Failure of either corticosteroids or ACTH to increase the leukocyte concentration in milk.

Six cows, free of intramammary infection, were given hourly intravenous injections of cortisol: corticosterone (8:1) for 3 consecutive days at concentrations of 1.0, 3.5, and 9.0 μg./kg. of body weight. After a 2-day recovery period, cows were injected intramuscularly for 3 consecutive days with 250 i.u. of adrenocorticotropic hormone (acth; corticotropin). Only the 9.0-μg. dose of corticosterone and 250 i.u.acth elicited significant (P <0.01) increases in the concentration of circulating leukocytes. Significant increases (P <0.01) in plasma corticosteroid concentrations occurred within 2 minutes after the last hourly injection of all 3 concentrations of corticosteroid was given and seemed to increase with each increase in dose of corticosteroid injected. Neither hourly injections of corticosteroids nor daily injections of acth initiated any change in the concentration of leukocytes in milk.

• Publication year

  1973

• Venue

  American Journal of Veterinary Research

• Publication date

  1973-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2460/ajvr.1973.34.03.353PMID 4348002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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