The mitochondrial outer membrane protein import machinery: a new player in apoptosis?

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Frontiers in Bioscience

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2741/3471PMID 19273293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multiple pathways for sorting mitochondrial precursor proteins

  2008cited by this paper
• Bax inserts into the mitochondrial outer membrane by different mechanisms

  2008influential reference
• Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors

  2008cited by this paper
• The BCL-2 protein family: opposing activities that mediate cell death

  2008cited by this paper
• Mitochondrial apoptosis without VDAC

  2007cited by this paper
• The Mitochondrial TOM Complex Is Required for tBid/Bax-induced Cytochrome c Release*

  2007influential reference
• Bax activation and mitochondrial insertion during apoptosis

  2007influential reference
• Conserved roles of Sam50 and metaxins in VDAC biogenesis

  2007influential reference
• Why Do We Still Have a Maternally Inherited Mitochondrial DNA ? Insights from Evolutionary Medicine

  2007influential reference
• How tails guide tail-anchored proteins to their destinations.

  2007cited by this paper
• TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax

  2007cited by this paper
• Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins.

  2007cited by this paper
• Mitochondrial membrane permeabilization in cell death.

  2007cited by this paper
• Control of Bax Homodimerization by Its Carboxyl Terminus*

  2007cited by this paper
• The N Terminus of the Anti-apoptotic BCL-2 Homologue MCL-1 Regulates Its Localization and Function*

  2007cited by this paper
• Translocation of proteins into mitochondria.

  2007cited by this paper
• Mitochondria as the target of the pro-apoptotic protein Bax.

  2006influential reference
• Cytosolic factor‐ and TOM‐independent import of C‐tail‐anchored mitochondrial outer membrane proteins

  2006cited by this paper
• An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway.

  2006influential reference
• Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

  2005cited by this paper
• Mitochondrial Carrier Homolog 2 Is a Target of tBID in Cells Signaled To Die by Tumor Necrosis Factor Alpha

  2005cited by this paper
• Distinct Domains Control the Addressing and the Insertion of Bax into Mitochondria*

  2005influential reference
• Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

  2005cited by this paper
• The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

  2004cited by this paper
• Conformational control of Bax localization and apoptotic activity by Pro168

  2004cited by this paper
• The Pathophysiology of Mitochondrial Cell Death

  2004influential reference
• The Mitochondrial Apoptosis-induced Channel (MAC) Corresponds to a Late Apoptotic Event*

  2004cited by this paper
• Bcl‐xL sequesters its C‐terminal membrane anchor in soluble, cytosolic homodimers

  2004cited by this paper
• Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane

  2003cited by this paper
• ReviewMitochondria : Releasing Power for Life and Unleashing the Machineries of Death

  2003cited by this paper
• VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

  2003cited by this paper
• Yeast as a tool to study Bax/mitochondrial interactions in cell death.

  2003influential reference
• Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis*

  2003cited by this paper
• The N-terminal End of Bax Contains a Mitochondrial-targeting Signal*

  2003cited by this paper
• DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells.

  2003cited by this paper
• Involvement of the N‐terminus of Bax in its intracellular localization and function

  2002cited by this paper
• Bcl-2 and porin follow different pathways of TOM-dependent insertion into the mitochondrial outer membrane.

  2002influential reference
• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  2002cited by this paper
• Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

  2002cited by this paper
• Metaxin is required for tumor necrosis factor‐induced cell death

  2001cited by this paper
• A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

  2001cited by this paper
• Cardiolipin provides specificity for targeting of tBid to mitochondria

  2000cited by this paper
• Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

  1999cited by this paper
• Conformation of the Bax C‐terminus regulates subcellular location and cell death

  1999cited by this paper
• Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20‐glutathione S‐transferase and mitochondrial precursor proteins

  1997influential reference
• Bcl‐2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

  1996cited by this paper
• The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

  1995cited by this paper
• Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

  1993cited by this paper
• Specific binding of mitochondrial protein precursors to liposomes containing cardiolipin.

  1988cited by this paper

• Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies

  2022cites this paper
• Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death

  2022cites this paper
• The Mechanism of Aloe-emodin in the Treatment of Colon Cancer based on Network Pharmacological Analysis

  2020cites this paper
• The Role of Caspase Genes Polymorphisms in Genetic Susceptibility to Philadelphia-Negative Myeloproliferative Neoplasms in a Portuguese Population

  2019cites this paper
• Preparation, structural characterization and bioactivities of Se-containing polysaccharide: A review.

  2018cites this paper
• Genetic susceptibility to myeloproliferative neoplasms and therapeutic efficacy

  2018cites this paper
• The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death.

  2017cites this paper
• Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis.

  2014cites this paper
• Structure and Function of Human DnaJ Homologue Subfamily A Member 1 (DNAJA1) and Its Relationship to Pancreatic Cancer

  2014cites this paper
• The mitochondrial pathways of apoptosis.

  2012influential citation
• Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells.

  2011cites this paper
• Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway.

  2010cites this paper
• Mecanismos de proliferación dependientes del estado redox celular: rol de AKT y otras kinasas involucradas en la progresión del ciclo celular

  2009cites this paper
• Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells.

  2009influential citation