Predictability of Survival Models for Waiting List and Transplant Patients: Calculating LYFT

‘Life years from transplant’ (LYFT) is the extra years of life that a candidate can expect to achieve with a kidney transplant as compared to never receiving a kidney transplant at all. The LYFT component survival models (patient lifetimes with and without transplant, and graft lifetime) are comparable to or better predictors of long‐term survival than are other predictive equations currently in use for organ allocation. Furthermore, these models are progressively more successful at predicting which of two patients will live longer as their medical characteristics (and thus predicted lifetimes) diverge. The C‐statistics and the correlations for the three LYFT component equations have been validated using independent, nonoverlapping split‐half random samples. Allocation policies based on these survival models could lead to substantial increases in the number of life years gained from the current donor pool.

• Publication year

  2009

• Venue

  American Journal of Transplantation

• Publication date

  2009-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1600-6143.2009.02708.xPMID 19656143
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Comprehensive Risk Quantification Score for Deceased Donor Kidneys: The Kidney Donor Risk Index

  2009cited by this paper
• Calculating Life Years from Transplant (LYFT): Methods for Kidney and Kidney‐Pancreas Candidates

  2008cited by this paper
• Re-weighting the model for end-stage liver disease score components.

  2008cited by this paper
• Prospective breast cancer risk prediction model for women undergoing screening mammography.

  2006cited by this paper
• C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring Study

  2004cited by this paper
• COMPARISON OF MORTALITY IN ALL PATIENTS ON DIALYSIS , PATIENTS ON DIALYSIS AWAITING TRANSPLANTATION , AND RECIPIENTS OF A FIRST CADAVERIC TRANSPLANT

  2000cited by this paper
• Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.

  1999cited by this paper

• Optimizing Kidney Allograft Years: Underutilization of Pediatric Donors

  2025cites this paper
• Comparison of survival outcomes in preemptive versus non-preemptive kidney transplant recipients

  2025cites this paper
• Estimating the Benefit of Transplant Over Dialysis in Candidates Over 55 Years

  2025cites this paper
• Effect of Hydroxychloroquine Treatment on Kidney Allograft Rejection and Graft Failure.

  2024cites this paper
• The medical cost and outcome of desensitization protocol in kidney transplantation recipients with high immunological risks

  2024cites this paper
• THE ROBOTIC LIVING DONOR KIDNEY DONATION: TECHNICAL ASPECTS AND RESULTS

  2024cites this paper
• BIVARIATE FUNCTIONAL PATTERNS OF LIFETIME MEDICARE COSTS AMONG ESRD PATIENTS.

  2024cites this paper
• Predicting kidney transplant survival using multiple feature representations for HLAs

  2023cites this paper
• Diabetes mellitus and blood glucose variability increases the 30‐day readmission rate after kidney transplantation

  2023cites this paper
• Effect of Cardiac Arrest in Brain-dead Donors on Kidney Graft Function

  2023cites this paper
• Reassessing the survival benefit of deceased donor liver transplantation: retrospective cohort study

  2023cites this paper
• Allokation von Nieren im Zeitalter des Organmangels in Deutschland

  2023cites this paper
• Effect of pulmonary hypertension on 5‐year outcome of kidney transplantation

  2022cites this paper
• Predicting Kidney Transplant Survival using Multiple Feature Representations for HLAs

  2021cites this paper
• Adaptively Weighted Top-N Recommendation for Organ Matching

  2021influential citation
• Choices and Outcomes in Assignment Mechanisms: The Allocation of Deceased Donor Kidneys

  2020cites this paper
• Clinical, immunological and ethical aspects of selecting a recipient for cadaver kidney transplantation

  2020cites this paper
• Клинические, иммунологические и этические аспекты выбора реципиента при трансплантации трупных донорских почек

  2020cites this paper
• A Clinical Study on Cadaveric Kidney Donors in Puerto Rico and the Survival outcome of the grafts: a retrospective study of 187 kidneys from 2009-2011.

  2019cites this paper
• Using machine learning and an ensemble of methods to predict kidney transplant survival

  2019cites this paper
• Allocation of Indivisible Life-Saving Goods With Both Intrinsic and Relational Quality: The New Deceased-Donor Kidney Allocation System

  2019cites this paper
• A mathematical model to describe survival among liver recipients from deceased donors with risk of transmitting infectious encephalitis pathogens

  2019cites this paper
• Impact of Predialysis Psychosocial Conditions on Kidney Transplant Recipient Survival: Evidence Using Propensity Score Matching

  2019cites this paper
• Personalizing the Kidney Transplant Decision: Who Doesn't Benefit From a Kidney Transplant?

