RAC1 activation drives pathologic interactions between the epidermis and immune cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Clinical Investigation

• Publication date

  2016-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI85738PMID 27294528PMCID PMC4922704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aldara®‐induced skin inflammation: studies of patients with psoriasis

  2015cited by this paper
• Efficacy and Safety of Systemic Long-Term Treatments for Moderate-to-Severe Psoriasis: A Systematic Review and Meta-Analysis.

  2015cited by this paper
• Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis

  2015cited by this paper
• Aldara‐induced skin inflammation in mice: close enough to psoriasis?

  2015cited by this paper
• Immunology of psoriasis.

  2014cited by this paper
• Research gaps in psoriasis: opportunities for future studies.

  2014cited by this paper
• ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes

  2014influential reference
• The DEAH-Box RNA Helicase DHX15 Activates NF-κB and MAPK Signaling Downstream of MAVS During Antiviral Responses

  2014influential reference
• Epithelialization in Wound Healing: A Comprehensive Review

  2014cited by this paper
• Psoriasis prevalence among adults in the United States.

  2014cited by this paper
• Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.

  2014cited by this paper
• Psoriasis and Major Adverse Cardiovascular Events: A Systematic Review and Meta‐Analysis of Observational Studies

  2013cited by this paper
• Efficacy and safety of biologics in erythrodermic psoriasis: a multicentre, retrospective study

  2012cited by this paper
• ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation.

  2012cited by this paper
• Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

  2012cited by this paper
• RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1

  2012cited by this paper
• Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.

  2012influential reference
• The epidermis as an adjuvant.

  2012cited by this paper
• Identification of fifteen new psoriasis susceptibility loci highlights the role of innate immunity

  2012cited by this paper
• Adverse effects of biologics: a network meta-analysis and Cochrane overview.

  2011cited by this paper
• The 'invisible hand': regulation of RHO GTPases by RHOGDIs

  2011cited by this paper
• Genome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasis

  2011cited by this paper
• Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.

  2011cited by this paper
• Psoriasis

  2010cited by this paper
• Regulation of RhoGTPase crosstalk, degradation and activity by RhoGDI1

  2010cited by this paper
• Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

  2010cited by this paper
• Genome-wide association study identifies a psoriasis susceptibility locus at TRAF 3 IP 2

  2010cited by this paper
• Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis1

  2009cited by this paper
• The IL-23/Th17 axis in the immunopathogenesis of psoriasis.

  2009influential reference
• Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis.

  2009cited by this paper
• Psoriasis is associated with increased beta-defensin genomic copy number.

  2008cited by this paper
• Chemokines and other mediators as therapeutic targets in psoriasis vulgaris.

  2008influential reference
• A promoter sequence variant of ZNF750 is linked with familial psoriasis.

  2008cited by this paper
• Psoriasis is associated with increased β-defensin genomic copy number

  2008cited by this paper
• Double Duty for Rac1 in Epidermal Wound Healing

  2007cited by this paper
• IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

  2007influential reference
• Small self-RNA generated by RNase L amplifies antiviral innate immunity

  2007cited by this paper
• Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation1

  2007cited by this paper
• Upregulation of capsule enables Streptococcus pyogenes to evade immune recognition by antigen-specific antibodies directed to the G-related alpha2-macroglobulin-binding protein GRAB located on the bacterial surface.

  2007cited by this paper
• Rac1 Is Crucial for Hair Follicle Integrity but Is Not Essential for Maintenance of the Epidermis

  2006cited by this paper
• In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin

  2006cited by this paper
• Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

  2006cited by this paper
• Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

  2005cited by this paper
• Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

  2005cited by this paper
• Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α

  2004cited by this paper
• Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.

  2003cited by this paper
• α6β4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of α3β1 integrin

  2003cited by this paper
• The Koebner phenomenon: review of the literature

  2002cited by this paper
• Group A Streptococcus tissue invasion by CD44-mediated cell signalling

  2001cited by this paper
• A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis.

  2001cited by this paper
• Rac1 mediates STAT3 activation by autocrine IL-6

  2001cited by this paper
• Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin

  2001cited by this paper
• Regulation of STAT3 by direct binding to the Rac1 GTPase.

  2000cited by this paper
• Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

  2000cited by this paper
• Rac1 Regulates Interleukin 1-induced Nuclear Factor κB Activation in an Inhibitory Protein κBα-independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression*

  2000cited by this paper
• Stimulation of NFκB Activity by Multiple Signaling Pathways Requires PAK1*

  2000cited by this paper
• Detection of C-polysaccharide in serum of patients with Streptococcus pneumoniae bacteraemia.

  1995cited by this paper
• The role of streptococcal infection in the initiation of guttate psoriasis.

  1992cited by this paper
• Localization of elevated transforming growth factor-alpha in psoriatic epidermis.

