Neuroinflammation als Motor der Alzheimer-Erkrankung

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Der Nervenarzt

• Publication date

  2019-08-19

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1007/s00115-019-0778-3PMID 31428829
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ApoE attenuates unresolvable inflammation by complex formation with activated C1q

  2019cited by this paper
• Microglia in Alzheimer's disease: A target for immunotherapy

  2019cited by this paper
• Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

  2019cited by this paper
• Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

  2019cited by this paper
• Traumatic Brain Injury as a Risk Factor for Dementia and Alzheimer Disease: Critical Review of Study Methodologies

  2019cited by this paper
• Single-cell transcriptomic analysis of Alzheimer’s disease

  2019cited by this paper
• Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition.

  2019cited by this paper
• Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

  2018cited by this paper
• Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

  2018cited by this paper
• TREM2 — a key player in microglial biology and Alzheimer disease

  2018cited by this paper
• Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

  2017cited by this paper
• TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.

  2017cited by this paper
• The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

  2017cited by this paper
• Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

  2017cited by this paper
• Neonatal microglia: The cornerstone of brain fate.

  2017cited by this paper
• Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

  2017cited by this paper
• Danger‐associated molecular patterns in Alzheimer’s disease

  2017cited by this paper
• A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

  2017cited by this paper
• TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

  2017cited by this paper
• Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

  2017cited by this paper
• Neurotoxic reactive astrocytes are induced by activated microglia

  2017cited by this paper
• A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.

  2017cited by this paper
• Complement and microglia mediate early synapse loss in Alzheimer mouse models

  2016cited by this paper
• Distinct inflammatory phenotypes of microglia and monocyte‐derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology

  2016cited by this paper
• Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

  2016cited by this paper
• sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

  2016cited by this paper
• Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.

  2016cited by this paper
• Dark microglia: A new phenotype predominantly associated with pathological states

  2016cited by this paper
• The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

  2016cited by this paper
• Neuroinflammation in Alzheimer's disease.

  2015cited by this paper
• Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer's disease.

  2015cited by this paper
• Anti-Inflammatory Drugs and Risk of Alzheimer's Disease: An Updated Systematic Review and Meta-Analysis

  2015cited by this paper
• Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.

  2015cited by this paper
• Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease.

  2015cited by this paper
• Depletion of microglia and inhibition of exosome synthesis halt tau propagation

  2015cited by this paper
• IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

  2015cited by this paper
• Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

  2014cited by this paper
• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

  2014cited by this paper
• Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

  2014cited by this paper
• Analysis of COQ2 gene in multiple system atrophy

  2014cited by this paper
• Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

  2013cited by this paper
• CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation

  2013cited by this paper
• In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.

  2013cited by this paper
• Sensory receptors—design principles revisited

  2013cited by this paper
• Sustained Interleukin-1β Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

  2013cited by this paper
• Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

  2013cited by this paper
• Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

  2013cited by this paper
• Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

  2013cited by this paper
• Neurotransmitter signaling in the pathophysiology of microglia

  2013cited by this paper
• Variant of TREM2 associated with the risk of Alzheimer's disease.

  2013cited by this paper
• Microglia

  2013cited by this paper
• TREM2 variants in Alzheimer's disease.

  2013cited by this paper
• Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer’s disease in Han Chinese

  2013cited by this paper
• Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

  2012cited by this paper
• Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

  2012cited by this paper
• Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.

  2011cited by this paper
• TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

  2011cited by this paper
• Deletion of CD14 Attenuates Alzheimer's Disease Pathology by Influencing the Brain's Inflammatory Milieu

  2010cited by this paper
• IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice

  2010cited by this paper
• Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

  2010cited by this paper
• Regulation of tau pathology by the microglial fractalkine receptor.

  2010cited by this paper
• Massive gliosis induced by interleukin‐6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

  2010cited by this paper
• Alzheimer's disease.

  2010cited by this paper
• Long-term cognitive impairment and functional disability among survivors of severe sepsis.

  2010cited by this paper
• Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

  2009cited by this paper
• Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease

  2009cited by this paper
• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes

  2009cited by this paper
• A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

  2009cited by this paper
• Physical activity, diet, and risk of Alzheimer disease.

  2009cited by this paper
• Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice.

  2009cited by this paper
• Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

  2009cited by this paper
• The NALP3 inflammasome is involved in the innate immune response to amyloid-β

  2008cited by this paper
• Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease.

  2008cited by this paper
• Origin and physiological roles of inflammation

  2008cited by this paper
• Apolipoprotein E

  2007cited by this paper
• Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.

  2006cited by this paper
• Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease.

  2004cited by this paper
• A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation

  2003cited by this paper
• Interleukin‐1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer’s disease

  2002cited by this paper
• Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils.

  1996cited by this paper
• RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

  1996cited by this paper
• Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

  1996cited by this paper
• RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.

  1996cited by this paper
• An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde".

  1995cited by this paper
• An english translation of alzheimer's 1907 paper, “über eine eigenartige erkankung der hirnrinde”

  1995cited by this paper
• Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

  1988cited by this paper

• Innate Immune Tolerance Regulates Microglia Response to Aβ Oligomers

  2026cites this paper
• Innate immune activation in neurodegenerative diseases.

  2024cites this paper
• Therapeutic Targets in Innate Immunity to Tackle Alzheimer’s Disease

  2024cites this paper
• Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells

  2023cites this paper
• Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease

  2021cites this paper
• Probiotic Bifidobacterium breve Prevents Memory Impairment Through the Reduction of Both Amyloid-β Production and Microglia Activation in APP Knock-In Mouse

  2021cites this paper
• Krankheitsmodifizierende Therapieansätze bei Alzheimer-Krankheit

  2021cites this paper
• Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

  2021cites this paper