  2019cites this paper
• Sarcopenia is associated with longer hospital stay and multiorgan dysfunction in alcoholic hepatitis

  2019cites this paper
• L-ornithine L-aspartate for the Treatment of Sarcopenia in Cirrhosis: Potential Impact on the Outcome of Liver Transplantation

  2019cites this paper
• Is the Updated Kidney Allocation System Working?

  2018cites this paper
• The kidney allocation system does not appropriately stratify risk of pediatric donor kidneys: Implications for pediatric recipients

  2018cites this paper
• An economic assessment of contemporary kidney transplant practice

  2018cites this paper
• Predictive Score for Posttransplantation Outcomes

  2017cites this paper
• FACILITY LOCATION OF ORGAN PROCUREMENT ORGANISATIONS IN INDIAN HEALTH CARE SUPPLY CHAIN MANAGEMENT

  2017cites this paper
• Kidney Transplantation: Have the Promises Been Kept and Needs Met

  2017cites this paper
• A Kidney Graft Survival Calculator that Accounts for Mismatches in Age, Sex, HLA, and Body Size.

  2017cites this paper
• Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise?

  2016cites this paper
• Early Results of Pilot Study Using Hepatitis C Virus (HCV) Positive Kidneys to Transplant HCV Infected Patients with End-Stage Renal Disease Allowing for Successful Interferon-Free Direct Acting Antiviral Therapy after Transplantation

  2016cites this paper
• Predicting patient survival after deceased donor kidney transplantation using flexible parametric modelling

  2016cites this paper
• Poor organ quality and donor–recipient age mismatch rather than poor donation rates account for the decrease in deceased kidney transplantation rates in a Germany Transplant Center

  2015cites this paper
• Clinical issues in renal transplantation in the elderly

  2015cites this paper
• New strategies for evaluating the quality of kidney grafts from elderly donors.

  2015cites this paper
• An examination of contemporary challenges in deceased donor kidney allocation

  2014cites this paper
• Organ Specific Benefits of Transplantation: Outcomes and Economics

  2014cites this paper
• Out‐of‐hospital traumatic cardiac arrest: an underrecognized source of organ donors

  2014cites this paper
• 2 Righting the Shortage An Ethical Reformation of the United States Kidney Transplant System

  2013cites this paper
• The Prognostic Value of Kidney Transplant Center Report Cards

  2013cites this paper
• Comparison of the risk factors effects between two populations: two alternative approaches illustrated by the analysis of first and second kidney transplant recipients

  2013cites this paper
• Fairness, Efficiency, and Flexibility in Organ Allocation for Kidney Transplantation

  2013cites this paper
• Increasing the pool of deceased donor organs for kidney transplantation

  2012cites this paper
• Predicting long-term graft survival in adult kidney transplant recipients.

  2012cites this paper
• Comparative Survival and Economic Benefits of Deceased Donor Kidney Transplantation and Dialysis in People with Varying Ages and Co-Morbidities

  2012cites this paper
• Future challenges in renal transplantation.

  2012cites this paper
• Recipient Age and Time Spent Hospitalized in the Year Before and After Kidney Transplantation

  2012cites this paper
• Frailty and delayed graft function in kidney transplant recipients.

  2012cites this paper
• Fairness in Operations: From Theory to Practice

  2011cites this paper
• The Impact of Donor Type and Quality on Renal Transplant Outcomes

  2011cites this paper
• A review of utility‐based allocation strategies to maximize graft years of deceased donor kidneys

  2011cites this paper
• Improving the allocation system for deceased-donor kidneys.

  2011cites this paper
• Donor-recipient age matching improves years of graft function in deceased-donor kidney transplantation.

  2010cites this paper
• United network for organ sharing (UNOS) organ allocation policy and kidney utilization.

  2010cites this paper
• Fairness , Efficiency and Flexibility in Organ Allocation for Renal Transplantation

  2010cites this paper
• Marked Variation of the Association of ESRD Duration Before and After Wait Listing on Kidney Transplant Outcomes

  2010cites this paper
• The AJT Report: News and issues that affect organ and tissue transplantation

  2010cites this paper
• Sarcopenia and mortality after liver transplantation.

  2010cites this paper
• Enhancing the Expanded Criteria Donor Policy as an Intervention to Improve Kidney Allocation: Is It Actually a ’Net‐Zero’ Model?

  2010cites this paper
• The Elephant in the Room: Failings of Current Clinical Endpoints in Kidney Transplantation

  2010cites this paper
• Ethical models in bioethics: theory and application in organ allocation policies.

  2010cites this paper
• Sarcopenia and Post-Liver Transplant Mortality

  2010cites this paper
• The Right Kidney for the Right Recipient: The Status of Deceased Donor Kidney Allocation Reform

  2010influential citation
• Update on the Development of a New U.S. Kidney Transplant Allocation System

  2009cites this paper