Dietary restriction in the epigenomic regulation of cardiovascular diseases

Abstract Most cardiovascular diseases (CVDs) are age-related diseases. The prevalence of cardiovascular risk factors increases with age and cardiovascular aging contributes to the development of CVDs. Mounting evidence has demonstrated that dietary restriction (DR), a nutritional anti-aging intervention, confers cardiovascular protection and may decrease morbidity and mortality of CVDs. The mechanisms underlying the beneficial cardiovascular effects of DR are multifaceted, but recent investigations reveal that DR triggers an active defense response against stress. At the center of this response are cardiovascular protective signals, which include the mammalian target of rapamycin, AMP-activated kinase, endothelial nitric oxide synthase, and NAD+-dependent deacetylases called sirtuins. Among them, sirtuins play two important roles: epigenomic regulation and post-translational modification. However, epigenomic regulation of the cardiovascular system by DR has not been fully clarified. In this chapter, we discuss the molecular mechanisms by which DR confers cardiovascular protection and the possible involvement of sirtuins in epigenomic regulation.

• Publication year

  2019

• Venue

  Nutritional Epigenomics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/B978-0-12-816843-1.00017-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Spermidine in health and disease

  2018cited by this paper
• Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure

  2018cited by this paper
• SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart

  2018cited by this paper
• Caloric restriction delays age-related methylation drift

  2017cited by this paper
• MicroRNAs and the Metabolic Hallmarks of Aging

  2017cited by this paper
• Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet.

  2017cited by this paper
• NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging

  2017cited by this paper
• Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice

  2016cited by this paper
• Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion.

  2016cited by this paper
• Resveratrol and Cardiovascular Diseases

  2016cited by this paper
• Cardioprotection and lifespan extension by the natural polyamine spermidine

  2016cited by this paper
• Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions

  2015cited by this paper
• Indispensable role of endothelial nitric oxide synthase in caloric restriction-induced cardioprotection against ischemia-reperfusion injury.

  2015cited by this paper
• Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors--Results from a systematic review and meta-analysis of randomized controlled trials.

  2015cited by this paper
• Cardioprotective Signature of Short-Term Caloric Restriction

  2015cited by this paper
• Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials.

  2015cited by this paper
• Inhibition of AMPK accentuates prolonged caloric restriction-induced change in cardiac contractile function through disruption of compensatory autophagy.

  2015cited by this paper
• Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis.

  2015cited by this paper
• Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

  2014cited by this paper
• Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

  2014cited by this paper
• Effects of Calorie Restriction and Diet-Induced Obesity on Murine Colon Carcinogenesis, Growth and Inflammatory Factors, and MicroRNA Expression

  2014cited by this paper
• Cardiovascular and Cerebrovascular Aging—New Mechanisms and Insights: Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

  2014cited by this paper
• Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

  2014cited by this paper
• Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

  2013cited by this paper
• Circulating factors induced by caloric restriction in the non‐human primate Macaca mulatta activate angiogenic processes in endothelial cells

  2013cited by this paper
• Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

  2013cited by this paper
• AMP Activated Protein Kinase Is Indispensable for Myocardial Adaptation to Caloric Restriction in Mice

  2013cited by this paper
• Caloric Restriction: IMPLICATIONS FOR HUMAN CARDIOMETABOLIC HEALTH

  2013cited by this paper
• Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins

  2013cited by this paper
• Age-associated miRNA Alterations in Skeletal Muscle from Rhesus Monkeys reversed by caloric restriction

  2013cited by this paper
• Life‐long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

  2013cited by this paper
• The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

  2012cited by this paper
• Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance.

  2012cited by this paper
• The sirtuin SIRT6 regulates lifespan in male mice

  2012cited by this paper
• Sirtuins as regulators of metabolism and healthspan

  2012cited by this paper
• Food Polyamine and Cardiovascular Disease -An Epidemiological Study-

  2012cited by this paper
• The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

  2012cited by this paper
• The intersection between aging and cardiovascular disease.

  2012cited by this paper
• The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

  2012cited by this paper
• Isoform-selective HDAC inhibitors: closing in on translational medicine for the heart.

