A Novel Biodegradable Hollow Nanocarrier Consisting Superparamagnetic Fe3O4-loaded poly-γ- glutamic Acid and Chitosan Oligosaccharide for Targeted Delivery of Sulforaphane from Broccoli Seed Extracts

The aim of this study was to synthesize a polymeric nanocarrier system loaded with superparamagnetic iron oxide nanoparticles (SPION) and the sulforaphane(SFN) through a cross-linking method in order to protect the SFN. According to this experiment, the drug-loading content and encapsulation efficiency were 29.97±0.08% and 0.34±0.41%, respectively. The total cumulative amount of SFN, released from the nanocarrier in vitro was 87.90% over a 72 h period. MTT assays indicated that the SPION-SFN-loaded nanocarrier exhibited a much higher in vitro antitumor efficacy than free SFN. Together, these results indicate that SPION-loaded nanocarrier exhibits good drug-loading ability and sustained-release function.

• Publication year

  2019

• Venue

  Journal of Hard Tissue Biology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.2485/JHTB.28.297
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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