Effect of curcumin on the inflammatory reaction and functional recovery after spinal cord injury in a hyperglycemic rat model.

BACKGROUND CONTEXT Curcumin has anti-inflammatory and antioxidant activities. OBJECTIVE This study aimed to investigate the effects of curcumin on the histological changes and functional recovery following spinal cord injury (SCI). STUDY DESIGN One hundred twenty-eight Sprague-Dawley rats were distributed into a sham, SCI only, SCI-hyperglycemia, and SCI-hyperglycemia-curcumin (200 mg/kg/day, i.p.) groups. METHODS SCI was induced using a clip at T9-10 and hyperglycemia was induced by streptozotocin (60-70 mg/kg, i.v.). Plasma malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity was measured to determine oxidative stress. The activity of macrophages in the spinal cord after SCI was stained by the anti-CD68 antibody (ED-1). The tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-8 levels were measured by enzyme-linked immunosorbent assay and Western blot was used to verify the levels of mitogen-activated protein kinases and STAT3. The glial fibrillary acidic protein (GFAP) expression was evaluated by immunofluorescence analysis. Functional recovery was assessed according to the Basso, Beattie, and Bresnahan (BBB) scale and histologic outcome was evaluated by the lesion volume and spared tissue area. RESULTS SOD activity increased, the MDA level decreased, and ED-1 macrophage marker level decreased in the SCI-hyperglycemia-curcumin group than in the SCI-hyperglycemia group at 2 weeks after SCI (p < 0.01). The SCI-hyperglycemia-curcumin group showed a statistically significant reduction in IL-6, IL-8, and TNF-α levels compared to the SCI-hyperglycemia group after SCI. The phosphorylated-extracellular signal-regulated kinase, phosphorylated-JNK, and phospho-p38 levels were significantly lower in the SCI-hypoglycemia-curcumin group than in the SCI-hypoglycemia group. The SCI-hyperglycemia-curcumin group showed a decrease in GFAP expression after SCI compared to the SCI-hyperglycemia group. The SCI-hyperglycemia-curcumin group showed a lower lesion volume, higher spared tissue, and better functional recovery than the SCI-hyperglycemia group. CONCLUSION Curcumin may have a potential neuroprotective effect in SCI with hyperglycemia. CLINICAL SIGNIFICANCE Curcumin decreased the inflammatory response and decreased astrogliosis and improved the functional recovery and histologic outcomes in SCI with hyperglycemia.

• Publication year

  2019

• Venue

  The spine journal

• Publication date

  2019-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.spinee.2019.07.013PMID 31421247
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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