Investigation of Mutations of ERG11 Gene in Fluconazole Resistant Strains of Candida Albicans Isolated From Patients With Volvovaginitis in West of Mazandaran

DOI: 10.30699/ijmm.13.1.14 Background and Aims: Candida albicans as an opportunistic fungal pathogen in human is the cause of volvovaginitis candidiasis. Azole resistance is cinsiderable as worldwide problem in treatment of candidiasis. Azole resistance can occur through different mechanisms such as mutation in ERG11 gene. The aim of our study was evaluation of ERG11 gene mutations in fluconazole resistant islotes of C. albicans obtained from patients with volvovaginitis in west of Mazandaran.

• Publication year

  2019

• Venue

  Iranian Journal of Medical Microbiology

• Publication date

  2019-05-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.30699/IJMM.13.1.14
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• ERG11 gene mutations were evaluated in fluconazole-resistant Candida albicans isolates collected from patients with vulvovaginitis in west of Mazandaran.

  Confidence 0.88

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review

• candida albicans

  fungal species

  The opportunistic fungal species investigated as the source of the clinical isolates.

  Aliases: C. albicans

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• erg11 gene

  gene

  A Candida albicans gene examined here for sequence mutations associated with azole resistance.

  Aliases: ERG11

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• fluconazole-resistant isolates

  microbial isolate, resistance phenotype

  Candida albicans isolates that are not susceptible to fluconazole and were selected for mutation assessment.

  Aliases: fluconazole resistant strains, fluconazole resistant isolates

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• vulvovaginitis

  condition

  The vaginal inflammatory/infectious condition present in the patients from whom isolates were obtained.

  Aliases: volvovaginitis candidiasis, vulvovaginal candidiasis

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review

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