LIM kinase 1 deficient mice have reduced bone mass.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Bone

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bone.2012.09.024PMID 23017662PMCID PMC3688839
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• University of Birmingham

  1951cited by this paper

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