  2011cited by this paper
• Caloric Restriction Primes Mitochondria for Ischemic Stress by Deacetylating Specific Mitochondrial Proteins of the Electron Transport Chain

  2011cited by this paper
• Is Autophagy in Response to Ischemia and Reperfusion Protective or Detrimental for the Heart?

  2011cited by this paper
• Protection of the heart against ischemia/reperfusion by silent information regulator 1.

  2011cited by this paper
• Caloric restriction.

  2011cited by this paper
• Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1.

  2011cited by this paper
• Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

  2011cited by this paper
• Epigenetic Control of Aging

  2011cited by this paper
• Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

  2011cited by this paper
• Effects of calorie restriction on cardioprotection and cardiovascular health.

  2011cited by this paper
• Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging.

  2011cited by this paper
• Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

  2010cited by this paper
• Inhibition of autophagy in the heart induces age-related cardiomyopathy

  2010cited by this paper
• Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta.

  2010cited by this paper
• How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis).

  2010cited by this paper
• The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

  2010cited by this paper
• Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.

  2009cited by this paper
• Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice

  2009cited by this paper
• Long-term oral polyamine intake increases blood polyamine concentrations.

  2009cited by this paper
• Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

  2009cited by this paper
• Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1.

  2008cited by this paper
• Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

  2008cited by this paper
• Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

  2008cited by this paper
• Telomere Biology and Cardiovascular Disease Vascular Cell Senescence: Contribution to Atherosclerosis Stem Cells and the Regeneration of the Aging Cardiovascular System Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Mechanisms Underlying Caloric Restriction and Lifespan Regulati

  2008cited by this paper
• Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

  2008cited by this paper
• Caloric restriction in humans.

  2007cited by this paper
• SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

  2007cited by this paper
• Direct Evidence of Endothelial Oxidative Stress With Aging in Humans: Relation to Impaired Endothelium-Dependent Dilation and Upregulation of Nuclear Factor-&kgr;B

  2007cited by this paper
• Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

  2007cited by this paper
• Cardioprotective Effects of Short-Term Caloric Restriction Are Mediated by Adiponectin via Activation of AMP-Activated Protein Kinase

  2007cited by this paper
• Long-term caloric restriction ameliorates the decline in diastolic function in humans.

  2006cited by this paper
• Suppression of Class I and II Histone Deacetylases Blunts Pressure-Overload Cardiac Hypertrophy

  2006cited by this paper
• Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction.

  2006cited by this paper
• Moderate calorie restriction improves cardiac remodeling and diastolic dysfunction in the Dahl-SS rat.

  2006cited by this paper
• Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

  2005cited by this paper
• Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

  2005cited by this paper
• Overview of caloric restriction and ageing.

  2005cited by this paper
• Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems.

  2005cited by this paper
• Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts.

  2005cited by this paper
• Silent Information Regulator 2&agr;, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes

  2004cited by this paper
• Sir2 mediates longevity in the fly through a pathway related to calorie restriction.

  2004cited by this paper
• Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

  2004cited by this paper
• Antioxidant supplements for preventing gastrointestinal cancers.

  2004cited by this paper
• Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload

  2004cited by this paper
• Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.

  2004cited by this paper
• Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease.

  2003cited by this paper
• Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease.

  2003cited by this paper
• Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials

  2003cited by this paper
• Pathophysiology of ageing.

  2002cited by this paper
• Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.

  2002cited by this paper
• Mitochondrial Decay in the Aging Rat Heart

  2002cited by this paper
• Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

  2001cited by this paper
• Effects of chronic food restriction and exercise training on the recovery of cardiac function following ischemia.

  2001cited by this paper
• Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury.

  2001cited by this paper
• Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

  2000cited by this paper
• The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

  1999cited by this paper
• The age-associated alterations in late diastolic function in mice are improved by caloric restriction.

  1997cited by this paper
• Comparison of the age- and tumor-associated changes in the c-myc gene methylation in mouse liver.

  1993cited by this paper
• Effects of caloric restriction in animals on cellular function, oncogene expression, and DNA methylation in vitro.

  1993cited by this paper
• The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

  1935cited by this paper
• Chromatin Modifications and Their Function

  year unknowncited by this paper

• No citing papers are available for this paper.