The discoverers of the reaction

D. Lewis

Published 2019 in The Wolff-Kishner Reduction and Related Reactions

ABSTRACT

Abstract In 1911, Russian chemist Nikolai Matveevich Kizhner (1867–1935) at Tomsk Technological Institute, in Siberia, discovered the decomposition of the hydrazones of aldehydes and ketones by solid potassium hydroxide at elevated temperatures to give the corresponding methylene compounds. In 1912, Ludwig Wolff, at Friedrich-Schiller-Universitat in Jena described the same overall transformation starting from the semicarbazone of the carbonyl compound. In this chapter, the lives of both chemists, and their other contributions to the development of organic chemistry (the Kizhner cyclopropane synthesis, the Wolff rearrangement) are summarized.

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