Construction of C(sp2)-C(sp3) Bond between Quinoxalin-2(1H)-ones and N-Hydroxyphthalimide Esters via Photocatalytic Decarboxylative Coupling.

A novel visible-light-driven decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP esters) with quinoxalin-2(1H)-ones has been developed. This C(sp2)-C(sp3) bond-forming transformation exhibits excellent substrate generality with respect to both the coupling partners, and of note, a series of 3-primary alkyl substituted quinoxalin-2(1H)-ones that were difficult to synthesize by previous methods could be obtained in moderate to excellent yields. Additionally, the mild conditions, easy availability of substrates, wide functional group tolerance and operational simplicity make this protocol practically in synthesis of 3-alkylated quinoxalin-2(1H)-ones.

• Publication year

  2019

• Venue

  Chemistry - An Asian Journal

• Publication date

  2019-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/asia.201900904PMID 31432590
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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