SCIENCE@home

Codon codes: Codon usage bias influences many levels of gene expression

Yunkun Dang,Yingying Dong,Guiping Ren

Published 2019 in Scientia Sinica Vitae

ABSTRACT

Synonymous mutations, which do not change the primary sequences of encoded proteins, are often recognized as silent mutations. In particular, the selection of synonymous codons at an evolutionary scale is constrained and has resulted in uneven occurrences, a phenomenon called codon usage bias. In recent decades, the roles of codon usage bias in fine-tuning transcription, post-transcriptional processing, mRNA stability, translation initiation, elongation, and peptide folding have been revealed. Upon disrupting these biological processes, synonymous mutations have been reported to cause various diseases such as cancer. Herein, we briefly review the current understanding concerning the molecular mechanisms of transcription and translation processes regulated by codon usage bias as well as the implications for basic and translational research inmedicine.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-67 of 67 references · Page 1 of 1

CITED BY

Showing 1-5 of 5 citing papers · Page 1 of 1