  1990cited by this paper
• Group A streptococcal peptidoglycan-polysaccharide inhibits phagocytic activity of human polymorphonuclear leukocytes

  1984cited by this paper
• Psoriasis

  1906cited by this paper

• Unrestrained MyD88 signaling in A20-deficient keratinocytes triggers T cell dependent Psoriatic Arthritis like disease.

  2025cites this paper
• Analysis of adverse drug reactions in 507 cases of Tislelizumab: A real-world retrospective study based on data from Guangxi, China

  2025cites this paper
• New Insights into the Pathogenesis of Psoriatic Arthritis.

  2025cites this paper
• What are mice teaching us about psoriatic arthritis?

  2025cites this paper
• Discovery of a novel ROS-based signature for predicting prognosis and immunosuppressive tumor microenvironment in lung adenocarcinoma

  2024cites this paper
• Repurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation.

  2024cites this paper
• Calcitriol modulates epidermal tight junction barrier function in human keratinocytes.

  2024cites this paper
• Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course

  2023cites this paper
• Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death

  2023cites this paper
• The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

  2023cites this paper
• Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS

  2023cites this paper
• Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction.

  2023cites this paper
• Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy

  2022cites this paper
• The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

  2022cites this paper
• Advances in the pathogenesis of psoriasis: from keratinocyte perspective

  2022cites this paper
• Rac1, A Potential Target for Tumor Therapy

  2021cites this paper
• Mouse Models of Psoriasis: A Comprehensive Review.

  2021cites this paper
• Transcriptional Analysis-Based Alterations Affecting Neuritogenesis of the Peripheral Nervous System in Psoriasis

  2021cites this paper
• Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression

  2021cites this paper
• Dysregulation of lncRNAs in autoimmune neuropathies

  2021cites this paper
• A computational multi-targeting approach for drug repositioning for psoriasis treatment

  2021cites this paper
• Integrated analysis of miRNA‐mRNA networks reveals a strong anti‐skin cancer signature in vitiligo epidermis

  2021cites this paper
• Animal models of psoriasis-highlights and drawbacks.

  2020cites this paper
• Keratinocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Genetic Signature of Psoriasis Disease

  2020cites this paper
• KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.

  2020cites this paper
• Characterization of PCSK9 in the Blood and Skin of Psoriasis.

  2020cites this paper
• Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis

  2020cites this paper
• Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis

  2020cites this paper
• Activation of STAT transcription factors by the Rho-family GTPases

  2020cites this paper
• Synergistic induction of IL-23 by TNFα, IL-17A, and EGF in keratinocytes.

  2020cites this paper
• Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis

  2020cites this paper
• Loss of the Epigenetic Mark, 5-hmC, in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.

  2019cites this paper
• Epidermal activation of the small GTPase Rac1 in psoriasis pathogenesis

  2019cites this paper
• From cell shape to cell fate via the cytoskeleton - Insights from the epidermis.

  2019cites this paper
• IL-17 and IL-22 Promote Keratinocyte Stemness in the Germinative Compartment in Psoriasis.

  2019cites this paper
• A toxic palmitoylation on Cdc42 drives a severe autoinflammatory syndrome

  2019cites this paper
• DLC-3 suppresses cellular proliferation, migration, and invasion in triple-negative breast cancer by the Wnt/β-catenin pathway.

  2019cites this paper
• Psoriasis: Past, Present, and Future.

  2019cites this paper
• An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis

  2019cites this paper
• Seborrheic dermatitis—Looking beyond Malassezia

  2019cites this paper
• Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease

  2019cites this paper
• Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway

  2018cites this paper
• Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia.

  2018cites this paper
• Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis.

  2018influential citation
• Defining the importance of protein geranylgeranylation in innate immunity

  2018cites this paper
• Topical Application of Tat-Rac1 Promotes Cutaneous Wound Healing in Normal and Diabetic Mice

  2018cites this paper
• Identification of differentially expressed miRNAs through high-throughput sequencing in the chicken lung in response to Mycoplasma gallisepticum HS.

  2017cites this paper
• ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.

  2017influential citation
• LMO4 Is a Disease-Provocative Transcription Coregulator Activated by IL-23 in Psoriatic Keratinocytes.

  2017cites this paper
• RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin

  2017cites this paper
• miR-4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin/integrin α9 signaling.

  2017cites this paper
• Rac1 signaling regulates cigarette smoke-induced inflammation in the lung via the Erk1/2 MAPK and STAT3 pathways.

  2017cites this paper
• CD100-Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-κB and the Inflammasome in Keratinocytes.

  2017cites this paper
• IAPs protect host target tissues from graft-versus-host disease in mice.

  2017cites this paper
• An update on psoriasis and metabolic syndrome: A meta-analysis of observational studies

  2017cites this paper
• A cc ep te d A rti cl e Proinflammatory effect of HMGB 1 on keratinocytes : an autocrine mechanism underlying psoriasis development Running title : Role of HMGB 1 in Psoriasis Development

  2016cites this paper
• Proinflammatory effect of high‐mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development

  2016cites this paper