis Buch.) against Acetaminophen-Induced Liver Injury in Mice

  2023cites this paper
• Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury

  2023cites this paper
• Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora

  2023cites this paper
• Investigation to the Expression of Cytokines in Serum of Rabbits with Acute Lung Injury Interposed by Different Doses Ulinastatin in Underwater Explosion

  2022cites this paper
• Recent advances in ginsenosides against respiratory diseases: Therapeutic targets and potential mechanisms.

  2022cites this paper
• Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice

  2021cites this paper
• RETRACTED ARTICLE: Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1/miR-200c-3p/SIRT1 axis

  2021cites this paper
• Elucidation of the Mechanism of Action of Ginseng Against Acute Lung Injury/Acute Respiratory Distress Syndrome by a Network Pharmacology-Based Strategy

  2021cites this paper
• Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

  2020cites this paper
• Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly

  2020cites this paper
• Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4

  2020cites this paper
• Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury

  2020influential citation
• Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion-induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway

  2019cites this paper
• Ginseng: A Qualitative Review of Benefits for Palliative Clinicians

  2019cites this paper
• Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4–MyD88–NF-κB signaling pathway

  2019cites this paper
• The protective effect of the flavonoid fraction of Abutilon theophrasti Medic. leaves on LPS-induced acute lung injury in mice via the NF-κB and MAPK signalling pathways.

  2019cites this paper
• Pseudoginsenoside-F11 Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Neutrophil Infiltration and Accelerating Neutrophil Clearance

  2019cites this paper
• Advances in research into the mechanisms of Chinese Materia Medica against acute lung injury.

  2019cites this paper
• 20(R)‐ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen‐induced hepatotoxicity by suppressing PI3K/AKT pathway‐mediated inflammation and apoptosis

  2018cites this paper
• Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

  2018cites this paper
• 3,4,5‐Trihydroxycinnamic acid attenuates lipopolysaccharide (LPS)‐induced acute lung injury via downregulating inflammatory molecules and upregulating HO‐1/AMPK activation

  2018cites this paper
• Protective Effect of Jianpiyifei II Granule against Chronic Obstructive Pulmonary Disease via NF-κB Signaling Pathway

  2018cites this paper
• Functional mechanism of Ginsenosides on tumor growth and metastasis

  2018influential citation
• Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway

  2018cites this paper
• Cellular stress response mechanisms as therapeutic targets of ginsenosides

  2018cites this paper
• Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARγ.

  2017cites this paper
• Application of magnetically immobilized edible fungus for the biotransformation of panax notoginseng saponin Rb1 to Rd and Rg3.

  2017cites this paper
• Ginsenoside Rg 3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT 5-PPAR γ

  2017cites this paper
• The Role of Biologically Active Ingredients from Chinese Herbal Medicines in the Regulation of Autophagy in Treating Cardiovascular Diseases and Other Chronic Diseases.

  2017cites this paper
• Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice.

  2017cites this paper
• Ginsenoside Rg3 promotes inflammation resolution through M2 macrophage polarization

  2017cites this paper
• Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K

  2016cites this paper