Simultaneous determination of cinobufagin and its five metabolites in rat plasma by LC-MS/MS for characterization of metabolic profiles and pharmacokinetic study

Wen-long Wei,Haojv Li,Zhenwei Li,Hua Qu,Juan Da,Xu Jin,Ying-ying Wang,Wan-ying Wu,D. Guo

Published 2019 in Analytical Methods

ABSTRACT

Cinobufagin, an ingredient ofVenenum Bufonishas various pharmacological activities and toxicities. In this study we simultaneously determine cinobufagin (quantification) and its five main metabolites (semi-quantification) in rat plasma.

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