Biological properties of a specific Gαq/11 inhibitor, YM‐254890, on platelet functions and thrombus formation under high‐shear stress

No abstract is available for this paper.

• Publication year

  2006

• Venue

  British Journal of Pharmacology

• Publication date

  2006-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.bjp.0706711PMID 16520742PMCID PMC1617042
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
• A novel Galphaq/11-selective inhibitor.

  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Antithrombotic and thrombolytic efficacy of YM-254890, a Gq/11 inhibitor, in a rat model of arterial thrombosis

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  2001cited by this paper
• Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.

  2001cited by this paper
• The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets.

  2000cited by this paper
• The central role of the P2T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity

  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses.

  1997cited by this paper
• Platelet signal transduction defect with Gα subunit dysfunction and diminished Gαq in a patient with abnormal platelet responses

  1997cited by this paper
• Defective platelet activation in G alpha(q)-deficient mice.

  1997influential reference
• Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation.

  1996cited by this paper
• Platelet activation via trimeric GTP-binding proteins.

  1996cited by this paper
• Biochemical characterization of a new disintegrin, flavostatin, isolated from Trimeresurus flavoviridis venom.

  1996cited by this paper
• Atherosclerosis and coronary artery diseases

  1996cited by this paper
• Analysis of platelet adhesion to a collagen-coated surface under flow conditions: the involvement of glycoprotein VI in the platelet adhesion.

  1996cited by this paper
• Snake Venom Proteins Modulating the Interaction between von Willebrand Factor and Platelet Glycoprotein lb

  1996cited by this paper
• Inhibition of Thrombus Formation by Endothelin-1 in Canine Models of Arterial Thrombosis

  1995cited by this paper
• Cytoskeletal domains in the activated platelet.

  1995cited by this paper
• ADP causes partial degranulation of platelets in the absence of aggregation

  1994cited by this paper
• New roles for G-protein beta gamma-dimers in transmembrane signalling.

  1993cited by this paper
• Signaling through G Proteins and G Protein-coupled Receptors during Platelet Activation

  1993cited by this paper
• Epinephrine Augments von Willebrand Factor‐Dependent Shear‐Induced Platelet Aggregation

  1992cited by this paper
• Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits.

  1992cited by this paper
• Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

  1992cited by this paper
• The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.

  1991cited by this paper
• Localization of von Willebrand Factor and Thrombin-Interactive Domains on Human Platelet Glycoprotein Ib

  1990cited by this paper
• Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa.

  1987cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper

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  2024cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2008influential citation
• Discovery-based strategies for studying platelet function.

  2008cites this paper
• State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.

  2008cites this paper
• [Pharmacological properties of a specific Gq/11 inhibitor, YM-254890].

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