Synthesis and application of axially chiral biscarbolines with functional N-O and sulfone for 1,2-transfer hydrogenations of ketimines

Abstract A series of axially chiral biscarboline-based sulfones were synthesized from l -tryptophane and applied for enantioselective 1,2-transfer hydrogenations of ketimines using trichlorosilane. The catalyst 4e, which had a tertiary butyl group, exhibited a good conversion and high enantioselectivities up to 96%ee in the series of reactions.

• Publication year

  2019

• Venue

  Tetrahedron

• Publication date

  2019-08-01

• Fields of study

  Chemistry

• Identifiers
  DOI 10.1016/j.tet.2019.130495
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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